PTK7

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Protein tirozinske kinaze 7
Identifikatori
SimboliPTK7; CCK-4; CCK4
Vanjski IDOMIM601890 MGI1918711 HomoloGene43672 GeneCards: PTK7 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE PTK7 207011 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez575471461
EnsemblENSG00000112655ENSMUSG00000023972
UniProtQ13308Q8BKG3
Ref. Sekv. (iRNK)NM_001270398NM_175168
Ref. Sekv. (protein)NP_001257327NP_780377
Lokacija (UCSC)Chr 6:
43.04 - 43.13 Mb
Chr 17:
46.56 - 46.63 Mb
PubMed pretraga[1][2]

Receptor sličan tirozinskoj proteinskoj kinazi 7 je enzim koji je kod ljudi kodiran PTK7 genom.[1][2]

Receptorske proteinske tirozinske kinaze prenose ekstracelularne signale kroz ćelijsku membranu. Jednoj podgrupi tih kinaza nedostaje primetna katalitička aktivnost tirozinske kinaze, mada zadržavaju ulogu u prenosu signala. Protein kodiran ovim genom ima intracelularni domen koji je hologan sa tirozinskim kinazama. Smatra se da on deluje kao ćelijski adhezioni molekul. Ovaj gen se izražava u karcinomima debelog creva, a nije prisutan u normalnim ćelijama debelog creva, i stoga je jedan od markera progresije tumora. Poznate su četiri transkriptne varijante koje kodiraju četiri različite izoforme.[2]

Reference[uredi - уреди | uredi izvor]

  1. Mossie K, Jallal B, Alves F, Sures I, Plowman GD, Ullrich A (Dec 1995). "Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family". Oncogene 11 (10): 2179–84. PMID 7478540.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: PTK7 PTK7 protein tyrosine kinase 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5754. 

Literatura[uredi - уреди | uredi izvor]

  • Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene 8 (12): 3403–10. PMID 8247543. 
  • Park SK, Lee HS, Lee ST (1997). "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.". J. Biochem. 119 (2): 235–9. PMID 8882711. doi:10.1093/oxfordjournals.jbchem.a021228. 
  • Banga SS, Ozer HL, Park SK, Lee ST (1997). "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1→p12.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 76 (1–2): 43–4. PMID 9154124. doi:10.1159/000134511. 
  • Jung JW; Ji AR; Lee J et al. (2003). "Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA". Biochim. Biophys. Acta 1579 (2–3): 153–63. PMID 12427550. doi:10.1016/s0167-4781(02)00536-5. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. PMID 12754519. doi:10.1038/nbt827. 
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Kobus FJ, Fleming KG (2005). "The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions". Biochemistry 44 (5): 1464–70. PMID 15683231. doi:10.1021/bi048076l. 
  • Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells". Int. J. Mol. Med. 20 (3): 405–9. PMID 17671748. doi:10.3892/ijmm.20.3.405.