Oksaflozan

Izvor: Wikipedia
Oksaflozan
(IUPAC) ime
4-propan-2-il-2-[3-(trifluorometil)fenil]morfolin
Klinički podaci
Identifikatori
CAS broj 26629-86-7
ATC kod N06AX10
PubChem[1][2] 432824
ChemSpider[3] 382782
UNII V4WLW77V5Q YesY
KEGG[4] D07340
Hemijski podaci
Formula C14H18F3NO 
Mol. masa 273,29 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Prescription only
Način primene Oralno

Oksaflozan (Confliktan) je antidepresiv i anksiolitik koji je uveden u prodaju 1982. za tretmant depresije, ali je u međuvremenu izašao iz upotrebe.[5][6] On je prolek za N-dealkiloksaflozan, koji deluje kao neselektivni agonist serotoninskih receptora: 5-HT1A (pKi = 7,1), 5-HT2A (pKi = 6,0), i 5-HT2C (pKi = 7,5).[7] Oksaflozan potencijalno ima i antiholinergičko dejstvo pri visokim dozama.[8]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. str. 766. ISBN 3-88763-075-0. http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA766&dq=oxaflozane%20conflictan&as_brr=3&pg=PA766#v=onepage&q=&f=false. 
  6. Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. str. 1122. ISBN 0-8155-1144-2. http://books.google.com/books?id=XCsJgUnclbcC&lpg=PA1122&dq=oxaflozane%20conflictan&as_brr=3&pg=PA1122#v=onepage&q=&f=false. 
  7. Leysen DC (February 1999). "Selective 5-HT2C agonists as potential antidepressants". IDrugs : the Investigational Drugs Journal 2 (2): 109–20. PMID 16160946. 
  8. Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). "Oxaflozane overdose in a child". Journal of Toxicology. Clinical Toxicology 30 (1): 123–6. PMID 1542141. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]