8-OH-DPAT

Izvor: Wikipedia
8-OH-DPAT
Kekulé, skeletal formula of 8-OH-DPAT
IUPAC ime
Naziv po klasifikaciji 7-(Dipropilamino)-5,6,7,8-tetrahidronaftalen-1-ol[1]
Identifikacija
Abrevijacija 8-OH-DPAT
CAS registarski broj 78950-78-4 YesY
PubChem[2][3] 1220
6603866 (R)
10125797 (S)
ChemSpider[4] 1183 YesY, 5036174 (R) YesY, 8301316 (S) YesY
MeSH 8-Hydroxy-2-(di-N-propylamino)tetralin
ChEMBL[5] CHEMBL56 YesY
IUPHAR ligand 7
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C16H25NO
Molarna masa 247.38 g mol−1
log P 3,711
pKa 10,539
Baznost (pKb) 3,458
Farmakologija
Vreme polu-uklanjanja iz organizma 1,5 sata

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

8-OH-DPAT je istraživačka hemikalija iz aminotetralinske hemijske klase koja je razvijena tokom 1980-tih i široko korišćena u ispitivanju funkcije 5-HT1A receptora. On je bio jedan od prvih agonista) 5-HT1A receptora.

Originalno se verovalo da je selektivan za 5-HT1A receptor. Kasnije je utvrđeno da 8-OH-DPAT takođe deluje kao agonist 5-HT7 receptora i kao inhibitor serotoninskog preuzimanja/agens serotoninskog otpuštanja.[6][7][8][9][10]

Reference[uredi - уреди]

  1. "8-hydroxy-2-(di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1220. 
  2. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  3. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  4. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Larsson LG, Rényi L, Ross SB, Svensson B, Angeby-Möller K (February 1990). "Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT". Neuropharmacology 29 (2): 85–91. doi:10.1016/0028-3908(90)90047-U. PMID 1691832. 
  7. Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (January 2004). "8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production". Neuropharmacology 46 (1): 52–62. doi:10.1016/j.neuropharm.2003.08.007. PMID 14654097. 
  8. "IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7". http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2337. 
  9. Assié MB, Koek W (November 1996). "Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats". British Journal of Pharmacology 119 (5): 845–50. PMC 1915946. PMID 8922730. 
  10. Wölfel R, Graefe KH (February 1992). "Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter". Naunyn-Schmiedeberg's Archives of Pharmacology 345 (2): 129–36. doi:10.1007/BF00165727. PMID 1570019. 

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