CSP-2503

Izvor: Wikipedia
CSP-2503
(IUPAC) ime
2-[(4-naftalen-1-ilpiperazin-1-il)metil]heksahidropirolo[1,2-a]pirazin-1,4-dion
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 10317515
ChemSpider[3] 8492979
ChEMBL[4] CHEMBL285066 YesY
Hemijski podaci
Formula C22H26N4O2 
Mol. masa 378,47 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

CSP-2503 je potentan i selektivan agonist 5-HT1A receptora, i antagonist 5-HT2A receptor i 5-HT3 receptora.[5] On je prvi put sintetisan 2003 koristeći dizajn baziran na računarskom modelu i QSAR studijama.[6][7] U istraživanjima na pacovima, CSP-2503 je pokazao anksiolitičko dejstvo, te je smatra da može da služi kao potencijalni tretman za anksioznost kod ljudi, sa multimodalnim mehanizmom dejstva.[5]

References[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  5. 5.0 5.1 Delgado M, Caicoya AG, Greciano V, et al. (March 2005). "Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors". European Journal of Pharmacology 511 (1): 9–19. doi:10.1016/j.ejphar.2005.01.032. PMID 15777774. 
  6. López-Rodríguez ML, Morcillo MJ, Fernández E, et al. (April 2003). "Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist". Bioorganic & Medicinal Chemistry Letters 13 (8): 1429–32. doi:10.1016/S0960-894X(03)00160-4. PMID 12668005. 
  7. López-Rodríguez ML, Morcillo MJ, Fernández E, et al. (April 2005). "Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors". Journal of Medicinal Chemistry 48 (7): 2548–58. doi:10.1021/jm048999e. PMID 15801844. 

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