P-glikoprotein

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ATP-vezujuća kaseta, potfamilija B (MDR/TAP), član 1

Kristalografska struktura MDR3 proteina miša. Aproksimativna pozicija proteina u ćelijskoj membrani je obeležena plavim (ekstracelularno lice) i crvenim (citoplazmatično lice) linijama. Protein je prikaza u bojama duge (N-terminus = plavo, C-terminus = crveno). Ciklični peptidni inhibitor QZ59 je prikazan kao prostorno popunjavajući model.[1]
Dostupne strukture
3G5U, 3G60, 3G61
Identifikatori
SimboliABCB1; ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1
Vanjski IDOMIM171050 MGI97570 HomoloGene55496 GeneCards: ABCB1 Gene
EC broj3.6.3.44
Pregled RNK izražavanja
PBB GE ABCB1 209994 s at tn.png
PBB GE ABCB1 209993 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez524318671
EnsemblENSG00000085563ENSMUSG00000040584
UniProtP08183P21447
RefSeq (mRNA)NM_000927.4NM_011076.2
RefSeq (protein)NP_000918.2NP_035206.2
Lokacija (UCSC)Chr 7:
87.13 - 87.34 Mb
Chr 5:
8.66 - 8.75 Mb
PubMed pretraga[1][2]

P-glikoprotein 1 (glikoprotein permeabilnosti, P-gp, Pgp, protein otpornosti na višestruke lekove 1, MDR1, ATP-vezujuća kaseta potfamilija B član 1, ABCB1, klaster of diferencijacije 243, CD243) je glikoprotein koji je kod ljudi kodiran ABCB1 genom.[2] P-gp dobro poznati ABC-transporter (koji transportuje široki opseg supstrata kroz ekstra- i intracelularne membrane). On je član MDR/TAP familije.[3]

Pgp je široko rasprostranjen i izražen u interstinalnom epitelu, hepatocitima, renalno proksimalno tubularnim ćelijama, nadbubrežnoj žlezdi i kapilarnim endotelnim ćelijama od kojih je formirana krvno-moždana i krvno-testikularna barijera.

Reference[uredi - уреди | uredi izvor]

  1. PDB 3G60; Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G (March 2009). "Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding". Science 323 (5922): 1718–22. PMC 2720052. PMID 19325113. doi:10.1126/science.1168750. 
  2. Ueda K, Clark DP, Chen CJ, Roninson IB, Michael M. Gottesman, Pastan I (January 1987). "The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation". J. Biol. Chem. 262 (2): 505–8. PMID 3027054. 
  3. Dean, Michael (1. 11. 2002.). "The Human ATP-Binding Cassette (ABC) Transporter Superfamily". National Library of Medicine (US), NCBI. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mono_001.chapter.137. pristupljeno 2. 3. 2008.. 

Literatura[uredi - уреди | uredi izvor]

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  • Brinkmann U (2002). "Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo". Novartis Found. Symp. Novartis Foundation Symposia 243: 207–10; discussion 210–2, 231–5. ISBN 978-0-470-84635-3. PMID 11990778. doi:10.1002/0470846356.ch15. 
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  • Kumar YS, Adukondalu D, Sathish D, Vishnu YV, Ramesh G, Latha AB, Reddy PC, Sarangapani M, Rao YM (2010). "P-Glycoprotein- and cytochrome P-450-mediated herbal drug interactions". Drug Metabol Drug Interact 25 (1-4): 3–16. PMID 21417789. doi:10.1515/DMDI.2010.006. 

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