ERBB4

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V-erb-b2 ptičiji eritroblastni leukemijski viralni onkogeni homolog 4

PDB prolaz baziran na 2ahx.
Dostupne strukture
2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U
Identifikatori
SimboliERBB4; ALS19; HER4; p180erbB4
Vanjski IDOMIM600543 MGI104771 HomoloGene21084 GeneCards: ERBB4 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE ERBB4 206794 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez206613869
EnsemblENSG00000178568ENSMUSG00000062209
UniProtQ15303Q61527
Ref. Sekv. (iRNK)NM_001042599NM_010154
Ref. Sekv. (protein)NP_001036064NP_034284
Lokacija (UCSC)Chr 2:
212.24 - 213.4 Mb
Chr 1:
68.03 - 69.11 Mb
PubMed pretraga[1][2]

Receptorska tirozinska proteinska kinaza erbB-4 je enzim koji je kod ljudi kodiran ERBB4 genom.[1][2] Alternativno splajsovane varijante koje kodiraju različite proteinske izoforme su poznate; mada sve nisu izučene.[3]

Interakcije[uredi - уреди | uredi izvor]

ERBB4 formira interakcije sa:

Reference[uredi - уреди | uredi izvor]

  1. Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (May 1995). "Localization of the human HER4/erbB-4 gene to chromosome 2". Oncogene 10 (6): 1235–7. PMID 7700649. 
  2. Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (October 2006). "Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain". Cell 127 (1): 185–97. PMID 17018285. doi:10.1016/j.cell.2006.07.037. 
  3. "Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2066. 
  4. Garcia, R A; Vasudevan K; Buonanno A (March 2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3596–601. ISSN 0027-8424. PMC 16285. PMID 10725395. doi:10.1073/pnas.070042497. 
  5. Huang, Y Z; Won S, Ali D W, Wang Q, Tanowitz M, Du Q S, Pelkey K A, Yang D J, Xiong W C, Salter M W, Mei L (May 2000). "Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses". Neuron (UNITED STATES) 26 (2): 443–55. ISSN 0896-6273. PMID 10839362. doi:10.1016/S0896-6273(00)81176-9. 
  6. Williams, Christopher C; Allison June G; Vidal Gregory A; Burow Matthew E; Beckman Barbara S; Marrero Luis; Jones Frank E (November 2004). "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone". J. Cell Biol. (United States) 167 (3): 469–78. ISSN 0021-9525. PMC 2172499. PMID 15534001. doi:10.1083/jcb.200403155. 
  7. Schulze, Waltraud X; Deng Lei; Mann Matthias (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. (England) 1 (1): 2005.0008. PMC 1681463. PMID 16729043. doi:10.1038/msb4100012. 
  8. Omerovic, Jasminka; Puggioni Eleonora M R; Napoletano Silvia; Visco Vincenzo; Fraioli Rocco; Frati Luigi; Gulino Alberto; Alimandi Maurizio (April 2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level". Exp. Cell Res. (United States) 294 (2): 469–79. ISSN 0014-4827. PMID 15023535. doi:10.1016/j.yexcr.2003.12.002. 

Literatura[uredi - уреди | uredi izvor]