Src (gen)

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V-src sarkoma viralni onkogeni homolog (avijarni)

PDB prikaz baziran na 1a07.
Dostupne strukture
1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e, 1bkl, 1bkm, 1f1w, 1f2f, 1fmk, 1hcs, 1hct, 1is0, 1kc2, 1ksw, 1nlo, 1nlp, 1nzl, 1nzv, 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r, 1p13, 1prl, 1prm, 1qwe, 1qwf, 1rlp, 1rlq, 1sha, 1shb, 1shd, 1skj, 1spr, 1sps, 1srl, 1srm, 1y57, 1yi6, 1yoj, 1yol, 1yom, 2bdf, 2bdj, 2h8h, 2hwo, 2hwp, 2oiq, 2ptk, 2src
Identifikatori
SimboliSRC; ASV; SRC1; c-SRC; p60-Src
Vanjski IDOMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez671420779
EnsemblENSG00000197122ENSMUSG00000027646
UniProtP12931Q2M4I4
RefSeq (mRNA)NM_005417NM_001025395
RefSeq (protein)NP_005408NP_001020566
Lokacija (UCSC)Chr 20:
35.41 - 35.47 Mb		Chr 2:
157.12 - 157.16 Mb
PubMed pretraga[1][2]

Src je proto-onkogenska tirozinska kinaza. Src su otkrili Mihael Bišop i Harold Varmus. Za ovo otkriće im je dodeljena Nobelova nagrada za fiziologiju ili medicinu 1989. godine.[1] Ova kinaza pripada familiji nespecifičnih proteinskih tirozinskih kinaza koja se naziva Src familijom kinaza. Otkriće Src porodice proteina je imalo presudnu ulogu u modernom shvatanju rak kao bolesti u kojoj se inače zdrava ćelijska signalizacija pokvari.

Ovaj gen je sličan sa v-src genom Rous sarkoma virusa. Ovaj proto-onkogen može da igra ulogu u regulisanju embrionalnog razvoja i rasta ćelija. Proteinska kinaza koju ovaj gen kodira se može inhibirati fosforilacijom c-SRC kinazom. Mutacije ovog gena mogu da učestvuju u malignom razvoju raka debelog creva. Dve transkriptne varijante koje kodiraju isti protein su nađene za ovaj gen.[2]

Interactions[uredi | uredi kod]

Za Src gen je bilo pokazano da interaguje sa GRIN2A,[3][4] C-Raf,[5] CD44,[6] Jedreni translokator arilnog ugljovodoničnog receptora,[7] Aryl hydrocarbon receptor,[7] PDE6G,[8] STAT1,[9][10] EPH receptor B2,[11][12] Androgenski receptor,[13][14][15] Proteinska kinaza Mζ,[16] STAT3,[17] Grb2,[8][18] Beta-3 adrenergički receptor,[19] Kinaza beta adrenergičkog receptora,[8] Receptor epidermalnog faktora rasta,[9][20][21] PTK2,[22][23][24][25][26][27] DAB2,[28] EPS8,[29] Distroglikan,[30] Estrogenski receptor alfa,[13][31][32][33] Estrogenski receptor beta,[13][33] HNF1A,[34] KHDRBS1,[35][36][37][38][39] DDEF1,[40] MUC1,[41][42] PTK2B,[20][43][44] BCAR1,[45][22][46][47][48][24] SHB,[49] PLD2,[50] Faktor responsa seruma,[51] NCOA6,[52][53][54][55] Receptor retinoiske kiseline alfa,[32][56] Protein Viskot-Oldrić sindroma,[57][58] RICS,[59] RAS p21 proteinski activator 1,[60][61] MT-ND2[62] i GNB2L1.[63]

Reference[uredi | uredi kod]

  1. ↑ Nobel Prize in Physiology or Medicine for 1989 jointly to J. Michael Bishop and Harold E. Varmus for their discovery of "the cellular origin of retroviral oncogenes". Press Release.
  2. ↑ „Entrez Gene: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)”. 
  3. ↑ Ma, Juan; Zhang Guang-Yi (September 2003). „Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia”. Neurosci. Lett. (Ireland) 348 (3): 185–9. DOI:10.1016/S0304-3940(03)00784-5. ISSN 0304-3940. PMID 12932824. 
  4. ↑ Takagi, N; Cheung H H, Bissoon N, Teves L, Wallace M C, Gurd J W (August 1999). „The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains”. J. Cereb. Blood Flow Metab. (UNITED STATES) 19 (8): 880–8. DOI:10.1097/00004647-199908000-00007. ISSN 0271-678X. PMID 10458595. 
  5. ↑ Cleghon, V; Morrison D K (July 1994). „Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner”. J. Biol. Chem. (UNITED STATES) 269 (26): 17749–55. ISSN 0021-9258. PMID 7517401. 
  6. ↑ Bourguignon, L Y; Zhu H, Shao L, Chen Y W (March 2001). „CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration”. J. Biol. Chem. (United States) 276 (10): 7327–36. DOI:10.1074/jbc.M006498200. ISSN 0021-9258. PMID 11084024. 
  7. ↑ 7,0 7,1 Beischlag, Timothy V; Wang Song, Rose David W, Torchia Joseph, Reisz-Porszasz Suzanne, Muhammad Khurshid, Nelson Walter E, Probst Markus R, Rosenfeld Michael G, Hankinson Oliver (June 2002). „Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex”. Mol. Cell. Biol. (United States) 22 (12): 4319–33. DOI:10.1128/MCB.22.12.4319-4333.2002. ISSN 0270-7306. PMC 133867. PMID 12024042. 
  8. ↑ 8,0 8,1 8,2 Wan, Kah Fei; Sambi Balwinder S, Tate Rothwelle, Waters Catherine, Pyne Nigel J (May 2003). „The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor”. J. Biol. Chem. (United States) 278 (20): 18658–63. DOI:10.1074/jbc.M212103200. ISSN 0021-9258. PMID 12624098. 
  9. ↑ 9,0 9,1 Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E (June 1999). „ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases”. J. Biol. Chem. (UNITED STATES) 274 (24): 17209–18. DOI:10.1074/jbc.274.24.17209. ISSN 0021-9258. PMID 10358079. 
  10. ↑ Cirri, P; Chiarugi P, Marra F, Raugei G, Camici G, Manao G, Ramponi G (October 1997). „c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells”. Biochem. Biophys. Res. Commun. (UNITED STATES) 239 (2): 493–7. DOI:10.1006/bbrc.1997.7493. ISSN 0006-291X. PMID 9344858. 
  11. ↑ Zisch, A H; Kalo M S, Chong L D, Pasquale E B (May 1998). „Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region”. Oncogene (ENGLAND) 16 (20): 2657–70. DOI:10.1038/sj.onc.1201823. ISSN 0950-9232. PMID 9632142. 
  12. ↑ Zisch, A H; Pazzagli C, Freeman A L, Schneller M, Hadman M, Smith J W, Ruoslahti E, Pasquale E B (January 2000). „Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses”. Oncogene (ENGLAND) 19 (2): 177–87. DOI:10.1038/sj.onc.1203304. ISSN 0950-9232. PMID 10644995. 
  13. ↑ 13,0 13,1 13,2 Migliaccio, A; Castoria G, Di Domenico M, de Falco A, Bilancio A, Lombardi M, Barone M V, Ametrano D, Zannini M S, Abbondanza C, Auricchio F (October 2000). „Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation”. EMBO J. (ENGLAND) 19 (20): 5406–17. DOI:10.1093/emboj/19.20.5406. ISSN 0261-4189. PMC 314017. PMID 11032808. 
  14. ↑ Unni, Emmanual; Sun Shihua, Nan Bicheng, McPhaul Michael J, Cheskis Boris, Mancini Michael A, Marcelli Marco (October 2004). „Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence”. Cancer Res. (United States) 64 (19): 7156–68. DOI:10.1158/0008-5472.CAN-04-1121. ISSN 0008-5472. PMID 15466214. 
  15. ↑ Powell, S M; Christiaens V, Voulgaraki D, Waxman J, Claessens F, Bevan C L (March 2004). „Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate”. Endocr. Relat. Cancer (England) 11 (1): 117–30. DOI:10.1677/erc.0.0110117. ISSN 1351-0088. PMID 15027889. 
  16. ↑ Seibenhener, M L; Roehm J, White W O, Neidigh K B, Vandenplas M L, Wooten M W (July 1999). „Identification of Src as a novel atypical protein kinase C-interacting protein”. Mol. Cell Biol. Res. Commun. (UNITED STATES) 2 (1): 28–31. DOI:10.1006/mcbr.1999.0140. ISSN 1522-4724. PMID 10527887. 
  17. ↑ Cao, X; Tay A, Guy G R, Tan Y H (April 1996). „Activation and association of Stat3 with Src in v-Src-transformed cell lines”. Mol. Cell. Biol. (UNITED STATES) 16 (4): 1595–603. ISSN 0270-7306. PMC 231145. PMID 8657134. 
  18. ↑ Saci, Abdelhafid; Liu Wang-Qing, Vidal Michel, Garbay Christiane, Rendu Francine, Bachelot-Loza Christilla (May 2002). „Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement”. Biochem. J. (England) 363 (Pt 3): 717–25. DOI:10.1042/0264-6021:3630717. ISSN 0264-6021. PMC 1222524. PMID 11964172. 
  19. ↑ Cao, W; Luttrell L M, Medvedev A V, Pierce K L, Daniel K W, Dixon T M, Lefkowitz R J, Collins S (December 2000). „Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation”. J. Biol. Chem. (UNITED STATES) 275 (49): 38131–4. DOI:10.1074/jbc.C000592200. ISSN 0021-9258. PMID 11013230. 
  20. ↑ 20,0 20,1 Keely, S J; Calandrella S O, Barrett K E (April 2000). „Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular ca(2+), PYK-2, and p60(src)”. J. Biol. Chem. (UNITED STATES) 275 (17): 12619–25. DOI:10.1074/jbc.275.17.12619. ISSN 0021-9258. PMID 10777553. 
  21. ↑ Sato, K; Kimoto M, Kakumoto M, Horiuchi D, Iwasaki T, Tokmakov A A, Fukami Y (September 2000). „Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells”. Genes Cells (ENGLAND) 5 (9): 749–64. DOI:10.1046/j.1365-2443.2000.00358.x. ISSN 1356-9597. PMID 10971656. 
  22. ↑ 22,0 22,1 Hsia, Datsun A; Mitra Satyajit K, Hauck Christof R, Streblow Daniel N, Nelson Jay A, Ilic Dusko, Huang Shuang, Li Erguang, Nemerow Glen R, Leng Jay, Spencer Kathryn S R, Cheresh David A, Schlaepfer David D (March 2003). „Differential regulation of cell motility and invasion by FAK”. J. Cell Biol. (United States) 160 (5): 753–67. DOI:10.1083/jcb.200212114. ISSN 0021-9525. PMC 2173366. PMID 12615911. 
  23. ↑ Hecker, Timothy P; Grammer J Robert, Gillespie G Yancey, Stewart Jerry, Gladson Candece L (May 2002). „Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples”. Cancer Res. (United States) 62 (9): 2699–707. ISSN 0008-5472. PMID 11980671. 
  24. ↑ 24,0 24,1 Angers-Loustau, A; Côté J F, Charest A, Dowbenko D, Spencer S, Lasky L A, Tremblay M L (March 1999). „Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts”. J. Cell Biol. (UNITED STATES) 144 (5): 1019–31. DOI:10.1083/jcb.144.5.1019. ISSN 0021-9525. PMC 2148201. PMID 10085298. 
  25. ↑ Relou, Ingrid A M; Bax Liane A B, van Rijn Herman J M, Akkerman Jan-Willem N (January 2003). „Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein”. Biochem. J. (England) 369 (Pt 2): 407–16. DOI:10.1042/BJ20020410. ISSN 0264-6021. PMC 1223094. PMID 12387730. 
  26. ↑ Messina, Samantha; Onofri Franco, Bongiorno-Borbone Lucilla, Giovedì Silvia, Valtorta Flavia, Girault Jean-Antoine, Benfenati Fabio (January 2003). „Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin”. J. Neurochem. (England) 84 (2): 253–65. DOI:10.1046/j.1471-4159.2003.01519.x. ISSN 0022-3042. PMID 12558988. 
  27. ↑ Lebrun, P; Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V (November 1998). „Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)”. J. Biol. Chem. (UNITED STATES) 273 (48): 32244–53. DOI:10.1074/jbc.273.48.32244. ISSN 0021-9258. PMID 9822703. 
  28. ↑ Zhou, Jian; Scholes Jessica, Hsieh Jer-Tsong (February 2003). „Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer”. J. Biol. Chem. (United States) 278 (9): 6936–41. DOI:10.1074/jbc.M210628200. ISSN 0021-9258. PMID 12473651. 
  29. ↑ Maa, M C; Lai J R, Lin R W, Leu T H (July 1999). „Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src”. Biochim. Biophys. Acta (NETHERLANDS) 1450 (3): 341–51. DOI:10.1016/S0167-4889(99)00069-5. ISSN 0006-3002. PMID 10395945. 
  30. ↑ Sotgia, F; Lee H, Bedford M T, Petrucci T, Sudol M, Lisanti M P (December 2001). „Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins”. Biochemistry (United States) 40 (48): 14585–92. DOI:10.1021/bi011247r. ISSN 0006-2960. PMID 11724572. 
  31. ↑ Teo, A K; Oh H K, Ali R B, Li B F (October 2001). „The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage”. Mol. Cell. Biol. (United States) 21 (20): 7105–14. DOI:10.1128/MCB.21.20.7105-7114.2001. ISSN 0270-7306. PMC 99886. PMID 11564893. 
  32. ↑ 32,0 32,1 Kim, H J; Yi J Y, Sung H S, Moore D D, Jhun B H, Lee Y C, Lee J W (September 1999). „Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation”. Mol. Cell. Biol. (UNITED STATES) 19 (9): 6323–32. ISSN 0270-7306. PMC 84603. PMID 10454579. 
  33. ↑ 33,0 33,1 Slentz-Kesler, K; Moore J T, Lombard M, Zhang J, Hollingsworth R, Weiner M P (October 2000). „Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta”. Genomics (UNITED STATES) 69 (1): 63–71. DOI:10.1006/geno.2000.6299. ISSN 0888-7543. PMID 11013076. 
  34. ↑ Soutoglou, E; Papafotiou G, Katrakili N, Talianidis I (April 2000). „Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins”. J. Biol. Chem. (UNITED STATES) 275 (17): 12515–20. DOI:10.1074/jbc.275.17.12515. ISSN 0021-9258. PMID 10777539. 
  35. ↑ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (September 2005). „A human protein-protein interaction network: a resource for annotating the proteome”. Cell (United States) 122 (6): 957–68. DOI:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 
  36. ↑ Oneyama, Chitose; Nakano Hirofumi, Sharma Sreenath V (March 2002). „UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug”. Oncogene (England) 21 (13): 2037–50. DOI:10.1038/sj.onc.1205271. ISSN 0950-9232. PMID 11960376. 
  37. ↑ Koch, C A; Moran M F, Anderson D, Liu X Q, Mbamalu G, Pawson T (March 1992). „Multiple SH2-mediated interactions in v-src-transformed cells”. Mol. Cell. Biol. (UNITED STATES) 12 (3): 1366–74. ISSN 0270-7306. PMC 369570. PMID 1545818. 
  38. ↑ Shen, Z; Batzer A, Koehler J A, Polakis P, Schlessinger J, Lydon N B, Moran M F (August 1999). „Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src”. Oncogene (ENGLAND) 18 (33): 4647–53. DOI:10.1038/sj.onc.1203079. ISSN 0950-9232. PMID 10467411. 
  39. ↑ Finan, P M; Hall A, Kellie S (July 1996). „Sam68 from an immortalised B-cell line associates with a subset of SH3 domains”. FEBS Lett. (NETHERLANDS) 389 (2): 141–4. DOI:10.1016/0014-5793(96)00552-2. ISSN 0014-5793. PMID 8766817. 
  40. ↑ Brown, M T; Andrade J, Radhakrishna H, Donaldson J G, Cooper J A, Randazzo P A (December 1998). „ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src”. Mol. Cell. Biol. (UNITED STATES) 18 (12): 7038–51. ISSN 0270-7306. PMC 109286. PMID 9819391. 
  41. ↑ Li, Y; Kuwahara H, Ren J, Wen G, Kufe D (March 2001). „The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin”. J. Biol. Chem. (United States) 276 (9): 6061–4. DOI:10.1074/jbc.C000754200. ISSN 0021-9258. PMID 11152665. 
  42. ↑ Li, Y; Ren J, Yu W, Li Q, Kuwahara H, Yin L, Carraway K L, Kufe D (September 2001). „The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin”. J. Biol. Chem. (United States) 276 (38): 35239–42. DOI:10.1074/jbc.C100359200. ISSN 0021-9258. PMID 11483589. 
  43. ↑ Kumar, S; Avraham S, Bharti A, Goyal J, Pandey P, Kharbanda S (October 1999). „Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1”. J. Biol. Chem. (UNITED STATES) 274 (43): 30657–63. DOI:10.1074/jbc.274.43.30657. ISSN 0021-9258. PMID 10521452. 
  44. ↑ Dikic, I; Tokiwa G, Lev S, Courtneidge S A, Schlessinger J (October 1996). „A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation”. Nature (ENGLAND) 383 (6600): 547–50. DOI:10.1038/383547a0. ISSN 0028-0836. PMID 8849729. 
  45. ↑ Burnham, M R; Harte M T, Bouton A H (September 1999). „The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation”. Mol. Carcinog. (UNITED STATES) 26 (1): 20–31. DOI:10.1002/(SICI)1098-2744(199909)26:1<20::AID-MC3>3.0.CO;2-M. ISSN 0899-1987. PMID 10487518. 
  46. ↑ Wei, Lin; Yang Yu, Zhang Xin, Yu Qiang (2002). „Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoikis”. J. Cell. Biochem. (United States) 87 (4): 439–49. DOI:10.1002/jcb.10322. ISSN 0730-2312. PMID 12397603. 
  47. ↑ Kovacic-Milivojević, B; Roediger F, Almeida E A, Damsky C H, Gardner D G, Ilić D (August 2001). „Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy”. Mol. Biol. Cell (United States) 12 (8): 2290–307. ISSN 1059-1524. PMC 58595. PMID 11514617. 
  48. ↑ Donaldson, J C; Dempsey P J, Reddy S, Bouton A H, Coffey R J, Hanks S K (April 2000). „Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells”. Exp. Cell Res. (UNITED STATES) 256 (1): 168–78. DOI:10.1006/excr.2000.4822. ISSN 0014-4827. PMID 10739664. 
  49. ↑ Karlsson, T; Songyang Z, Landgren E, Lavergne C, Di Fiore P P, Anafi M, Pawson T, Cantley L C, Claesson-Welsh L, Welsh M (April 1995). „Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins”. Oncogene (ENGLAND) 10 (8): 1475–83. ISSN 0950-9232. PMID 7537362. 
  50. ↑ Ahn, Bong-Hyun; Kim Shi Yeon, Kim Eun Hee, Choi Kyeong Sook, Kwon Taeg Kyu, Lee Young Han, Chang Jong-Soo, Kim Myung-Suk, Jo Yang-Hyeok, Min Do Sik (May 2003). „Transmodulation between phospholipase D and c-Src enhances cell proliferation”. Mol. Cell. Biol. (United States) 23 (9): 3103–15. DOI:10.1128/MCB.23.9.3103-3115.2003. ISSN 0270-7306. PMC 153190. PMID 12697812. 
  51. ↑ Kim, H J; Kim J H, Lee J W (October 1998). „Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations”. J. Biol. Chem. (UNITED STATES) 273 (44): 28564–7. DOI:10.1074/jbc.273.44.28564. ISSN 0021-9258. PMID 9786846. 
  52. ↑ Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (January 2003). „Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins”. Mol. Cell. Biol. (United States) 23 (1): 140–9. DOI:10.1128/MCB.23.1.140-149.2003. ISSN 0270-7306. PMC 140670. PMID 12482968. 
  53. ↑ Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (November 1999). „A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo”. J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. DOI:10.1074/jbc.274.48.34283. ISSN 0021-9258. PMID 10567404. 
  54. ↑ Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (June 2000). „Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2”. Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. DOI:10.1210/me.14.6.915. ISSN 0888-8809. PMID 10847592. 
  55. ↑ Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (February 2001). „Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2”. Mol. Endocrinol. (United States) 15 (2): 241–54. DOI:10.1210/me.15.2.241. ISSN 0888-8809. PMID 11158331. 
  56. ↑ He, Bin; Wilson Elizabeth M (March 2003). „Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Mol. Cell. Biol. (United States) 23 (6): 2135–50. DOI:10.1128/MCB.23.6.2135-2150.2003. ISSN 0270-7306. PMC 149467. PMID 12612084. 
  57. ↑ Banin, S; Truong O, Katz D R, Waterfield M D, Brickell P M, Gout I (August 1996). „Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases”. Curr. Biol. (ENGLAND) 6 (8): 981–8. DOI:10.1016/S0960-9822(02)00642-5. ISSN 0960-9822. PMID 8805332. 
  58. ↑ Finan, P M; Soames C J, Wilson L, Nelson D L, Stewart D M, Truong O, Hsuan J J, Kellie S (October 1996). „Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains”. J. Biol. Chem. (UNITED STATES) 271 (42): 26291–5. DOI:10.1074/jbc.271.42.26291. ISSN 0021-9258. PMID 8824280. 
  59. ↑ Moon, Sun Young; Zang Heesuk, Zheng Yi (February 2003). „Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP”. J. Biol. Chem. (United States) 278 (6): 4151–9. DOI:10.1074/jbc.M207789200. ISSN 0021-9258. PMID 12454018. 
  60. ↑ Brott, B K; Decker S, O'Brien M C, Jove R (October 1991). „Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein”. Mol. Cell. Biol. (UNITED STATES) 11 (10): 5059–67. ISSN 0270-7306. PMC 361505. PMID 1717825. 
  61. ↑ Giglione, C; Gonfloni S, Parmeggiani A (June 2001). „Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm”. Eur. J. Biochem. (Germany) 268 (11): 3275–83. DOI:10.1046/j.1432-1327.2001.02230.x. ISSN 0014-2956. PMID 11389730. 
  62. ↑ Gingrich, Jeffrey R; Pelkey Kenneth A, Fam Sami R, Huang Yueqiao, Petralia Ronald S, Wenthold Robert J, Salter Michael W (April 2004). „Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2”. Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (16): 6237–42. DOI:10.1073/pnas.0401413101. ISSN 0027-8424. PMC 395953. PMID 15069201. 
  63. ↑ Chang, B Y; Conroy K B, Machleder E M, Cartwright C A (June 1998). „RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells”. Mol. Cell. Biol. (UNITED STATES) 18 (6): 3245–56. ISSN 0270-7306. PMC 108906. PMID 9584165. 

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