YES1
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| YES proto-onkogen 1, Src familija tirozinskih kinaza | |||||||||||
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 PDB prikaz baziran na 2hda. | |||||||||||
| Dostupne strukture | |||||||||||
| 2HDA | |||||||||||
| Identifikatori | |||||||||||
| Simboli | YES1; HsT441; P61-YES; Yes; c-yes | ||||||||||
| Vanjski ID | OMIM: 164880 MGI: 99147 HomoloGene: 55900 GeneCards: YES1 Gene | ||||||||||
| EC broj | 2.7.10.2 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 7525 | 22612 | |||||||||
| Ensembl | ENSG00000176105 | ENSMUSG00000014932 | |||||||||
| UniProt | P07947 | Q04736 | |||||||||
| Ref. Sekv. (iRNK) | NM_005433 | NM_001205132 | |||||||||
| Ref. Sekv. (protein) | NP_005424 | NP_001192061 | |||||||||
| Lokacija (UCSC) | Chr 18: 0.72 - 0.81 Mb | Chr 5: 32.61 - 32.69 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Proto-onkogenska tirozinska proteinska kinaza Yes je enzim koji je kod ljudi kodiran YES1 genom.[1][2]
Ovaj gen je ćelijski homolog Yamaguchi sarkoma virusnog onkogena. Kodirani protein deluje kao tirozinska kinaza i pripada src familiji proteina. Gen je lociran u blizini gena timidilatne sintaze na hromozomu 18, a korespondirajući pseudogen je prisutan na hromozomu 22.[2]
Interakcije[uredi | uredi kod]
YES1 formira interakcije sa Janus kinazom 2,[3] CTNND1,[4] RPL10[5] i Occludin.[6]
Reference[uredi | uredi kod]
- ↑ Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). „Location of the c-yes gene on the human chromosome and its expression in various tissues”. Science 227 (4690): 1038–40. DOI:10.1126/science.2983418. PMID 2983418.
- ↑ 2,0 2,1 „Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1”.
- ↑ Fuhrer, D K; Yang Y C (Jul 1996). „Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11”. Biochem. Biophys. Res. Commun. (UNITED STATES) 224 (2): 289–96. DOI:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385.
- ↑ Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). „p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction”. Mol. Cell. Biol. (United States) 23 (7): 2287–97. DOI:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114.
- ↑ Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). „QM, a putative tumor suppressor, regulates proto-oncogene c-yes”. J. Biol. Chem. (United States) 277 (39): 36489–98. DOI:10.1074/jbc.M201859200. ISSN 0021-9258. PMID 12138090.
- ↑ Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). „Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells”. Mol. Biol. Cell (United States) 13 (4): 1227–37. DOI:10.1091/mbc.01-08-0423. ISSN 1059-1524. PMC 102264. PMID 11950934.
Literatura[uredi | uredi kod]
- Brickell PM (1992). „The p60c-src family of protein-tyrosine kinases: structure, regulation, and function.”. Critical reviews in oncogenesis 3 (4): 401–46. PMID 1384720.
- Toyoshima K, Semba K, Nishizawa M, et al. (1988). „Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family.”. Int. Symp. Princess Takamatsu Cancer Res. Fund 17: 11–20. PMID 3332005.
- Sudol M, Chen HI, Bougeret C, et al. (1995). „Characterization of a novel protein-binding module--the WW domain.”. FEBS Lett. 369 (1): 67–71. DOI:10.1016/0014-5793(95)00550-S. PMID 7641887.
- Summy JM, Sudol M, Eck MJ, et al. (2004). „Specificity in signaling by c-Yes.”. Front. Biosci. 8: s185–205. DOI:10.2741/1011. PMID 12456296.
- Cichowski K, McCormick F, Brugge JS (1992). „p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets.”. J. Biol. Chem. 267 (8): 5025–8. PMID 1544885.
- Huang MM, Bolen JB, Barnwell JW, et al. (1991). „Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.”. Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7844–8. DOI:10.1073/pnas.88.17.7844. PMC 52400. PMID 1715582.
- Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H (1992). „Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.”. Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10411–5. DOI:10.1073/pnas.88.23.10411. PMC 52938. PMID 1720539.
- Krueger J, Zhao YH, Murphy D, Sudol M (1991). „Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis.”. Oncogene 6 (6): 933–40. PMID 2067846.
- Zhao YH, Krueger JG, Sudol M (1991). „Expression of cellular-yes protein in mammalian tissues.”. Oncogene 5 (11): 1629–35. PMID 2267131.
- Sukegawa J, Semba K, Yamanashi Y, et al. (1987). „Characterization of cDNA clones for the human c-yes gene.”. Mol. Cell. Biol. 7 (1): 41–7. PMC 365039. PMID 2436037.
- Bull HA, Brickell PM, Dowd PM (1994). „Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells.”. FEBS Lett. 351 (1): 41–4. DOI:10.1016/0014-5793(94)00814-0. PMID 7521304.
- Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). „Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.”. Biochem. Biophys. Res. Commun. 209 (2): 656–63. DOI:10.1006/bbrc.1995.1549. PMID 7537495.
- Courtneidge SA, Dhand R, Pilat D, et al. (1993). „Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.”. EMBO J. 12 (3): 943–50. PMC 413295. PMID 7681396.
- Mori S, Rönnstrand L, Yokote K, et al. (1993). „Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.”. EMBO J. 12 (6): 2257–64. PMC 413454. PMID 7685273.
- Waltenberger J, Claesson-Welsh L, Siegbahn A, et al. (1994). „Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.”. J. Biol. Chem. 269 (43): 26988–95. PMID 7929439.
- Silverman GA, Kuo WL, Taillon-Miller P, Gray JW (1993). „Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18.”. Genomics 15 (2): 442–5. DOI:10.1006/geno.1993.1086. PMID 8449516.
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