SB-649,915

Izvor: Wikipedia
SB-649,915
(IUPAC) ime
6-[(1-[3-(2-metalhinolin-5-il)oksipropil]piperidin-4-il)metil]-4H-1,4-benzoksazin-3-on
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 10225553
ChEMBL[3] CHEMBL183460
Hemijski podaci
Formula C26H29N3O3 
Mol. masa 431,526 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Nije kontrolisan

SB-649,915 je inhibitor preuzimanja serotonina i antagonist 5-HT1A i 5-HT1B receptora koji se istražuje zbog njegovog antidepresivnog dejstva.[4] U odnosu na selectivne inhibitore preuzimanja serotonina (SSRI), SB-649,915 ima brži početak dejstva i verovatno ima veću kliničku efikasnost.[4][4]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  4. 4.0 4.1 4.2 Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. (2007). "SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.". Neuropsychopharmacology. 32 (10): 2163–2172. doi:10.1038/sj.npp.1301341. PMID 17356576. 

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