TFRC

Iz Wikipedije, slobodne enciklopedije
Idi na navigaciju Idi na pretragu
edit
Transferinski receptor (p90, CD71)

PDB prikaz baziran na 1cx8.
Dostupne strukture
1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N
Identifikatori
SimboliTFRC; CD71; T9; TFR; TFR1; TR; TRFR; p90
Vanjski IDOMIM190010 MGI98822 HomoloGene2429 GeneCards: TFRC Gene
Pregled RNK izražavanja
PBB GE TFRC 208691 at tn.png
PBB GE TFRC 207332 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez703722042
EnsemblENSG00000072274ENSMUSG00000022797
UniProtP02786Q62351
RefSeq (mRNA)NM_001128148.1NM_011638.4
RefSeq (protein)NP_001121620.1NP_035768.1
Lokacija (UCSC)Chr 3:
195.75 - 195.81 Mb
Chr 16:
32.61 - 32.63 Mb
PubMed pretraga[1][2]

Transferinski receptor 1 (TfR1, Klaster diferencijacije 71, CD71) je protein koji je kod ljudi kodiran TFRC genom.[1][2] TfR1 je neohodan za prenos gvožđa vezanog za transferin u ćelije.[3][4]

Interakcije[uredi - уреди | uredi izvor]

TFRC formira interakcije sa GABARAP[5] i HFE.[6][7]

Reference[uredi - уреди | uredi izvor]

  1. Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). "Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. PMC 319822. PMID 6270680. doi:10.1073/pnas.78.7.4515. 
  2. Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). "Regional localization of the human transferrin receptor gene to 3q26.2----qter". Am. J. Hum. Genet. 37 (6): 1112–6. PMC 1684729. PMID 3002171. 
  3. Aisen P (November 2004). "Transferrin receptor 1". Int. J. Biochem. Cell Biol. 36 (11): 2137–43. PMID 15313461. doi:10.1016/j.biocel.2004.02.007. 
  4. Moos T (November 2002). "Brain iron homeostasis". Danish Medical Bulletin 49 (4): 279–301. PMID 12553165. 
  5. Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Lett. 518 (1–3): 101–6. PMID 11997026. doi:10.1016/S0014-5793(02)02655-8. 
  6. Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). "The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. PMC 19050. PMID 9465039. doi:10.1073/pnas.95.4.1472. 
  7. West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE". J. Biol. Chem. 275 (49): 38135–8. PMID 11027676. doi:10.1074/jbc.C000664200. 

Vidi još[uredi - уреди | uredi izvor]