YES1

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YES proto-onkogen 1, Src familija tirozinskih kinaza

PDB prikaz baziran na 2hda.
Dostupne strukture
2HDA
Identifikatori
SimboliYES1; HsT441; P61-YES; Yes; c-yes
Vanjski IDOMIM164880 MGI99147 HomoloGene55900 GeneCards: YES1 Gene
EC broj2.7.10.2
Pregled RNK izražavanja
PBB GE YES1 202933 s at tn.png
PBB GE YES1 202932 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez752522612
EnsemblENSG00000176105ENSMUSG00000014932
UniProtP07947Q04736
Ref. Sekv. (iRNK)NM_005433NM_001205132
Ref. Sekv. (protein)NP_005424NP_001192061
Lokacija (UCSC)Chr 18:
0.72 - 0.81 Mb
Chr 5:
32.61 - 32.69 Mb
PubMed pretraga[1][2]

Proto-onkogenska tirozinska proteinska kinaza Yes je enzim koji je kod ljudi kodiran YES1 genom.[1][2]

Ovaj gen je ćelijski homolog Yamaguchi sarkoma virusnog onkogena. Kodirani protein deluje kao tirozinska kinaza i pripada src familiji proteina. Gen je lociran u blizini gena timidilatne sintaze na hromozomu 18, a korespondirajući pseudogen je prisutan na hromozomu 22.[2]

Interakcije[uredi - уреди | uredi izvor]

YES1 formira interakcije sa Janus kinazom 2,[3] CTNND1,[4] RPL10[5] i Occludin.[6]

Reference[uredi - уреди | uredi izvor]

  1. Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science 227 (4690): 1038–40. PMID 2983418. doi:10.1126/science.2983418.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7525. 
  3. Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. (UNITED STATES) 224 (2): 289–96. ISSN 0006-291X. PMID 8702385. doi:10.1006/bbrc.1996.1023.  Check date values in: |date= (help)
  4. Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. (United States) 23 (7): 2287–97. ISSN 0270-7306. PMC 150740. PMID 12640114. doi:10.1128/MCB.23.7.2287-2297.2003.  Check date values in: |date= (help)
  5. Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. (United States) 277 (39): 36489–98. ISSN 0021-9258. PMID 12138090. doi:10.1074/jbc.M201859200.  Check date values in: |date= (help)
  6. Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell (United States) 13 (4): 1227–37. ISSN 1059-1524. PMC 102264. PMID 11950934. doi:10.1091/mbc.01-08-0423.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]