TEK tirozinska kinaza

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TEK tirozinska kinaza, endotelna

PDB prikaz baziran na 1fvr.
Dostupne strukture
1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3BEA, 3L8P, 4K0V
Identifikatori
SimboliTEK; CD202B; TIE-2; TIE2; VMCM; VMCM1
Vanjski IDOMIM600221 MGI98664 HomoloGene397 GeneCards: TEK Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE TEK 206702 at tn.png
PBB GE TEK 217711 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez701021687
EnsemblENSG00000120156ENSMUSG00000006386
UniProtQ02763Q02858
Ref. Sekv. (iRNK)NM_000459NM_001290549
Ref. Sekv. (protein)NP_000450NP_001277478
Lokacija (UCSC)Chr 9:
27.11 - 27.23 Mb
Chr 4:
94.74 - 94.87 Mb
PubMed pretraga[1][2]

Receptor angiopoietina 1 je protein koji je kod ljudi kodiran TEK genom.[1][2] TEK se takođe označava sa CD202B (klaster diferencijacije 202B).

TEK receptorska tirozinska kinaza je izražena skoro isključivo u endotelnim ćelijama kod miševa, pacova, i ljudi. Ovaj receptor poseduje jedinstveni ekstracelularni domen koji sadrži 2 imunoglobulinu slične petlje razdvojene sa 3 ponavljanja slična epidermalnom faktoru rasta koja su povezana sa 3 ponavljanja slična fibronektinu tipa III. Ligand ovog receptora je angiopoietin-1. Defekti u TEK su asocirani sa naslednim venskim malformacijama; TEK signalni put je kritičan za komunikaciju endotelnih ćelija i glatkih mišičnih ćelija tokom venske morfogeneze. TEK je blisko srodan sa TIE receptorskom tirozinskom kinazom.[3]

Interakcije[uredi - уреди | uredi kôd]

TEK tirozinska kinaza formira interakcije sa DOK2,[4][5] Angiopoietin 1[6][7][8][9] i ANGPT2.[6][8][9]

Reference[uredi - уреди | uredi kôd]

  1. Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). „A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains”. Mol Cell Biol 12 (4): 1698–707. PMC 369613. PMID 1312667. //www.ncbi.nlm.nih.gov/pmc/articles/PMC369613/. 
  2. Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (February 1995). „Assignment of a locus for dominantly inherited venous malformations to chromosome 9p”. Hum Mol Genet 3 (9): 1583–7. DOI:10.1093/hmg/3.9.1583. PMID 7833915. 
  3. „Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)”. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7010. 
  4. Jones, N; Dumont D J (September 1998). „The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R”. Oncogene (ENGLAND) 17 (9): 1097–108. DOI:10.1038/sj.onc.1202115. ISSN 0950-9232. PMID 9764820. 
  5. Master, Z; Jones N; Tran J; Jones J; Kerbel R S; Dumont D J (November 2001). „Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak”. EMBO J. (England) 20 (21): 5919–28. DOI:10.1093/emboj/20.21.5919. ISSN 0261-4189. PMC 125712. PMID 11689432. //www.ncbi.nlm.nih.gov/pmc/articles/PMC125712/. 
  6. 6,0 6,1 Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (January 2003). „Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats”. J. Biol. Chem. (United States) 278 (3): 1721–7. DOI:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764. 
  7. Davis, S; Aldrich T H, Jones P F, Acheson A, Compton D L, Jain V, Ryan T E, Bruno J, Radziejewski C, Maisonpierre P C, Yancopoulos G D (December 1996). „Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning”. Cell (UNITED STATES) 87 (7): 1161–9. DOI:10.1016/S0092-8674(00)81812-7. ISSN 0092-8674. PMID 8980223. 
  8. 8,0 8,1 Sato, A; Iwama A; Takakura N; Nishio H; Yancopoulos G D; Suda T (August 1998). „Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells”. Int. Immunol. (ENGLAND) 10 (8): 1217–27. DOI:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709. 
  9. 9,0 9,1 Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (July 1997). „Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis”. Science (UNITED STATES) 277 (5322): 55–60. DOI:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896. 

Literatura[uredi - уреди | uredi kôd]

Vanjske veze[uredi - уреди | uredi kôd]