Alnespiron

Alnespiron
(IUPAC) ime
	(+)-4-dihidro-2H-hromen-3-il]-propilamino]butil]-8-azaspiro[4.5]dekan-7,9-dion
Klinički podaci
Identifikatori
CAS broj	143413-68-7
ATC kod	nije dodeljen
PubChem	178132
ChemSpider	8002134
UNII	34E28BM822
Hemijski podaci
Formula	C26H38N2O4
Mol. masa	442,589 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C26H38N2O4.ClH/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26;/h8-10,20H,3-7,11-19H2,1-2H3;1H/t20-;/m0./s1 ; Key: QYFHCFNBYQZGKW-BDQAORGHSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Alnespiron (S-20,499) je selektivni pun agonist 5-HT_1A receptora iz azapironske hemijske klase.^[4]^[5]^[6] On ima antidepresivne i anksiolitičke efekte.^[4]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ ^4,0 ^4,1 Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J. (1992). „Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.”. Neuroreport. 3 (1): 84–86. DOI:10.1097/00001756-199201000-00022. PMID 1351756.
↑ Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J. (1992). „5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.”. Psychopharmacology (Berl). 108 (1-2): 47–50. DOI:10.1007/BF02245284. PMID 1357709.
↑ Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G. (2003). „In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.”. Eur J Pharmacol. 459 (1): 17–26. DOI:10.1016/S0014-2999(02)02814-5. PMID 12505530.

Vidi još[uredi | uredi kod]

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[pmid1351756-4] 4,0 ^4,1 Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J. (1992). „Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.”. Neuroreport. 3 (1): 84–86. DOI:10.1097/00001756-199201000-00022. PMID 1351756.

[pmid1357709-5] Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J. (1992). „5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.”. Psychopharmacology (Berl). 108 (1-2): 47–50. DOI:10.1007/BF02245284. PMID 1357709.

[pmid12505530-6] Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G. (2003). „In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.”. Eur J Pharmacol. 459 (1): 17–26. DOI:10.1016/S0014-2999(02)02814-5. PMID 12505530.

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Alnespiron

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