Abl (gen)

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ABL proto-onkogen 1, nereceptorska tirozinska kinaza

PDB prikaz baziran na 1ab2.
Dostupne strukture
1AB2, 1ABL, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2F4J, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2O88, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3PYY, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD
Identifikatori
SimboliABL1; ABL; JTK7; bcr/abl; c-ABL; c-ABL1; p150; v-abl
Vanjski IDOMIM189980 MGI87859 HomoloGene3783 GeneCards: ABL1 Gene
EC broj2.7.10.2
Pregled RNK izražavanja
PBB GE ABL1 202123 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez2511350
EnsemblENSG00000097007ENSMUSG00000026842
UniProtP00519P00520
Ref. Sekv. (iRNK)NM_005157NM_001112703
Ref. Sekv. (protein)NP_005148NP_001106174
Lokacija (UCSC)Chr 9:
133.59 - 133.76 Mb
Chr 2:
31.69 - 31.8 Mb
PubMed pretraga[1][2]

Abelsonov mišji leukemijski viralni onkogen homolog 1 (ABL1) protein je koji je kod ljudi kodiran ABL1 genom (raniji simbol ABL) lociranim na hromozomu 9.[1] c-Abl se ponekad koristi za imenovanje verzije gena prisutnog u genomu sisara, dok se v-Abl odnosi na viralni gen.

Interakcije[uredi - уреди | uredi izvor]

Abl gen formira interakcije sa:

Regulacija[uredi - уреди | uredi izvor]

Postoje izvesni dokazi da je izražavanje Abl regulisano posredstvom mikroRNK miR-203.[50]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

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Literatura[uredi - уреди | uredi izvor]

Vanjske veze[uredi - уреди | uredi izvor]