TYRO3

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TYRO3 proteinska tirozinska kinaza

PDB prikaz baziran na 1rhf.
Dostupne strukture
1RHF
Identifikatori
SimboliTYRO3; BYK; Dtk; RSE; Sky; Tif
Vanjski IDOMIM600341 MGI104294 HomoloGene4585 GeneCards: TYRO3 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE TYRO3 211432 s at tn.png
PBB GE TYRO3 211431 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez730122174
EnsemblENSG00000092445ENSMUSG00000027298
UniProtQ06418P55144
Ref. Sekv. (iRNK)NM_006293NM_001290800
Ref. Sekv. (protein)NP_006284NP_001277729
Lokacija (UCSC)Chr 15:
41.85 - 41.87 Mb
Chr 2:
119.8 - 119.82 Mb
PubMed pretraga[1][2]

Tirozinski proteinsko kinazni receptor TYRO3 je enzim koji je kod ljudi kodiran TYRO3 genom.[1][2]

Interakcije[uredi - уреди | uredi izvor]

TYRO3 formira interakcije sa PIK3R1[3] i GAS6.[4][5]

Reference[uredi - уреди | uredi izvor]

  1. Richard I; Broux O; Chiannilkulchai N; Fougerousse F; Allamand V; Bourg N; Brenguier L; Devaud C; Pasturaud P (March 1995). "Regional localization of human chromosome 15 loci". Genomics 23 (3): 619–27. PMID 7851890. doi:10.1006/geno.1994.1550. 
  2. "Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7301. 
  3. Lan, Z; Wu H; Li W; Wu S; Lu L; Xu M; Dai W (January 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood (UNITED STATES) 95 (2): 633–8. ISSN 0006-4971. PMID 10627473. 
  4. Mark, M R; Chen J; Hammonds R G; Sadick M; Godowsk P J (April 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. (UNITED STATES) 271 (16): 9785–9. ISSN 0021-9258. PMID 8621659. doi:10.1074/jbc.271.16.9785. 
  5. Nagata, K; Ohashi K; Nakano T; Arita H; Zong C; Hanafusa H; Mizuno K (November 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 30022–7. ISSN 0021-9258. PMID 8939948. doi:10.1074/jbc.271.47.30022. 

Literatura[uredi - уреди | uredi izvor]

  • Mark MR; Scadden DT; Wang Z et al. (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain". J. Biol. Chem. 269 (14): 10720–8. PMID 7511603. 
  • Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. PMID 7537495. doi:10.1006/bbrc.1995.1549. 
  • Crosier KE; Hall LR; Lewis PM et al. (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors 11 (2): 137–44. PMID 7857658. doi:10.3109/08977199409001055. 
  • Ohashi K; Mizuno K; Kuma K et al. (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". Oncogene 9 (3): 699–705. PMID 8108112. 
  • Dai W; Pan H; Hassanain H et al. (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". Oncogene 9 (3): 975–9. PMID 8108143. 
  • Polvi A; Armstrong E; Lai C et al. (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". Gene 134 (2): 289–93. PMID 8262388. doi:10.1016/0378-1119(93)90109-G. 
  • Mark MR; Chen J; Hammonds RG et al. (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. PMID 8621659. doi:10.1074/jbc.271.16.9785. 
  • Crosier PS; Freeman SA; Orlic D et al. (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". Exp. Hematol. 24 (2): 318–23. PMID 8641360. 
  • Nagata K; Ohashi K; Nakano T et al. (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. PMID 8939948. doi:10.1074/jbc.271.47.30022. 
  • Kajii Y; Ninomiya D; Kato M et al. (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". Biol. Cell 88 (1–2): 45–54. PMID 9175267. doi:10.1016/S0248-4900(97)86830-X. 
  • Lan Z; Wu H; Li W et al. (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood 95 (2): 633–8. PMID 10627473. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Yin JL; Hambly BD; Bao SS et al. (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transpl. Int. 16 (9): 681–8. PMID 12768229. doi:10.1007/s00147-003-0593-3. 
  • Heiring C, Dahlbäck B, Muller YA (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family". J. Biol. Chem. 279 (8): 6952–8. PMID 14623883. doi:10.1074/jbc.M311750200. 
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 
  • Gould WR; Baxi SM; Schroeder R et al. (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". J. Thromb. Haemost. 3 (4): 733–41. PMID 15733062. doi:10.1111/j.1538-7836.2005.01186.x. 
  • Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. PMID 15964779. doi:10.1016/j.biocel.2005.05.006. 
  • Shimojima M; Takada A; Ebihara H et al. (2006). "Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses". J. Virol. 80 (20): 10109–16. PMC 1617303. PMID 17005688. doi:10.1128/JVI.01157-06.