CD117

V-kit Hardi-Zakerman 4, homolog mačijeg sarkoma viralnog onkogena
	; PDB prikaz baziran na 1pkg.
Dostupne strukture
	1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F
Identifikatori
Simboli	KIT; C-Kit; CD117; PBT; SCFR
Vanjski ID	OMIM: 164920 MGI: 96677 HomoloGene: 187 GeneCards: KIT Gene
EC broj	2.7.10.1
Ontologija gena
Molekularna funkcija	• vezivanje nukleotida; • vezivanje proteaza; • aktivnost proteinske tirozinske kinaze; • aktivnost transmembranskog receptora proteinske tirozinske kinaze; • aktivnost receptorskog signalnog proteina tirozinske kinaze; • receptorska aktivnost; • aktivnost faktora receptora stem ćelija; • proteinsko vezivanje; • ATP vezivanje; • citokinsko vezivanje; • aktivnost proteinske homodimerizacije; • vezivanje metalnog jona;
Celularna komponenta	• ekstracelularni prostor; • nukleus; • citoplazma; • ćelijska membrana; • spoljašnja strana ćelijske membrane; • integralno sa membranom;
Biološki proces	• aktivacija MAPK aktivnosti; • diferencijacija mijeloidnih progenitornih ćelija; • diferencijacija limfoidnih progenitornih ćelija; • glikosfingolipidni metabolički proces; • prenos signala; • signalni put transmembranskog receptora proteinske tirozinske kinaze; • kaskada intracelularne proteinske kinaze; • spermatogeneza; • razvoj spermatida; • pozitivna regulacija ćelijske proliferacije; • razvoj muških gonada; • respons na radijaciju; • pozitivna regulacija genske ekspresije; • pozitivna regulacija fosfolipaze C; • pozitivna regulacija kaskade fosfatidilinozitol 3-kinaze; • peptidil-tirozinska fosforilacija; • citokinom posredovani signalni put; • održavanje matičnih ćelija; • prenos signala fosforilacijom;
Ortolozi

edit

Receptor faktora rasta mastocita/matičnih ćelija (engl. Mast/stem cell growth factor receptor - SCFR), takođe poznat kao proto-onkogen c-Kit ili tirozinska proteinska kinaza Kit ili CD117, je protein koji je kod ljudi kodiran KIT genom.^[1] Višestruke transkriptne varijante koje kodiraju različite izoforme ovog gena su poznate.^[2] KIT prvi opisao nemački biohemičar Aksel Ulrič 1987. kao ćelijski homolog mačijeg sarkomnog viralnog onkogena v-kit.^[3]

Interakcije

CD117 formira interakcije sa:

Reference

↑ Andre C, Hampe A, Lachaume P, Martin E, Wang XP, Manus V, Hu WX, Galibert F (January 1997). „Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes”. Genomics 39 (2): 216–26. DOI:10.1006/geno.1996.4482. PMID 9027509.
↑ „Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog”.
↑ Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A (November 1987). „Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand”. EMBO J. 6 (11): 3341–51. PMC 553789. PMID 2448137.
↑ Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Rönnstrand L (March 2003). „The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit”. Biochem. J. 370 (Pt 3): 1033–8. DOI:10.1042/BJ20020716. PMC 1223215. PMID 12444928.
↑ Hallek M, Danhauser-Riedl S, Herbst R, Warmuth M, Winkler A, Kolb HJ, Druker B, Griffin JD, Emmerich B, Ullrich A (July 1996). „Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells”. Br. J. Haematol. 94 (1): 5–16. DOI:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502.
↑ ^6,0 ^6,1 ^6,2 Anzai N, Lee Y, Youn BS, Fukuda S, Kim YJ, Mantel C, Akashi M, Broxmeyer HE (June 2002). „C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors”. Blood 99 (12): 4413–21. DOI:10.1182/blood.V99.12.4413. PMID 12036870.
↑ ^7,0 ^7,1 Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (August 2003). „Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk”. Exp. Cell Res. 288 (1): 110–8. DOI:10.1016/S0014-4827(03)00206-4. PMID 12878163.
↑ ^8,0 ^8,1 van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). „Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–13. PMID 11071635.
↑ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). „Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)”. J. Biol. Chem. 272 (15): 10248–53. DOI:10.1074/jbc.272.15.10248. PMID 9092574.
↑ ^10,0 ^10,1 Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD (April 2002). „Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. J. Biol. Chem. 277 (16): 13732–8. DOI:10.1074/jbc.M200277200. PMID 11825908.
↑ ^11,0 ^11,1 Voisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P (February 2010). „FES kinase participates in KIT-ligand induced chemotaxis”. Biochem. Biophys. Res. Commun. 393 (1): 174–8. DOI:10.1016/j.bbrc.2010.01.116. PMID 20117079.
↑ Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). „Role for the adaptor protein Grb10 in the activation of Akt”. Mol. Cell. Biol. 22 (4): 979–91. DOI:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791.
↑ ^13,0 ^13,1 ^13,2 De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999). „Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation”. EMBO J. 18 (4): 904–15. DOI:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.
↑ Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L (July 1999). „Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor”. Biochem. J. 341 ( Pt 1): 211–6. DOI:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264.
↑ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). „Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway”. J. Biol. Chem. 271 (21): 12129–32. DOI:10.1074/jbc.271.21.12129. PMID 8647802.
↑ Lev S, Yarden Y, Givol D (May 1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. J. Biol. Chem. 267 (15): 10866–73. PMID 1375232.
↑ Blechman JM, Lev S, Brizzi MF, Leitner O, Pegoraro L, Givol D, Yarden Y (February 1993). „Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor”. J. Biol. Chem. 268 (6): 4399–406. PMID 7680037.
↑ Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP (October 2008). „Adaptor protein Lnk associates with Tyr(568) in c-Kit”. Biochem. J. 415 (2): 241–5. DOI:10.1042/BJ20080102. PMID 18588518.
↑ Linnekin D, DeBerry CS, Mou S (October 1997). „Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. J. Biol. Chem. 272 (43): 27450–5. DOI:10.1074/jbc.272.43.27450. PMID 9341198.
↑ Jhun BH, Rivnay B, Price D, Avraham H (April 1995). „The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit”. J. Biol. Chem. 270 (16): 9661–6. DOI:10.1074/jbc.270.16.9661. PMID 7536744.
↑ Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H (February 1997). „Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes”. J. Biol. Chem. 272 (9): 5915–20. DOI:10.1074/jbc.272.9.5915. PMID 9038210.
↑ Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Lett. 482 (1-2): 54–8. DOI:10.1016/S0014-5793(00)02036-6. PMID 11018522.
↑ Serve H, Hsu YC, Besmer P (February 1994). „Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells”. J. Biol. Chem. 269 (8): 6026–30. PMID 7509796.
↑ Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE (October 1994). „The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells”. J. Biol. Chem. 269 (40): 25206–11. PMID 7523381.
↑ ^25,0 ^25,1 Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA (April 1998). „SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain”. Mol. Cell. Biol. 18 (4): 2089–99. PMC 121439. PMID 9528781.
↑ Yi T, Ihle JN (June 1993). „Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand”. Mol. Cell. Biol. 13 (6): 3350–8. PMC 359793. PMID 7684496.
↑ Deberry C, Mou S, Linnekin D (October 1997). „Stat1 associates with c-kit and is activated in response to stem cell factor”. Biochem. J. 327 ( Pt 1): 73–80. PMC 1218765. PMID 9355737.
↑ Bayle J, Letard S, Frank R, Dubreuil P, De Sepulveda P (March 2004). „Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling”. J. Biol. Chem. 279 (13): 12249–59. DOI:10.1074/jbc.M313381200. PMID 14707129.
↑ Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, Rönnstrand L (September 1999). „Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction”. Oncogene 18 (40): 5546–53. DOI:10.1038/sj.onc.1202929. PMID 10523831.
↑ Tang B, Mano H, Yi T, Ihle JN (December 1994). „Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding”. Mol. Cell. Biol. 14 (12): 8432–7. PMC 359382. PMID 7526158.

Literatura

Lennartsson J, Rönnstrand L (2006). „The stem cell factor receptor/c-Kit as a drug target in cancer”. Curr. Cancer Drug Targ. 6 (1): 65–75. DOI:10.2174/156800906775471725. PMID 16475976.
Rönnstrand L (2004). „Signal transduction via the stem cell factor receptor/c-Kit”. Cell. Mol. Life Sci. 61 (19–20): 2535–2548. DOI:10.1007/s00018-004-4189-6. PMID 15526160.
Linnekin D (2000). „Early signaling pathways activated by c-Kit in hematopoietic cells”. Int. J. Biochem. Cell Biol. 31 (10): 1053–74. DOI:10.1016/S1357-2725(99)00078-3. PMID 10582339.
Canonico B, Felici C, Papa S (2001). „CD117”. J. Biol. Regul. Homeost. Agents 15 (1): 90–4. PMID 11388751.
Gupta R, Bain BJ, Knight CL (2002). „Cytogenetic and molecular genetic abnormalities in systemic mastocytosis”. Acta Haematol. 107 (2): 123–8. DOI:10.1159/000046642. PMID 11919394.
Valent P, Ghannadan M, Hauswirth AW, et al. (2003). „Signal transduction-associated and cell activation-linked antigens expressed in human mast cells”. Int. J. Hematol. 75 (4): 357–62. DOI:10.1007/BF02982124. PMID 12041664.
Sandberg AA, Bridge JA (2002). „Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors”. Cancer Genet. Cytogenet. 135 (1): 1–22. DOI:10.1016/S0165-4608(02)00546-0. PMID 12072198.
Kitamura Y, Hirotab S (2005). „Kit as a human oncogenic tyrosine kinase”. Cell. Mol. Life Sci. 61 (23): 2924–31. DOI:10.1007/s00018-004-4273-y. PMID 15583854.
Larizza L, Magnani I, Beghini A (2005). „The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia”. Leuk. Lymphoma 46 (2): 247–55. DOI:10.1080/10428190400007565. PMID 15621809.
Miettinen M, Lasota J (2006). „KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation”. Appl. Immunohistochem. Mol. Morphol. 13 (3): 205–20. PMID 16082245.
Lasota J, Miettinen M (2007). „KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)”. Semin Diagn Pathol 23 (2): 91–102. DOI:10.1053/j.semdp.2006.08.006. PMID 17193822.
Patnaik MM, Tefferi A, Pardanani A (2007). „Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders”. Current cancer drug targets 7 (5): 492–503. DOI:10.2174/156800907781386614. PMID 17691909.
Giebel LB, Strunk KM, Holmes SA, Spritz RA (1992). „Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene”. Oncogene 7 (11): 2207–17. PMID 1279499.
Spritz RA, Droetto S, Fukushima Y (1992). „Deletion of the KIT and PDGFRA genes in a patient with piebaldism”. Am. J. Med. Genet. 44 (4): 492–5. DOI:10.1002/ajmg.1320440422. PMID 1279971.
Spritz RA, Giebel LB, Holmes SA (1992). „Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism”. Am. J. Hum. Genet. 50 (2): 261–9. PMC 1682440. PMID 1370874.
Duronio V, Welham MJ, Abraham S, et al. (1992). „p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein”. Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1587–91. DOI:10.1073/pnas.89.5.1587. PMC 48497. PMID 1371879.
André C, Martin E, Cornu F, et al. (1992). „Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III”. Oncogene 7 (4): 685–91. PMID 1373482.
Lev S, Yarden Y, Givol D (1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. J. Biol. Chem. 267 (15): 10866–73. PMID 1375232.
Fleischman RA (1992). „Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene”. J. Clin. Invest. 89 (6): 1713–7. DOI:10.1172/JCI115772. PMC 295855. PMID 1376329.
Vandenbark GR, deCastro CM, Taylor H, et al. (1992). „Cloning and structural analysis of the human c-kit gene”. Oncogene 7 (7): 1259–66. PMID 1377810.
Alai M, Mui AL, Cutler RL, et al. (1992). „Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells”. J. Biol. Chem. 267 (25): 18021–5. PMID 1381360.
Ashman LK, Cambareri AC, To LB, et al. (1991). „Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow”. Blood 78 (1): 30–7. PMID 1712644.

Povezano

Citokinski receptor

Vanjske veze

MeSH Proto-Oncogene+Proteins+c-kit
C-kit receptor Arhivirano 2009-05-10 na Wayback Machine-u

[pmid9027509-1] Andre C, Hampe A, Lachaume P, Martin E, Wang XP, Manus V, Hu WX, Galibert F (January 1997). „Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes”. Genomics 39 (2): 216–26. DOI:10.1006/geno.1996.4482. PMID 9027509.

[entrez-2] „Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog”.

[pmid2448137-3] Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A (November 1987). „Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand”. EMBO J. 6 (11): 3341–51. PMC 553789. PMID 2448137.

[pmid12444928-4] Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Rönnstrand L (March 2003). „The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit”. Biochem. J. 370 (Pt 3): 1033–8. DOI:10.1042/BJ20020716. PMC 1223215. PMID 12444928.

[pmid8757502-5] Hallek M, Danhauser-Riedl S, Herbst R, Warmuth M, Winkler A, Kolb HJ, Druker B, Griffin JD, Emmerich B, Ullrich A (July 1996). „Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells”. Br. J. Haematol. 94 (1): 5–16. DOI:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502.

[pmid12036870-6] 6,0 ^6,1 ^6,2 Anzai N, Lee Y, Youn BS, Fukuda S, Kim YJ, Mantel C, Akashi M, Broxmeyer HE (June 2002). „C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors”. Blood 99 (12): 4413–21. DOI:10.1182/blood.V99.12.4413. PMID 12036870.

[pmid12878163-7] 7,0 ^7,1 Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (August 2003). „Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk”. Exp. Cell Res. 288 (1): 110–8. DOI:10.1016/S0014-4827(03)00206-4. PMID 12878163.

[pmid11071635-8] 8,0 ^8,1 van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). „Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–13. PMID 11071635.

[pmid9092574-9] Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). „Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)”. J. Biol. Chem. 272 (15): 10248–53. DOI:10.1074/jbc.272.15.10248. PMID 9092574.

[pmid11825908-10] 10,0 ^10,1 Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD (April 2002). „Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. J. Biol. Chem. 277 (16): 13732–8. DOI:10.1074/jbc.M200277200. PMID 11825908.

[pmid20117079-11] 11,0 ^11,1 Voisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P (February 2010). „FES kinase participates in KIT-ligand induced chemotaxis”. Biochem. Biophys. Res. Commun. 393 (1): 174–8. DOI:10.1016/j.bbrc.2010.01.116. PMID 20117079.

[pmid11809791-12] Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). „Role for the adaptor protein Grb10 in the activation of Akt”. Mol. Cell. Biol. 22 (4): 979–91. DOI:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791.

[pmid10022833-13] 13,0 ^13,1 ^13,2 De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999). „Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation”. EMBO J. 18 (4): 904–15. DOI:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.

[pmid10377264-14] Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L (July 1999). „Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor”. Biochem. J. 341 ( Pt 1): 211–6. DOI:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264.

[pmid8647802-15] Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). „Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway”. J. Biol. Chem. 271 (21): 12129–32. DOI:10.1074/jbc.271.21.12129. PMID 8647802.

[pmid1375232-16] Lev S, Yarden Y, Givol D (May 1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. J. Biol. Chem. 267 (15): 10866–73. PMID 1375232.

[pmid7680037-17] Blechman JM, Lev S, Brizzi MF, Leitner O, Pegoraro L, Givol D, Yarden Y (February 1993). „Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor”. J. Biol. Chem. 268 (6): 4399–406. PMID 7680037.

[pmid18588518-18] Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP (October 2008). „Adaptor protein Lnk associates with Tyr(568) in c-Kit”. Biochem. J. 415 (2): 241–5. DOI:10.1042/BJ20080102. PMID 18588518.

[pmid9341198-19] Linnekin D, DeBerry CS, Mou S (October 1997). „Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. J. Biol. Chem. 272 (43): 27450–5. DOI:10.1074/jbc.272.43.27450. PMID 9341198.

[pmid7536744-20] Jhun BH, Rivnay B, Price D, Avraham H (April 1995). „The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit”. J. Biol. Chem. 270 (16): 9661–6. DOI:10.1074/jbc.270.16.9661. PMID 7536744.

[pmid9038210-21] Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H (February 1997). „Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes”. J. Biol. Chem. 272 (9): 5915–20. DOI:10.1074/jbc.272.9.5915. PMID 9038210.

[pmid11018522-22] Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Lett. 482 (1-2): 54–8. DOI:10.1016/S0014-5793(00)02036-6. PMID 11018522.

[pmid7509796-23] Serve H, Hsu YC, Besmer P (February 1994). „Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells”. J. Biol. Chem. 269 (8): 6026–30. PMID 7509796.

[pmid7523381-24] Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE (October 1994). „The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells”. J. Biol. Chem. 269 (40): 25206–11. PMID 7523381.

[pmid9528781-25] 25,0 ^25,1 Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA (April 1998). „SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain”. Mol. Cell. Biol. 18 (4): 2089–99. PMC 121439. PMID 9528781.

[pmid7684496-26] Yi T, Ihle JN (June 1993). „Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand”. Mol. Cell. Biol. 13 (6): 3350–8. PMC 359793. PMID 7684496.

[pmid9355737-27] Deberry C, Mou S, Linnekin D (October 1997). „Stat1 associates with c-kit and is activated in response to stem cell factor”. Biochem. J. 327 ( Pt 1): 73–80. PMC 1218765. PMID 9355737.

[pmid14707129-28] Bayle J, Letard S, Frank R, Dubreuil P, De Sepulveda P (March 2004). „Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling”. J. Biol. Chem. 279 (13): 12249–59. DOI:10.1074/jbc.M313381200. PMID 14707129.

[pmid10523831-29] Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, Rönnstrand L (September 1999). „Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction”. Oncogene 18 (40): 5546–53. DOI:10.1038/sj.onc.1202929. PMID 10523831.

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p r u Proteini: klasteri diferencijacije (vidi isto spisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350

p r u Receptori: Receptori faktora rasta
Nervni faktori rasta	niski afinitet/p75 - visok afinitet Trk (TrkA, TrkB, TrkC) - Cilijarni neurotrofni faktor
Somatomedin	Insulinu-sličan faktor rasta 1 - Insulinu-sličan faktor rasta 2
CSF	Stem ćelijski faktor - Eritropoietin
TGF put	TGF-beta (1, 2) - Aktivin (1, 2) - Bone morfogenetski protein (1, 2)
Drugi	Hepatocitni faktor rasta - ErbB/Epidermalni faktor rasta - Fibroblast faktor rasta (1, 2, 3, 4) - Trombocit-izvedeni faktor rasta (A, B) - VEGF (1, 2, 3)
vidi isto Faktori rasta
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

p r u Proteini: enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6