Bromizoval

Bromizoval
	(RS)-2-Bromo-N-karbamoil-3-metilbutanamid
Identifikacija
CAS registarski broj	496-67-3 , 27109-49-5 R
PubChem	2447, ; 146955 R, ; 735997 S
ChemSpider	2353 , 129594 R , 643139 S
UNII	469GW8R486
EINECS broj	207-825-7
KEGG	D01391
MeSH	Bromisovalum
ChEMBL	CHEMBL1515611
ATC code	N05CM03
Jmol-3D slike	Slika 1; Slika 2
SMILES
	CC(C)C(Br)c(:[o]):[nH]:c(:[nH2]):[o] CC(C)C(Br)C(=O)NC(N)=O
InChI
	InChI=1S/C6H11BrN2O2/c1-3(2)4(7)5(10)9-6(8)11/h3-4H,1-2H3,(H3,8,9,10,11) ; Kod: CMCCHHWTTBEZNM-UHFFFAOYSA-N
Svojstva
Molekulska formula	C6H11BrN2O2
Molarna masa	223.07 g mol−1
log P	1,057
pKa	10,536
Baznost (pKb)	3;461
Farmakologija
Načini upotrebe	Oralno
Srodna jedinjenja
Srodna ureje	Karbromal
Srodna jedinjenja	3-Ureidopropionska kiselina; beta-Ureidoizobutirinska kiselina; Karbamoil aspartinska kiselina; N-Acetilaspartinska kiselina; Aceglutamid; N-Acetilglutaminska kiselina; Citrulin;
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Bromizoval (bromvalerilureja) je hipnotik i sedativ koji je bio otkriven 1907.^[6] One je u prodaji na slobodno u Aziji pod mnoštvom naziva (kao što je Brovarin^[7]). On se obično koristi u kombinaciji sa nesteroidnim antiinflamatornim lekovima.

Hronična upotreba bromizovala je vezana za trovanje bromom.^[8]^[9]^[10]^[11]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ US patent 914518, "Alpha-halogen-isovaleryl-urea and process of making the same", issued 09. 03. 1909., assigned to Knoll
↑ „Bromisoval”. International. Drugs.com.
↑ Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). „A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia” (japanese) (pdf). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 38 (5): 700–703. DOI:10.3143/geriatrics.38.700. ISSN 0300-9173. PMID 11605223.
↑ Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). „Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse” (pdf). Internal Medicine (Tokyo, Japan) 37 (9): 788–791. DOI:10.2169/internalmedicine.37.788. PMID 9804091.
↑ Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). „Pseudohyperchloraemia due to bromvalerylurea abuse”. Nephrology Dialysis Transplantation 20 (8): 1767–1768. DOI:10.1093/ndt/gfh945. PMID 15972320.
↑ Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). „Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning” (pdf). Internal Medicine (Tokyo, Japan) 36 (10): 742–746. DOI:10.2169/internalmedicine.36.742. PMID 9372340.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] US patent 914518, "Alpha-halogen-isovaleryl-urea and process of making the same", issued 09. 03. 1909., assigned to Knoll

[7] „Bromisoval”. International. Drugs.com.

[8] Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). „A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia” (japanese) (pdf). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 38 (5): 700–703. DOI:10.3143/geriatrics.38.700. ISSN 0300-9173. PMID 11605223.

[9] Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). „Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse” (pdf). Internal Medicine (Tokyo, Japan) 37 (9): 788–791. DOI:10.2169/internalmedicine.37.788. PMID 9804091.

[10] Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). „Pseudohyperchloraemia due to bromvalerylurea abuse”. Nephrology Dialysis Transplantation 20 (8): 1767–1768. DOI:10.1093/ndt/gfh945. PMID 15972320.

[11] Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). „Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning” (pdf). Internal Medicine (Tokyo, Japan) 36 (10): 742–746. DOI:10.2169/internalmedicine.36.742. PMID 9372340.

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Bromizoval

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