TrkB receptor

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Neurotrofna tirozinska kinaza, receptor, tip 2

PDB prikaz baziran na 1hcf.
Dostupne strukture
1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4, 4AT5
Identifikatori
SimboliNTRK2; GP145-TrkB; TRKB; trk-B
Vanjski IDOMIM600456 MGI97384 HomoloGene4504 GeneCards: NTRK2 Gene
EC broj2.7.10.1
Pregled RNK izražavanja
PBB GE NTRK2 207152 at tn.png
PBB GE NTRK2 214680 at tn.png
PBB GE NTRK2 221795 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez491518212
EnsemblENSG00000148053ENSMUSG00000055254
UniProtQ16620P15209
Ref. Sekv. (iRNK)NM_001007097NM_001025074
Ref. Sekv. (protein)NP_001007098NP_001020245
Lokacija (UCSC)Chr 9:
87.28 - 87.64 Mb
Chr 13:
58.81 - 59.13 Mb
PubMed pretraga[1][2]

TrkB receptor (TrkB tirozinska kinaza, receptor BDNF/NT-3 faktora rasta, receptorska neurotrofna tirozinska kinaza, tip 2) protein je koji je kod ljudi kodiran NTRK2 genom.[1]

Interakcije[uredi - уреди | uredi izvor]

TrkB formira interakcije sa:

Ligandi[uredi - уреди | uredi izvor]

Agonisti[uredi - уреди | uredi izvor]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Nakagawara A, Liu XG, Ikegaki N, White PS, Yamashiro DJ, Nycum LM, Biegel JA, Brodeur GM (January 1995). "Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)". Genomics 25 (2): 538–46. PMID 7789988. doi:10.1016/0888-7543(95)80055-Q. 
  2. Haniu M, Montestruque S, Bures EJ, Talvenheimo J, Toso R, Lewis-Sandy S, Welcher AA, Rohde MF (October 1997). "Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking". J. Biol. Chem. 272 (40): 25296–303. PMID 9312147. doi:10.1074/jbc.272.40.25296. 
  3. Naylor RL, Robertson AG, Allen SJ, Sessions RB, Clarke AR, Mason GG, Burston JJ, Tyler SJ, Wilcock GK, Dawbarn D (March 2002). "A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4". Biochem. Biophys. Res. Commun. 291 (3): 501–7. PMID 11855816. doi:10.1006/bbrc.2002.6468. 
  4. Iwasaki Y, Gay B, Wada K, Koizumi S (July 1998). "Association of the Src family tyrosine kinase Fyn with TrkB". J. Neurochem. 71 (1): 106–11. PMID 9648856. doi:10.1046/j.1471-4159.1998.71010106.x. 
  5. 5,0 5,1 5,2 Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. 294 (5): 1087–92. PMID 12074588. doi:10.1016/S0006-291X(02)00606-X. 
  6. Meakin SO, MacDonald JI, Gryz EA, Kubu CJ, Verdi JM (April 1999). "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation". J. Biol. Chem. 274 (14): 9861–70. PMID 10092678. doi:10.1074/jbc.274.14.9861. 
  7. Geetha T, Wooten MW (February 2003). "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling". J. Biol. Chem. 278 (7): 4730–9. PMID 12471037. doi:10.1074/jbc.M208468200. 
  8. Nakamura T, Muraoka S, Sanokawa R, Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. 273 (12): 6960–7. PMID 9507002. doi:10.1074/jbc.273.12.6960. 
  9. PMID 19549602
  10. Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K (November 2010). "A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect". J Med Chem 53: 8274. PMID 21073191. doi:10.1021/jm101206p. 
  11. {{Cite http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011528 }}

Literatura[uredi - уреди | uredi izvor]

  • Klein R, Conway D, Parada LF, Barbacid M (May 1990). "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain". Cell 61 (4): 647–56. PMID 2160854. doi:10.1016/0092-8674(90)90476-U. 
  • Squinto SP, Stitt TN, Aldrich TH, Davis S, Bianco SM, Radziejewski C, Glass DJ, Masiakowski P, Furth ME, Valenzuela DM (May 1991). "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell 65 (5): 885–93. PMID 1710174. doi:10.1016/0092-8674(91)90395-F. 
  • Rose CR, Blum R, Pichler B, Lepier A, Kafitz KW, Konnerth A (November 2003). "Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells". Nature 426 (6962): 74–8. PMID 14603320. doi:10.1038/nature01983. 
  • Ohira K, Kumanogoh H, Sahara Y, Homma KJ, Hirai H, Nakamura S, Hayashi M (February 2005). "A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1". J. Neurosci. 25 (6): 1343–53. PMID 15703388. doi:10.1523/JNEUROSCI.4436-04.2005. 
  • Yamada K, Nabeshima T (2004). "Brain-derived neurotrophic factor/TrkB signaling in memory processes.". J. Pharmacol. Sci. 91 (4): 267–70. PMID 12719654. doi:10.1254/jphs.91.267. 
  • Soppet D, Escandon E, Maragos J et al. (1991). "The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.". Cell 65 (5): 895–903. PMID 1645620. doi:10.1016/0092-8674(91)90396-G. 
  • Squinto SP, Stitt TN, Aldrich TH et al. (1991). "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.". Cell 65 (5): 885–93. PMID 1710174. doi:10.1016/0092-8674(91)90395-F. 
  • Haniu M, Talvenheimo J, Le J et al. (1995). "Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding.". Arch. Biochem. Biophys. 322 (1): 256–64. PMID 7574684. doi:10.1006/abbi.1995.1460. 
  • Ip NY, Stitt TN, Tapley P et al. (1993). "Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.". Neuron 10 (2): 137–49. PMID 7679912. doi:10.1016/0896-6273(93)90306-C. 
  • Slaugenhaupt SA, Blumenfeld A, Liebert CB et al. (1995). "The human gene for neurotrophic tyrosine kinase receptor type 2 (NTRK2) is located on chromosome 9 but is not the familial dysautonomia gene.". Genomics 25 (3): 730–2. PMID 7759111. doi:10.1016/0888-7543(95)80019-I. 
  • Shelton DL, Sutherland J, Gripp J et al. (1995). "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.". J. Neurosci. 15 (1 Pt 2): 477–91. PMID 7823156. 
  • Allen SJ, Dawbarn D, Eckford SD et al. (1994). "Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.". Neuroscience 60 (3): 825–34. PMID 7936202. doi:10.1016/0306-4522(94)90507-X. 
  • Rydén M, Ibáñez CF (1996). "Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC.". J. Biol. Chem. 271 (10): 5623–7. PMID 8621424. doi:10.1074/jbc.271.10.5623. 
  • Yamamoto M, Sobue G, Yamamoto K et al. (1997). "Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.". Neurochem. Res. 21 (8): 929–38. PMID 8895847. doi:10.1007/BF02532343. 
  • Valent A, Danglot G, Bernheim A (1997). "Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization.". Eur. J. Hum. Genet. 5 (2): 102–4. PMID 9195161. 
  • Haniu M, Montestruque S, Bures EJ et al. (1997). "Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking.". J. Biol. Chem. 272 (40): 25296–303. PMID 9312147. doi:10.1074/jbc.272.40.25296. 
  • Nakamura T, Muraoka S, Sanokawa R, Mori N (1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.". J. Biol. Chem. 273 (12): 6960–7. PMID 9507002. doi:10.1074/jbc.273.12.6960. 
  • Hackett SF, Friedman Z, Freund J et al. (1998). "A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics.". Brain Res. 789 (2): 201–12. PMID 9573364. doi:10.1016/S0006-8993(97)01440-6. 
  • Iwasaki Y, Gay B, Wada K, Koizumi S (1998). "Association of the Src family tyrosine kinase Fyn with TrkB.". J. Neurochem. 71 (1): 106–11. PMID 9648856. doi:10.1046/j.1471-4159.1998.71010106.x. 
  • Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons.". Neuron 21 (5): 1017–29. PMID 9856458. doi:10.1016/S0896-6273(00)80620-0. 
  • Bibel M, Hoppe E, Barde YA (1999). "Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.". EMBO J. 18 (3): 616–22. PMC 1171154. PMID 9927421. doi:10.1093/emboj/18.3.616. 
  • Yamada M, Ohnishi H, Sano S et al. (1999). "Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons.". J. Neurochem. 73 (1): 41–9. PMID 10386953. doi:10.1046/j.1471-4159.1999.0730041.x. 
  • Ultsch MH, Wiesmann C, Simmons LC et al. (1999). "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.". J. Mol. Biol. 290 (1): 149–59. PMID 10388563. doi:10.1006/jmbi.1999.2816. 

Vanjske veze[uredi - уреди | uredi izvor]