Zalospiron

Zalospiron
(IUPAC) ime
	(3aα,4α,4aβ,6aβ,7α,7aα)-heksahidro-2-(4-(4-(2-pirimidinil)-1-piperazinil)butil)-4,7-eteno-1H-ciklobut(f)izoindol-1,3(2H)-dion
Klinički podaci
Identifikatori
CAS broj	114298-18-9
ATC kod	nije dodeljen
PubChem	163925
UNII	0449O95Z1J
Hemijski podaci
Formula	C24H29N5O2
Mol. masa	419,519 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C24H29N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3-9,16-21H,1-2,10-15H2/t16-,17+,18-,19+,20-,21+ ; Key: AERLHOTUXIJQFV-RCPZPFRWSA-N
Farmakokinetički podaci
Poluvreme eliminacije	1-4 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisana supstanca
Način primene	Oralno

Zalospiron (WY-47,846) je selektivan parcijalni agonist 5-HT_1A receptora iz azapironskhe hemijske klase.^[3]^[4] Utvrđeno je da je efektivan u tretmanu anksioznosti i depresije u kliničkim ispitivanjima, ali da je visok udeo pacijenata napustio ispitivanje zbog nuspojava, te je razvoj prekinut.^[5]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gleeson, S; Barrett, JE (1990). „5-HT1A agonist effects on punished responding of squirrel monkeys”. Pharmacology, Biochemistry, and Behavior 37 (2): 335-7. DOI:10.1016/0091-3057(90)90344-H. PMID 1981937.
↑ Singh, A; Lucki, I (1993). „Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors”. Neuropharmacology 32 (4): 331-40. DOI:10.1016/0028-3908(93)90153-T. PMID 8497336.
↑ Rickels, K; Derivan, A; Kunz, N; Pallay, A; Schweizer, E (1996). „Zalospirone in major depression: a placebo-controlled multicenter study”. Journal of Clinical Psychopharmacology 16 (3): 212-7. DOI:10.1097/00004714-199606000-00004. PMID 8784652.

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