Koenzim B
Koenzim B | |||
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IUPAC ime |
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Identifikacija | |||
CAS registarski broj | 104302-77-4 ![]() | ||
PubChem[1][2] | 350 | ||
ChemSpider[3] | 343 ![]() | ||
Jmol-3D slike | Slika 1 Slika 2 | ||
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Svojstva | |||
Molekulska formula | C11H22NO7PS | ||
Molarna masa | 343,333641 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
Koenzim B je koenzim koji je neophodan za redoks reakije u metanogenima. Puno hemijski naziv koenzima B je 7-merkaptoheptanoiltreoninfosfat.[4] Ovaj molekul sadrži tiol, koji je glavno mesto reakcije.
Koenzim B reaguje sa 2-metiltioetansulfonatom (metil-koenzimom M, skraćeno CH3–S–CoM), pri čemu se formira metan u metanogenezi:[5]
- CH3–S–CoM + HS–CoB → CH4 + CoB–S–S–CoM
Ovu konverziju katalizuje enzim metil koenzim M reduktaza, koja sadrži kofaktor F430 kao prostetičku grupu.
Srodna konverzija koja koristi HS-CoB i HS-CoM je redukcija fumarata do sukcinata, katalizovana fumarat reduktazom:[6]
- CH3–S–CoM + HS–CoB –O2CCH=CHCO2- → –O2CCH2–CH2CO2- + CoB–S–S–CoM
Reference[uredi - уреди | uredi izvor]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.
- ↑ Noll KM, Rinehart KL, Tanner RS, Wolfe RS (1986). "Structure of component B (7-mercaptoheptanoylthreonine phosphate) of the methylcoenzyme M methylreductase system of Methanobacterium thermoautotrophicum". Proc. Natl. Acad. Sci. U.S.A. 83 (12): 4238–42. PMC 323707. PMID 3086878. doi:10.1073/pnas.83.12.4238.
- ↑ Thauer RK (September 1998). "Biochemistry of methanogenesis: a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture". Microbiology 144 (Pt 9): 2377–406. PMID 9782487. doi:10.1099/00221287-144-9-2377.
- ↑ Heim S, Künkel A, Thauer RK, Hedderich R (April 1998). "Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum—identification of the catalytic sites for fumarate reduction and thiol oxidation". Eur. J. Biochem. 253 (1): 292–9. PMID 9578488. doi:10.1046/j.1432-1327.1998.2530292.x.
Spoljašnje veze[uredi - уреди | uredi izvor]
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