EPH receptor A3

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EPH receptor A3

PDB prikaz baziran na 2gsf.
Dostupne strukture
2GSF, 2QO2, 2QO7, 2QO9, 2QOB, 2QOC, 2QOD, 2QOF, 2QOI, 2QOK, 2QOL, 2QON, 2QOO, 2QOQ, 3DZQ, 3FXX, 3FY2, 4G2F, 4GK2, 4GK3, 4GK4
Identifikatori
SimboliEPHA3; EK4; ETK; ETK1; HEK; HEK4; TYRO4
Vanjski IDOMIM179611 MGI99612 HomoloGene21083 GeneCards: EPHA3 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE EPHA3 206070 s at tn.png
PBB GE EPHA3 206071 s at tn.png
PBB GE EPHA3 gnf1h09694 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez204213837
EnsemblENSG00000044524ENSMUSG00000052504
UniProtP29320P29319
Ref. Sekv. (iRNK)NM_005233NM_010140
Ref. Sekv. (protein)NP_005224NP_034270
Lokacija (UCSC)Chr 3:
89.16 - 89.53 Mb
Chr 16:
63.54 - 63.86 Mb
PubMed pretraga[1][2]

EPH receptor A3 (efrinski receptor 3 tipa A) protein je koji je kod ljudi kodiran EPHA3 genom.[1][2][3]

Ovaj gen je pripadnik grupe efrinskih receptora iz familije proteinskih turozinskih kinaza. EPH i EPH-srodni receptori uzimaju učešća u posredovanju događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B.[3]

Interakcije[uredi - уреди | uredi izvor]

EPH receptor A3 formira interakcije sa EFNB2[4][5] i EFNA5.[5][6]

Reference[uredi - уреди | uredi izvor]

  1. Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I (March 1992). "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line". J Biol Chem 267 (5): 3262–7. PMID 1737782. 
  2. Wicks IP, Wilkinson D, Salvaris E, Boyd AW (April 1992). "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines". Proc Natl Acad Sci U S A 89 (5): 1611–5. PMC 48502. PMID 1311845. doi:10.1073/pnas.89.5.1611. 
  3. 3,0 3,1 "Entrez Gene: EPHA3 EPH receptor A3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2042. 
  4. Cerretti, D P; Vanden Bos T; Nelson N; Kozlosky C J; Reddy P; Maraskovsky E; Park L S; Lyman S D; Copeland N G; Gilbert D J (November 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Mol. Immunol. (ENGLAND) 32 (16): 1197–205. ISSN 0161-5890. PMID 8559144. doi:10.1016/0161-5890(95)00108-5. 
  5. 5,0 5,1 Lackmann, M; Mann R J, Kravets L, Smith F M, Bucci T A, Maxwell K F, Howlett G J, Olsson J E, Vanden Bos T, Cerretti D P, Boyd A W (June 1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor". J. Biol. Chem. (UNITED STATES) 272 (26): 16521–30. ISSN 0021-9258. PMID 9195962. doi:10.1074/jbc.272.26.16521. 
  6. Kozlosky, C J; VandenBos T; Park L; Cerretti D P; Carpenter M K (August 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine (UNITED STATES) 9 (8): 540–9. ISSN 1043-4666. PMID 9245480. doi:10.1006/cyto.1997.0199. 

Literatura[uredi - уреди | uredi izvor]