Janus kinaza 3

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Janus kinaza 3

PDB prikaz baziran na 1yvj.
Dostupne strukture
1YVJ, 3LXK, 3LXL, 3PJC, 3ZC6, 3ZEP, 4HVD, 4HVG, 4HVH, 4HVI, 4I6Q
Identifikatori
SimboliJAK3; JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK
Vanjski IDOMIM600173 MGI99928 HomoloGene181 GeneCards: JAK3 Gene
EC broj2.7.10.2
Ortolozi
VrstaČovekMiš
Entrez371816453
EnsemblENSG00000105639ENSMUSG00000031805
UniProtP52333Q62137
Ref. Sekv. (iRNK)NM_000215NM_001190830
Ref. Sekv. (protein)NP_000206NP_001177759
Lokacija (UCSC)Chr 19:
17.94 - 17.96 Mb
Chr 8:
71.68 - 71.69 Mb
PubMed pretraga[1][2]

Tirozinska proteinska kinaza JAK3 je enzim koji je kod ljudi kodiran JAK3 genom.[1][2]

Regulacija[uredi - уреди | uredi izvor]

Janus kinaza 3 formira interakcije sa CD247,[3] TIAF1[4] i IL2RG.[5][6]

Reference[uredi - уреди | uredi izvor]

  1. Riedy MC, Dutra AS, Blake TB, Modi W, Lal BK, Davis J, Bosse A, O'Shea JJ, Johnston JA (February 1997). "Genomic sequence, organization, and chromosomal localization of human JAK3". Genomics 37 (1): 57–61. PMID 8921370. doi:10.1006/geno.1996.0520. 
  2. Hoffman SM, Lai KS, Tomfohrde J, Bowcock A, Gordon LA, Mohrenweiser HW (September 1997). "JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors". Genomics 43 (1): 109–11. PMID 9226382. doi:10.1006/geno.1997.4792. 
  3. Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (July 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. PMID 11349123. doi:10.1074/jbc.M011363200. 
  4. Ji H, Zhai Q, Zhu J, Yan M, Sun L, Liu X, Zheng Z (April 2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochem. Biophys. Res. Commun. 270 (1): 267–71. PMID 10733938. doi:10.1006/bbrc.2000.2413. 
  5. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science 266 (5187): 1045–7. PMID 7973659. doi:10.1126/science.7973659. 
  6. Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science 266 (5187): 1042–5. PMID 7973658. doi:10.1126/science.7973658. 

Literatura[uredi - уреди | uredi izvor]

  • Notarangelo LD, Mella P, Jones A, de Saint Basile G, Savoldi G, Cranston T, Vihinen M, Schumacher RF (October 2001). "Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency". Hum. Mutat. 18 (4): 255–63. PMID 11668610. doi:10.1002/humu.1188. 
  • Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckley RH, O'Shea JJ, Leonard WJ (November 1995). "Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development". Science 270 (5237): 797–800. PMID 7481768. doi:10.1126/science.270.5237.797. 
  • Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases". J. Biol. Chem. 270 (48): 28527–30. PMID 7499365. doi:10.1074/jbc.270.48.28527. 
  • Musso T, Johnston JA, Linnekin D, Varesio L, Rowe TK, O'Shea JJ, McVicar DW (April 1995). "Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7". J. Exp. Med. 181 (4): 1425–31. PMC 2191962. PMID 7535338. doi:10.1084/jem.181.4.1425. 
  • Rolling C, Treton D, Beckmann P, Galanaud P, Richard Y (May 1995). "JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering". Oncogene 10 (9): 1757–61. PMID 7538655. 
  • Lai KS, Jin Y, Graham DK, Witthuhn BA, Ihle JN, Liu ET (October 1995). "A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells". J. Biol. Chem. 270 (42): 25028–36. PMID 7559633. doi:10.1074/jbc.270.42.25028. 
  • Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, Ugazio AG, Johnston JA, Candotti F, O'Shea JJ (September 1995). "Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)". Nature 377 (6544): 65–8. PMID 7659163. doi:10.1038/377065a0. 
  • Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science 266 (5187): 1042–5. PMID 7973658. doi:10.1126/science.7973658. 
  • Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science 266 (5187): 1045–7. PMID 7973659. doi:10.1126/science.7973659. 
  • Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, O'Shea JJ (July 1994). "Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2". Nature 370 (6485): 151–3. PMID 8022485. doi:10.1038/370151a0. 
  • Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN (July 1994). "Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells". Nature 370 (6485): 153–7. PMID 8022486. doi:10.1038/370153a0. 
  • Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR (July 1994). "Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6374–8. PMC 44204. PMID 8022790. doi:10.1073/pnas.91.14.6374. 
  • Verbsky JW, Bach EA, Fang YF, Yang L, Randolph DA, Fields LE (June 1996). "Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells". J. Biol. Chem. 271 (24): 13976–80. PMID 8662778. doi:10.1074/jbc.271.24.13976. 
  • Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J (March 1997). "Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling". J. Biol. Chem. 272 (10): 6214–9. PMID 9045636. doi:10.1074/jbc.272.10.6214. 
  • Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene 14 (7): 751–61. PMID 9047382. doi:10.1038/sj.onc.1200907. 
  • Safford MG, Levenstein M, Tsifrina E, Amin S, Hawkins AL, Griffin CA, Civin CI, Small D (May 1997). "JAK3: expression and mapping to chromosome 19p12-13.1". Exp. Hematol. 25 (5): 374–86. PMID 9168059. 
  • Sharfe N, Dadi HK, O'Shea JJ, Roifman CM (June 1997). "Jak3 activation in human lymphocyte precursor cells". Clin. Exp. Immunol. 108 (3): 552–6. PMC 1904698. PMID 9182906. doi:10.1046/j.1365-2249.1997.4001304.x. 
  • Candotti F, Oakes SA, Johnston JA, Giliani S, Schumacher RF, Mella P, Fiorini M, Ugazio AG, Badolato R, Notarangelo LD, Bozzi F, Macchi P, Strina D, Vezzoni P, Blaese RM, O'Shea JJ, Villa A (November 1997). "Structural and functional basis for JAK3-deficient severe combined immunodeficiency". Blood 90 (10): 3996–4003. PMID 9354668. 

Vanjske veze[uredi - уреди | uredi izvor]