Pirolohinolin hinon

Izvor: Wikipedia
Pirolohinolin hinon
Pyrroloquinoline quinone.svg
Identifikacija
CAS registarski broj 72909-34-3 YesY
PubChem[1][2] 1024
ChemSpider[3] 997 YesY
KEGG[4] C00113
MeSH PQQ+Cofactor
ChEBI 18315
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C14H6N2O8
Molarna masa 330.21 g mol−1
Gustina 1,963 g/cm3
Opasnost
Tačka paljenja 569,8 °C

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
Infobox references

Pirolohinolin hinon (PQQ) je redoks kofaktor kod bakterija .[5][6][7][8] PQQ je prostetička grupa u metanolnoj dehidrogenazi metilotrofa, kao što je bakterijska vrsta Acetobacter.[9]

Enzimi koji sadrže PQQ se nazivaju hinoproteini. Glukozna dehidrogenaza, jedan od hinoproteina, se koristi kao glukozni senzor. Utvrđeno je da PQQ stimuliše rast bakterija.[10] Osim toga, on ima antioksidansno i neuroprotektivno dejstvo.[11]

PQQ biosinteza kod bakterija počinje sa proteinskom biosintezom kojom se formira kratki peptid, PqqA, na ribozomu. Svi atomi u PQQ su izvedeni iz glutaminske kiseline i tirozina u PqqA, koji se povezuju posrestvom radikalnog SAM enzima PqqE.[12]

Reference[uredi - уреди]

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. DOI:<48::AID-YEA2>3.0.CO;2-H 10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑ Hauge JG (1964). "Glucose dehydrogenase of bacterium anitratum: an enzyme with a novel prosthetic group". J Biol Chem 239: 3630–9. PMID 14257587. 
  6. ↑ Anthony C, Zatman LJ (1967). "The microbial oxidation of methanol. The prosthetic group of the alcohol dehydrogenase of Pseudomonas sp. M27: a new oxidoreductase prosthetic group". Biochem J 104 (3): 960–9. PMID 6049934. 
  7. ↑ Salisbury SA, Forrest HS, Cruse WB, Kennard O (1979). "A novel coenzyme from bacterial primary alcohol dehydrogenases". Nature 280 (5725): 843–4. DOI:10.1038/280843a0. PMID 471057. 
  8. ↑ Westerling J, Frank J, Duine JA (1979). "The prosthetic group of methanol dehydrogenase from Hyphomicrobium X: electron spin resonance evidence for a quinone structure". Biochem Biophys Res Commun 87 (3): 719–24. DOI:10.1016/0006-291X(79)92018-7. PMID 222269. 
  9. ↑ Ameyama M, Matsushita K, Ohno Y, Shinagawa E, Adachi O (1981). "Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria". FEBS Lett 130 (2): 179–83. DOI:10.1016/0014-5793(81)81114-3. PMID 6793395. 
  10. ↑ Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Pyrroloquinoline quinone: excretion by methylotrophs and growth stimulation for microorganisms". BioFactors 1 (1): 51–3. PMID 2855583. 
  11. ↑ Rucker R, Chowanadisai W, Nakano M. (2009). "Potential physiological importance of pyrroloquinoline quinone". Altern Med Rev. 14 (3): 179–83. 
  12. ↑ Puehringer S, Metlitzky M, Schwarzenbacher R (2008). "The pyrroloquinoline quinone biosynthesis pathway revisited: a structural approach.". BMC Biochem. 9: 8. PMID 18371220. 

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