TEK tirozinska kinaza

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TEK tirozinska kinaza, endotelna

PDB prikaz baziran na 1fvr.
Dostupne strukture
1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3BEA, 3L8P, 4K0V
Identifikatori
SimboliTEK; CD202B; TIE-2; TIE2; VMCM; VMCM1
Vanjski IDOMIM600221 MGI98664 HomoloGene397 GeneCards: TEK Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE TEK 206702 at tn.png
PBB GE TEK 217711 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez701021687
EnsemblENSG00000120156ENSMUSG00000006386
UniProtQ02763Q02858
Ref. Sekv. (iRNK)NM_000459NM_001290549
Ref. Sekv. (protein)NP_000450NP_001277478
Lokacija (UCSC)Chr 9:
27.11 - 27.23 Mb
Chr 4:
94.74 - 94.87 Mb
PubMed pretraga[1][2]

Receptor angiopoietina 1 je protein koji je kod ljudi kodiran TEK genom.[1][2] TEK se takođe označava sa CD202B (klaster diferencijacije 202B).

TEK receptorska tirozinska kinaza je izražena skoro isključivo u endotelnim ćelijama kod miševa, pacova, i ljudi. Ovaj receptor poseduje jedinstveni ekstracelularni domen koji sadrži 2 imunoglobulinu slične petlje razdvojene sa 3 ponavljanja slična epidermalnom faktoru rasta koja su povezana sa 3 ponavljanja slična fibronektinu tipa III. Ligand ovog receptora je angiopoietin-1. Defekti u TEK su asocirani sa naslednim venskim malformacijama; TEK signalni put je kritičan za komunikaciju endotelnih ćelija i glatkih mišičnih ćelija tokom venske morfogeneze. TEK je blisko srodan sa TIE receptorskom tirozinskom kinazom.[3]

Interakcije[uredi - уреди | uredi izvor]

TEK tirozinska kinaza formira interakcije sa DOK2,[4][5] Angiopoietin 1[6][7][8][9] i ANGPT2.[6][8][9]

Reference[uredi - уреди | uredi izvor]

  1. Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol Cell Biol 12 (4): 1698–707. PMC 369613. PMID 1312667. 
  2. Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (February 1995). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Hum Mol Genet 3 (9): 1583–7. PMID 7833915. doi:10.1093/hmg/3.9.1583. 
  3. "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7010. 
  4. Jones, N; Dumont D J (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene (ENGLAND) 17 (9): 1097–108. ISSN 0950-9232. PMID 9764820. doi:10.1038/sj.onc.1202115. 
  5. Master, Z; Jones N; Tran J; Jones J; Kerbel R S; Dumont D J (November 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. (England) 20 (21): 5919–28. ISSN 0261-4189. PMC 125712. PMID 11689432. doi:10.1093/emboj/20.21.5919. 
  6. 6,0 6,1 Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721–7. ISSN 0021-9258. PMID 12427764. doi:10.1074/jbc.M208550200. 
  7. Davis, S; Aldrich T H, Jones P F, Acheson A, Compton D L, Jain V, Ryan T E, Bruno J, Radziejewski C, Maisonpierre P C, Yancopoulos G D (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell (UNITED STATES) 87 (7): 1161–9. ISSN 0092-8674. PMID 8980223. doi:10.1016/S0092-8674(00)81812-7. 
  8. 8,0 8,1 Sato, A; Iwama A; Takakura N; Nishio H; Yancopoulos G D; Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. (ENGLAND) 10 (8): 1217–27. ISSN 0953-8178. PMID 9723709. doi:10.1093/intimm/10.8.1217. 
  9. 9,0 9,1 Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science (UNITED STATES) 277 (5322): 55–60. ISSN 0036-8075. PMID 9204896. doi:10.1126/science.277.5322.55. 

Literatura[uredi - уреди | uredi izvor]

  • Huang L, Turck CW, Rao P, Peters KG (1995). "GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.". Oncogene 11 (10): 2097–103. PMID 7478529. 
  • Deans JP, Kalt L, Ledbetter JA et al. (1995). "Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.". J. Biol. Chem. 270 (38): 22632–8. PMID 7545683. doi:10.1074/jbc.270.38.22632. 
  • Gallione CJ, Pasyk KA, Boon LM et al. (1995). "A gene for familial venous malformations maps to chromosome 9p in a second large kindred.". J. Med. Genet. 32 (3): 197–9. PMC 1050316. PMID 7783168. doi:10.1136/jmg.32.3.197. 
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. PMID 7829101. doi:10.1006/geno.1994.1457. 
  • Dumont DJ, Anderson L, Breitman ML, Duncan AM (1995). "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21.". Genomics 23 (2): 512–3. PMID 7835909. doi:10.1006/geno.1994.1536. 
  • Ziegler SF, Bird TA, Schneringer JA et al. (1993). "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.". Oncogene 8 (3): 663–70. PMID 8382358. 
  • Davis S, Aldrich TH, Jones PF et al. (1997). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.". Cell 87 (7): 1161–9. PMID 8980223. doi:10.1016/S0092-8674(00)81812-7. 
  • Suri C, Jones PF, Patan S et al. (1997). "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.". Cell 87 (7): 1171–80. PMID 8980224. doi:10.1016/S0092-8674(00)81813-9. 
  • Vikkula M, Boon LM, Carraway KL et al. (1997). "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.". Cell 87 (7): 1181–90. PMID 8980225. doi:10.1016/S0092-8674(00)81814-0. 
  • Witzenbichler B, Maisonpierre PC, Jones P et al. (1998). "Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2.". J. Biol. Chem. 273 (29): 18514–21. PMID 9660821. doi:10.1074/jbc.273.29.18514. 
  • Asahara T, Chen D, Takahashi T et al. (1998). "Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.". Circ. Res. 83 (3): 233–40. PMID 9710115. doi:10.1161/01.res.83.3.233. 
  • Sato A, Iwama A, Takakura N et al. (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells.". Int. Immunol. 10 (8): 1217–27. PMID 9723709. doi:10.1093/intimm/10.8.1217. 
  • Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.". Oncogene 17 (9): 1097–108. PMID 9764820. doi:10.1038/sj.onc.1202115. 
  • De Sepulveda P, Okkenhaug K, Rose JL et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904–15. PMC 1171183. PMID 10022833. doi:10.1093/emboj/18.4.904. 
  • Valenzuela DM, Griffiths JA, Rojas J et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. PMC 26709. PMID 10051567. doi:10.1073/pnas.96.5.1904. 
  • Calvert JT, Riney TJ, Kontos CD et al. (1999). "Allelic and locus heterogeneity in inherited venous malformations.". Hum. Mol. Genet. 8 (7): 1279–89. PMID 10369874. doi:10.1093/hmg/8.7.1279. 
  • Jones N, Master Z, Jones J et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.". J. Biol. Chem. 274 (43): 30896–905. PMID 10521483. doi:10.1074/jbc.274.43.30896. 
  • Fachinger G, Deutsch U, Risau W (1999). "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.". Oncogene 18 (43): 5948–53. PMID 10557082. doi:10.1038/sj.onc.1202992. 

Vanjske veze[uredi - уреди | uredi izvor]