ERBB3

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V-erb-b2 ptičiji eritroblastni leukemijski viralni onkogeni homolog 3

PDB prikaz baziran na 1m6b.
Dostupne strukture
1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59
Identifikatori
SimboliERBB3; ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3
Vanjski IDOMIM190151 MGI95411 HomoloGene20457 GeneCards: ERBB3 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE ERBB3 202454 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez206513867
EnsemblENSG00000065361ENSMUSG00000018166
UniProtP21860Q61526
Ref. Sekv. (iRNK)NM_001005915NM_010153
Ref. Sekv. (protein)NP_001005915NP_034283
Lokacija (UCSC)Chr 12:
56.47 - 56.5 Mb
Chr 10:
128.57 - 128.59 Mb
PubMed pretraga[1][2]

Receptorska tirozinska proteinska kinaza erbB-3 (HER3, receptor 3 ljudskog epidermalnog faktora rasta) membranski je protein koji je kod ljudi kodiran ERBB3 genom. ErbB3 je član familjie receptora epidermalnog faktora rasta (EGFR/ERBB) koji su receptorske tirozinske kinaze.

Gen i izražavanje[uredi - уреди | uredi izvor]

Ljudski ERBB3 gen je lociran na dugačkoj ruci hromozoma 12 (12q13). On je kodiran sa 23,651 parova baza i translira se u 1342 aminokiselina.[1]

Tokom razvića čoveka, ERBB3 je izražen u koži, kostima, mišićima, nervnom sistemu, srcu, plućima, i intestinalnom epitelu.[2] ERBB3 je izražed kod normalnih odraslih ljudi u gastrointestinalnom traktu, reproduktivnom sistemu, koži, nervnom sistemu, urinarnom trakti, i endokrinom sistemu.[3]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. "ERBB3 Gene - GeneCards | ERBB3 Protein". http://www.genecards.org/cgi-bin/carddisp.pl?gene=ERBB3. 
  2. Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, Seeburg PH, Libermann TA, Schlessinger J, Francke U (1985). "Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene". Science 230 (4730): 1132–9. PMID 2999974. doi:10.1126/science.2999974. 
  3. Prigent SA, Lemoine NR, Hughes CM, Plowman GD, Selden C, Gullick WJ (1992). "Expression of the c-erbB-3 protein in normal human adult and fetal tissues". Oncogene 7 (7): 1273–8. PMID 1377811. 

Literatura[uredi - уреди | uredi izvor]

  • Corfas G, Roy K, Buxbaum JD (2004). "Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia". Nat. Neurosci. 7 (6): 575–80. PMID 15162166. doi:10.1038/nn1258. 
  • Plowman GD, Whitney GS, Neubauer MG et al. (1990). "Molecular cloning and expression of an additional epidermal growth factor receptor-related gene". Proc. Natl. Acad. Sci. U.S.A. 87 (13): 4905–9. PMC 54229. PMID 2164210. doi:10.1073/pnas.87.13.4905. 
  • Kraus MH, Issing W, Miki T et al. (1990). "Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9193–7. PMC 298460. PMID 2687875. doi:10.1073/pnas.86.23.9193. 
  • Alimandi M, Romano A, Curia MC et al. (1995). "Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas". Oncogene 10 (9): 1813–21. PMID 7538656. 
  • Wallasch C, Weiss FU, Niederfellner G et al. (1995). "Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3". EMBO J. 14 (17): 4267–75. PMC 394510. PMID 7556068. 
  • Horan T, Wen J, Arakawa T et al. (1995). "Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3". J. Biol. Chem. 270 (41): 24604–8. PMID 7592681. doi:10.1074/jbc.270.41.24604. 
  • Shintani S, Funayama T, Yoshihama Y et al. (1995). "Prognostic significance of ERBB3 overexpression in oral squamous cell carcinoma". Cancer Lett. 95 (1–2): 79–83. PMID 7656248. doi:10.1016/0304-3835(95)03866-U. 
  • Katoh M, Yazaki Y, Sugimura T, Terada M (1993). "c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 192 (3): 1189–97. PMID 7685162. doi:10.1006/bbrc.1993.1542. 
  • Culouscou JM, Plowman GD, Carlton GW et al. (1993). "Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor". J. Biol. Chem. 268 (25): 18407–10. PMID 7689552. 
  • Zelada-Hedman M, Werer G, Collins P et al. (1995). "High expression of the EGFR in fibroadenomas compared to breast carcinomas". Anticancer Res. 14 (5A): 1679–88. PMID 7847801. 
  • Carraway KL, Sliwkowski MX, Akita R et al. (1994). "The erbB3 gene product is a receptor for heregulin". J. Biol. Chem. 269 (19): 14303–6. PMID 8188716. 
  • Shintani S, Funayama T, Yoshihama Y et al. (1996). "Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study". Anticancer Res. 15 (6B): 2623–6. PMID 8669836. 
  • Chang H, Riese DJ, Gilbert W et al. (1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature 387 (6632): 509–12. PMID 9168114. doi:10.1038/387509a0. 
  • Carraway KL, Weber JL, Unger MJ et al. (1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature 387 (6632): 512–6. PMID 9168115. doi:10.1038/387512a0. 
  • Fiddes RJ, Campbell DH, Janes PW et al. (1998). "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3". J. Biol. Chem. 273 (13): 7717–24. PMID 9516479. doi:10.1074/jbc.273.13.7717. 
  • Jones JT, Ballinger MD, Pisacane PI et al. (1998). "Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis". J. Biol. Chem. 273 (19): 11667–74. PMID 9565587. doi:10.1074/jbc.273.19.11667. 
  • Lee H, Maihle NJ (1998). "Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues". Oncogene 16 (25): 3243–52. PMID 9681822. doi:10.1038/sj.onc.1201866. 
  • Vijapurkar U, Cheng K, Koland JG (1998). "Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase". J. Biol. Chem. 273 (33): 20996–1002. PMID 9694850. doi:10.1074/jbc.273.33.20996. 
  • Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene 229 (1–2): 215–21. PMID 10095121. doi:10.1016/S0378-1119(98)00604-0. 
  • Lin J, Adam RM, Santiestevan E, Freeman MR (1999). "The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells". Cancer Res. 59 (12): 2891–7. PMID 10383151.