Glutamilna aminopeptidaza

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(Preusmjereno sa Glutamil aminopeptidaza)
Glutamilna aminopeptidaza
Identifikatori
EC broj 3.4.11.7
CAS broj 9074-83-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glutamilna aminopeptidaza (EC 3.4.11.7, aminopeptidaza A, aspartatna aminopeptidaza, angiotensinaza A, glutamilna peptidaza, Ca2+-aktivirana glutamatna aminopeptidaza, membranska aminopeptidaza II, antigen BP-1/6C3 mišjeg B limfocita, L-aspartatna aminopeptidaza, angiotensinaza A2) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje N-terminalnog glutamata (i u manjoj meri aspartata) sa peptida

Ovaj enzim aktiviraju joni Ca2+. On je najčešće vezan za membranu.

Reference[uredi - уреди | uredi izvor]

  1. Glenner, G.G., McMillan, P.J. and Folk, J.E. (1962). "A mammalian peptidase specific for the hydrolysis of N-terminal α-L-glutamyl and aspartyl residues". Nature 194: 867–867. PMID 13899213. 
  2. Chulkova, T.M. and Orekhovich, V.N. (1978). "Isolation and properties of aminopeptidase A from bovine kidneys". Biokhimiya 43: 964–969. PMID 508862. 
  3. Danielsen, E.M., Norén, O., Sjöström, H., Ingram, J. and Kenny, J. (1980). "Proteins of the kidney microvillar membrane. Aspartate aminopeptidase: purification by immunoadsorbent chromatography and properties of the detergent- and proteinase-solubilized forms". Biochem. J. 189: 591–603. PMID 7011318. 
  4. Tobe, H., Kojima, F., Aoyagi, T. and Umezawa, H. (1980). "Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney". Biochim. Biophys. Acta 613: 459–468. PMID 7448199. 
  5. Wu, Q., Lahti, J.M., Air, G.M., Burrows, P.D. and Cooper, M.D. (1990). "Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family". Proc. Natl Acad. Sci. USA 87: 993–997. PMID 1689065. 

Literatura[uredi - уреди | uredi izvor]

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