ERBB4
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| V-erb-b2 ptičiji eritroblastni leukemijski viralni onkogeni homolog 4 | |||||||||||
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 PDB prolaz baziran na 2ahx. | |||||||||||
| Dostupne strukture | |||||||||||
| 2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U | |||||||||||
| Identifikatori | |||||||||||
| Simboli | ERBB4; ALS19; HER4; p180erbB4 | ||||||||||
| Vanjski ID | OMIM: 600543 MGI: 104771 HomoloGene: 21084 GeneCards: ERBB4 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2066 | 13869 | |||||||||
| Ensembl | ENSG00000178568 | ENSMUSG00000062209 | |||||||||
| UniProt | Q15303 | Q61527 | |||||||||
| Ref. Sekv. (iRNK) | NM_001042599 | NM_010154 | |||||||||
| Ref. Sekv. (protein) | NP_001036064 | NP_034284 | |||||||||
| Lokacija (UCSC) | Chr 2: 212.24 - 213.4 Mb | Chr 1: 68.03 - 69.11 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptorska tirozinska proteinska kinaza erbB-4 je enzim koji je kod ljudi kodiran ERBB4 genom.[1][2] Alternativno splajsovane varijante koje kodiraju različite proteinske izoforme su poznate; mada sve nisu izučene.[3]
Interakcije[uredi - уреди | uredi izvor]
ERBB4 formira interakcije sa:
Reference[uredi - уреди | uredi izvor]
- ↑ Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (May 1995). "Localization of the human HER4/erbB-4 gene to chromosome 2". Oncogene 10 (6): 1235–7. PMID 7700649.
- ↑ Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (October 2006). "Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain". Cell 127 (1): 185–97. PMID 17018285. doi:10.1016/j.cell.2006.07.037.
- ↑ "Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2066.
- ↑ Garcia, R A; Vasudevan K; Buonanno A (March 2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3596–601. ISSN 0027-8424. PMC 16285. PMID 10725395. doi:10.1073/pnas.070042497.
- ↑ Huang, Y Z; Won S, Ali D W, Wang Q, Tanowitz M, Du Q S, Pelkey K A, Yang D J, Xiong W C, Salter M W, Mei L (May 2000). "Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses". Neuron (UNITED STATES) 26 (2): 443–55. ISSN 0896-6273. PMID 10839362. doi:10.1016/S0896-6273(00)81176-9.
- ↑ Williams, Christopher C; Allison June G; Vidal Gregory A; Burow Matthew E; Beckman Barbara S; Marrero Luis; Jones Frank E (November 2004). "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone". J. Cell Biol. (United States) 167 (3): 469–78. ISSN 0021-9525. PMC 2172499. PMID 15534001. doi:10.1083/jcb.200403155.
- ↑ Schulze, Waltraud X; Deng Lei; Mann Matthias (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. (England) 1 (1): 2005.0008. PMC 1681463. PMID 16729043. doi:10.1038/msb4100012.
- ↑ Omerovic, Jasminka; Puggioni Eleonora M R; Napoletano Silvia; Visco Vincenzo; Fraioli Rocco; Frati Luigi; Gulino Alberto; Alimandi Maurizio (April 2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level". Exp. Cell Res. (United States) 294 (2): 469–79. ISSN 0014-4827. PMID 15023535. doi:10.1016/j.yexcr.2003.12.002.
Literatura[uredi - уреди | uredi izvor]
- Carpenter G (2003). "ErbB-4: mechanism of action and biology". Exp. Cell Res. 284 (1): 66–77. PMID 12648466. doi:10.1016/S0014-4827(02)00100-3.
- Culouscou JM; Plowman GD; Carlton GW et al. (1993). "Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor". J. Biol. Chem. 268 (25): 18407–10. PMID 7689552.
- Barbacci EG; Guarino BC; Stroh JG et al. (1995). "The structural basis for the specificity of epidermal growth factor and heregulin binding". J. Biol. Chem. 270 (16): 9585–9. PMID 7721889. doi:10.1074/jbc.270.16.9585.
- Nagata K; Kohda D; Hatanaka H et al. (1994). "Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4". EMBO J. 13 (15): 3517–23. PMC 395255. PMID 8062828.
- Plowman GD; Culouscou JM; Whitney GS et al. (1993). "Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family". Proc. Natl. Acad. Sci. U.S.A. 90 (5): 1746–50. PMC 45956. PMID 8383326. doi:10.1073/pnas.90.5.1746.
- Cohen BD, Green JM, Foy L, Fell HP (1996). "HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers". J. Biol. Chem. 271 (9): 4813–8. PMID 8617750. doi:10.1074/jbc.271.9.4813.
- Andersson B; Wentland MA; Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.
- Yu W; Andersson B; Worley KC et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. PMC 139146. PMID 9110174. doi:10.1101/gr.7.4.353.
- Elenius K; Paul S; Allison G et al. (1997). "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation". EMBO J. 16 (6): 1268–78. PMC 1169725. PMID 9135143. doi:10.1093/emboj/16.6.1268.
- Chang H; Riese DJ; Gilbert W et al. (1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature 387 (6632): 509–12. PMID 9168114. doi:10.1038/387509a0.
- Carraway KL; Weber JL; Unger MJ et al. (1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature 387 (6632): 512–6. PMID 9168115. doi:10.1038/387512a0.
- Chow NH; Liu HS; Yang HB et al. (1997). "Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma. An immunohistochemical study". Virchows Arch. 430 (6): 461–6. PMID 9230911. doi:10.1007/s004280050056.
- Zhang D; Sliwkowski MX; Mark M et al. (1997). "Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. PMC 23218. PMID 9275162. doi:10.1073/pnas.94.18.9562.
- Elenius K; Corfas G; Paul S et al. (1997). "A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester". J. Biol. Chem. 272 (42): 26761–8. PMID 9334263. doi:10.1074/jbc.272.42.26761.
- Komurasaki T, Toyoda H, Uchida D, Morimoto S (1998). "Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4". Oncogene 15 (23): 2841–8. PMID 9419975. doi:10.1038/sj.onc.1201458.
- Fiddes RJ; Campbell DH; Janes PW et al. (1998). "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3". J. Biol. Chem. 273 (13): 7717–24. PMID 9516479. doi:10.1074/jbc.273.13.7717.
- Jones JT; Ballinger MD; Pisacane PI et al. (1998). "Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis". J. Biol. Chem. 273 (19): 11667–74. PMID 9565587. doi:10.1074/jbc.273.19.11667.
- Srinivasan R, Poulsom R, Hurst HC, Gullick WJ (1998). "Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types". J. Pathol. 185 (3): 236–45. PMID 9771476. doi:10.1002/(SICI)1096-9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7.
- Harari D; Tzahar E; Romano J et al. (1999). "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene 18 (17): 2681–9. PMID 10348342. doi:10.1038/sj.onc.1202631.
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