EPH receptor A5

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EPH receptor A5
Dostupne strukture
2R2P, 4ET7
Identifikatori
SimboliEPHA5; CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4
Vanjski IDOMIM600004 MGI99654 HomoloGene55824 GeneCards: EPHA5 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE EPHA5 215664 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez204413839
EnsemblENSG00000145242ENSMUSG00000029245
UniProtP54756Q60629
Ref. Sekv. (iRNK)NM_001281765NM_007937
Ref. Sekv. (protein)NP_001268694NP_031963
Lokacija (UCSC)Chr 4:
66.19 - 66.54 Mb
Chr 5:
84.06 - 84.42 Mb
PubMed pretraga[1][2]

Receptor 5 efrinskog tipa A je protein koji je kod ljudi kodiran EPHA5 genom.[1][2][3]

Ovaj gen je pripadnik grupe efrinskih receptora iz familije proteinskih turozinskih kinaza. EPH i EPH-srodni receptori uzimaju učešća u posredovanju događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B.[3]

Reference[uredi - уреди | uredi izvor]

  1. Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. PMID 9267020. doi:10.1016/S0092-8674(00)80500-0.  Check date values in: |date= (help)
  2. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics 22 (2): 431–6. PMID 7528718. doi:10.1006/geno.1994.1405.  Check date values in: |date= (help)
  3. 3,0 3,1 "Entrez Gene: EPHA5 EPH receptor A5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2044. 

Literatura[uredi - уреди | uredi izvor]

  • Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands.". Cell Tissue Res. 290 (2): 251–9. PMID 9321686. doi:10.1007/s004410050929. 
  • Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1.". Cell Tissue Res. 290 (2): 261–4. PMID 9321687. doi:10.1007/s004410050930. 
  • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. PMID 9530499. doi:10.1146/annurev.neuro.21.1.309. 
  • Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626. doi:10.1016/S0163-7258(97)00112-5. 
  • Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129. 
  • Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216. doi:10.1016/S0074-7696(00)96005-4. 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. PMC 1692797. PMID 11128993. doi:10.1098/rstb.2000.0635. 
  • Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076. doi:10.1038/35058515. 
  • Fox GM, Holst PL, Chute HT et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.". Oncogene 10 (5): 897–905. PMID 7898931. 
  • Davis S, Gale NW, Aldrich TH et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.". Science 266 (5186): 816–9. PMID 7973638. doi:10.1126/science.7973638. 
  • Gale NW, Holland SJ, Valenzuela DM et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. PMID 8755474. doi:10.1016/S0896-6273(00)80276-7. 
  • Miescher GC, Taylor V, Olivieri G et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.". Brain Res. Mol. Brain Res. 46 (1-2): 17–24. PMID 9191074. doi:10.1016/S0169-328X(96)00268-9. 
  • Stein E, Savaskan NE, Ninnemann O et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting.". J. Neurosci. 19 (20): 8885–93. PMID 10516308.