Serin/treoninska proteinska kinaza LMTK1
(Preusmjereno sa stranice AATK)
| edit |
| Tirozinska kinaza asocirana sa apoptozom | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | AATK; AATYK; AATYK1; LMR1; LMTK1; PPP1R77; p35BP | ||||||||||
| Vanjski ID | OMIM: 605276 MGI: 1197518 HomoloGene: 74861 GeneCards: AATK Gene | ||||||||||
| EC broj | 2.7.11.1 | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9625 | 11302 | |||||||||
| Ensembl | ENSG00000181409 | ENSMUSG00000025375 | |||||||||
| UniProt | Q6ZMQ8 | Q80YE4 | |||||||||
| Ref. Sekv. (iRNK) | NM_001080395 | NM_001198785 | |||||||||
| Ref. Sekv. (protein) | NP_001073864 | NP_001185714 | |||||||||
| Lokacija (UCSC) | Chr 17: 79.09 - 79.14 Mb | Chr 11: 120.01 - 120.05 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Serin/treoninska proteinska kinaza LMTK1 (takođe poznata kao tirozinska kinaza asocirana sa apoptozom) je enzim koji je kod ljudi kodiran (AATK) genom.[1][2][3]
Ovaj gen je identifikovan 1998. On je lociran na hromozomu 17 (17q25.3) i izražava se u pankreasu, bubrezima, mozgu i plućima. Protein se sastoji od 1.207 aminokiselina.[1][2]
Ovaj protein se sastoji od tirozinskog kinaznog domena na N-terminusnom kraju i prolinom bogatog domena na C-terminusnom kraju. Studije mišjeg homoga indiciraju da je on verovatno neophodan za indukciju zaustavljanja rasta i/ili apoptozu mijeloidnih prekursornih ćelija. On takođe učestvuje u indukciji diferencijacije u neuronskim ćelijama.[4][3] Nedavno je objavljeno da ima supresivnu ulogu u razvoju melanoma.[5]
Smatra se da AATK indirektno inhibira SPAK/WNK4 aktivaciju Na-K-Cl kotransportera.[6]
- ↑ 1,0 1,1 Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). „Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Res 5 (3): 169–76. DOI:10.1093/dnares/5.3.169. PMID 9734811.
- ↑ 2,0 2,1 Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). „Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization”. J Hum Genet 44 (2): 141–2. DOI:10.1007/s100380050130. PMID 10083745.
- ↑ 3,0 3,1 „Entrez Gene: AATK apoptosis-associated tyrosine kinase”.
- ↑ DOI:10.1371/journal.pone.0031022
This citation will be automatically completed in the next few minutes. You can jump the queue or expand by hand - ↑ Ma S (Apr 2014). „Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma.”. Lab Invest. 94 (4): 430-438. DOI:10.1038/labinvest.2014.13. PMID 24589855.
- ↑ DOI:10.1152/ajpcell.00580.2006
This citation will be automatically completed in the next few minutes. You can jump the queue or expand by hand
- Nakajima D, Okazaki N, Yamakawa H i dr.. (2003). „Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones”. DNA Res. 9 (3): 99–106. DOI:10.1093/dnares/9.3.99. PMID 12168954.
- Raghunath M, Patti R, Bannerman P i dr.. (2000). „A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line”. Brain Res. Mol. Brain Res. 77 (2): 151–62. DOI:10.1016/S0169-328X(00)00048-6. PMID 10837911.
- DOI:10.1073/pnas.242603899
This citation will be automatically completed in the next few minutes. You can jump the queue or expand by hand - Tomomura M, Hasegawa Y, Hashikawa T i dr.. (2003). „Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain”. Brain Res. Mol. Brain Res. 112 (1–2): 103–12. DOI:10.1016/S0169-328X(03)00054-8. PMID 12670708.
- Honma N, Asada A, Takeshita S i dr.. (2003). „Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein”. Biochem. Biophys. Res. Commun. 310 (2): 398–404. DOI:10.1016/j.bbrc.2003.08.143. PMID 14521924.
- Piechotta K, Garbarini N, England R, Delpire E (2004). „Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl− cotransporter in the nervous system: evidence for a scaffolding role of the kinase”. J. Biol. Chem. 278 (52): 52848–56. DOI:10.1074/jbc.M309436200. PMID 14563843.
- Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.