FLT1

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Tirozinska kinasa 1 srodna sa Fms

PDB prikaz baziran na 1flt.
Dostupne strukture
1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG
Identifikatori
SimboliFLT1; FLT; FLT-1; VEGFR-1; VEGFR1
Vanjski IDOMIM165070 MGI95558 HomoloGene134179 GeneCards: FLT1 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE FLT1 222033 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez232114254
EnsemblENSG00000102755ENSMUSG00000029648
UniProtP17948P35969
Ref. Sekv. (iRNK)NM_001159920NM_010228
Ref. Sekv. (protein)NP_001153392NP_034358
Lokacija (UCSC)Chr 13:
28.87 - 29.07 Mb
Chr 5:
147.56 - 147.73 Mb
PubMed pretraga[1][2]

Receptor 1 vaskularnog endotelnog faktora rasta je protein koji je kod ljudi kodiran FLT1 genom.[1]

Onkogen FLT pripada src genskoj familiji i srodan je onkogenu ROS (MIM 165020). Poput drugih članova ove familije, on no je tirozinska proteinska kinaza koja učestvuje u kontroli ćelijske proliferacije i diferencije. Sekvenca FLT gena podseća na FMS gen (MIM 164770) i stoga su Yoshida et al. (1987) predložili ime FLT kao akronim za FMS-sličnu tirozinsku kinazu.[[2]

Interakcije[uredi - уреди | uredi izvor]

FLT1 formira interakscije sa PLCG1[3] i vaskularnim endotelnim faktorom rasta.[4][5]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (May 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene 5 (4): 519–24. PMID 2158038. 
  2. "Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2321. 
  3. Cunningham, S A; Arrate M P; Brock T A; Waxham M N (Nov 1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochem. Biophys. Res. Commun. (UNITED STATES) 240 (3): 635–9. ISSN 0006-291X. PMID 9398617. doi:10.1006/bbrc.1997.7719.  Check date values in: |date= (help)
  4. Olofsson, B; Korpelainen E, Pepper M S, Mandriota S J, Aase K, Kumar V, Gunji Y, Jeltsch M M, Shibuya M, Alitalo K, Eriksson U (Sep 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (20): 11709–14. ISSN 0027-8424. PMC 21705. PMID 9751730. doi:10.1073/pnas.95.20.11709.  Check date values in: |date= (help)
  5. Makinen, T; Olofsson B; Karpanen T; Hellman U; Soker S; Klagsbrun M; Eriksson U; Alitalo K (Jul 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. (UNITED STATES) 274 (30): 21217–22. ISSN 0021-9258. PMID 10409677. doi:10.1074/jbc.274.30.21217.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]