Piklozotan

Izvor: Wikipedia
Piklozotan
(IUPAC) ime
3-hloro-4-[4-[4-(2-piridinil)-1,2,3,6-tetrahidropiridin-1-il]butil]-1,4-benzoksazepin-5(4H)-on
Klinički podaci
Identifikatori
CAS broj 182415-09-4
ATC kod nije dodeljen
PubChem[1][2] 9801640
UNII FQE44HS7AH YesY
Hemijski podaci
Formula C23H24ClN3O2 
Mol. masa 409,909 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Nije kontrolisana supstanca

Piklozotan (SUN-N4057) je selektivni parcijalni agonist 5-HT1A receptora, koji ima neuroprotektivno dejstvo u životinjskim studijama.[3] On je bio u ranim kliničkim ispitivanjima za tretman akutnog moždanog udara.[4][5]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Kamei, K.; Maeda, N.; Nomura, K.; Shibata, M.; Katsuragi-Ogino, R.; Koyama, M.; Nakajima, M.; Inoue, T. et al. (2006). "Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan.". Bioorganic & Medicinal Chemistry 14 (6): 1978–1992. doi:10.1016/j.bmc.2005.10.046. PMID 16290165. 
  4. Ferro, J.; Dávalos, A. (2006). "Other neuroprotective therapies on trial in acute stroke". Cerebrovascular diseases (Basel, Switzerland). 21 Suppl 2 (2): 127–130. doi:10.1159/000091712. PMID 16651823. 
  5. Mondick, J.; Oo, C.; Patel, D.; Fujitani, T.; Shimizu, K.; Barrett, J. (2009). "Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan". American journal of therapeutics 16 (2): 106–115. doi:10.1097/MJT.0b013e31816b8c85. PMID 19300037. }

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