EPHB6
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| edit |
| EPH receptor B6 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | EPHB6; HEP | ||||||||||
| Vanjski ID | OMIM: 602757 MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2051 | 13848 | |||||||||
| Ensembl | ENSG00000106123 | ENSMUSG00000029869 | |||||||||
| UniProt | O15197 | O08644 | |||||||||
| Ref. Sekv. (iRNK) | NM_001280794 | NM_001146351 | |||||||||
| Ref. Sekv. (protein) | NP_001267723 | NP_001139823 | |||||||||
| Lokacija (UCSC) | Chr 7: 142.55 - 142.57 Mb | Chr 6: 41.61 - 41.62 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor 6 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB6 genom.[1]
Efrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.[1]
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). „The Eph family receptors and ligands”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis”. Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly”. Int. Rev. Cytol.. International Review of Cytology 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
- Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076.
- Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
- Matsuoka H, Iwata N, Ito M, et al. (1997). „Expression of a kinase-defective Eph-like receptor in the normal human brain”. Biochem. Biophys. Res. Commun. 235 (3): 487–92. DOI:10.1006/bbrc.1997.6812. PMID 9207182.
- Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020.
- Hock B, Böhme B, Karn T, et al. (1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
- Munthe E, Rian E, Holien T, et al. (2000). „Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6”. FEBS Lett. 466 (1): 169–74. DOI:10.1016/S0014-5793(99)01793-7. PMID 10648835.
- Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). „T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells”. Growth Factors 18 (1): 63–78. DOI:10.3109/08977190009003234. PMID 10831073.
- Tang XX, Zhao H, Robinson ME, et al. (2000). „Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma”. Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936–41. DOI:10.1073/pnas.190123297. PMC 27127. PMID 10984508.
- Luo H, Wan X, Wu Y, Wu J (2001). „Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells”. J. Immunol. 167 (3): 1362–70. DOI:10.4049/jimmunol.167.3.1362. PMID 11466354.