Anaplastična limfomna kinaza

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Anaplastična limfomna receptorska tirozinska kinaza

Ljudska anaplastična limfomna kinaza u kompleksu sa krizotinibom. PDB 2xp2[1]
Dostupne strukture
2KUP, 2KUQ, 2XB7, 2XBA, 2XP2, 2YFX, 2YHV, 2YJR, 2YJS, 2YS5, 2YT2, 3AOX, 3L9P, 3LCS, 3LCT, 4ANL, 4ANQ, 4ANS, 4CCB, 4CCU, 4CD0, 4DCE, 4FNW, 4FNX, 4FNY, 4FNZ, 4FOB, 4FOC, 4FOD, 4JOA, 4MKC
Identifikatori
SimboliALK; CD246; NBLST3
Vanjski IDOMIM105590 MGI103305 HomoloGene68387 GeneCards: ALK Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE ALK 208211 s at tn.png
PBB GE ALK 208212 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez23811682
EnsemblENSG00000171094ENSMUSG00000055471
UniProtQ9UM73P97793
Ref. Sekv. (iRNK)NM_004304NM_007439
Ref. Sekv. (protein)NP_004295NP_031465
Lokacija (UCSC)Chr 2:
29.42 - 30.14 Mb
Chr 17:
71.87 - 72.6 Mb
PubMed pretraga[1][2]

Anaplastična limfomna kinaza (ALK, ALK tirozinski kinazni receptor, CD246, klaster diferencijacije 246) enzim je koji je kod ljudi kodiran ALK genom.[2][3]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Cui JJ, Tran-Dubé M, Shen H, Nambu M, Kung PP, Pairish M, Jia L, Meng J, Funk L, Botrous I, McTigue M, Grodsky N, Ryan K, Padrique E, Alton G, Timofeevski S, Yamazaki S, Li Q, Zou H, Christensen J, Mroczkowski B, Bender S, Kania RS, Edwards MP (September 2011). "Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)". J. Med. Chem. 54 (18): 6342–63. PMID 21812414. doi:10.1021/jm2007613. 
  2. Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (Apr 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science 263 (5151): 1281–4. PMID 8122112. doi:10.1126/science.8122112.  Check date values in: |date= (help)
  3. "Entrez Gene: ALK anaplastic lymphoma kinase (Ki-1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=238. 

Literatura[uredi - уреди | uredi izvor]

Vanjske veze[uredi - уреди | uredi izvor]