Aminoglikozid

Izvor: Wikipedia

Aminoglikozid je molekul ili deo molekula koji se sastoji od amino-modifikovanog šećera.[1]

Brojni aminoglikozidi delujz kao antibiotici. Među njima su amikacin, arbekacin, gentamicin, kanamicin, neomicin, netilmicin, paromomicin, rodostreptomicin,[2] streptomicin, tobramicin, i apramicin[3].

Nomenklatura[uredi - уреди]

Aminoglikozidi koji koji su izvedeni iz bakterija Streptomyces roda i oni koji su izvedeni iz Micromonospora[4] imaju sufiks -micin.[5]

Ovaj sistem nomenklature nije specifičan za aminoglikozide. Na primer, vankomicin[6] je glikopeptidni antibiotik, kao i eritromicin, koji se dobija od vrste Saccharopolyspora erythraea (ranije misklasifikovane kao Streptomyces) zajedno sa njegovim sintetičkim derivatima klaritromicinom i azitromicinom, je makrolid.[7][8]

Primeri[uredi - уреди]

Literatura[uredi - уреди]

  1. MeSH Aminoglycosides
  2. "Bacterial 'battle for survival' leads to new antibiotic" (Press release). Massachusetts Institute of Technology. 26. 2. 2008. Retrieved 1. 12. 2010.. 
  3. Ryden, R; Moore (1977). "BJ". J Antimicrob Chemother 3 (6): 609–613. 
  4. Kroppenstedt RM, Mayilraj S, Wink JM (Jun 2005). "Eight new species of the genus Micromonospora, Micromonospora citrea sp. nov., Micromonospora echinaurantiaca sp. nov., Micromonospora echinofusca sp. nov. Micromonospora fulviviridis sp. nov., Micromonospora inyonensis sp. nov., Micromonospora peucetia sp. nov., Micromonospora sagamiensis sp. nov., and Micromonospora viridifaciens sp. nov". Syst Appl Microbiol. 28 (4): 328–39. PMID 15997706. 
  5. Paul M. Dewick (2009). Medicinal Natural Products: A Biosynthetic Approach (3rd ed izd.). Wiley. ISBN 0470741678. 
  6. Walter P. Hammes1 and Francis C. Neuhaus (1974). "On the Mechanism of Action of Vancomycin: Inhibition of Peptidoglycan Synthesis in Gaffkya homari" 6 (6): 722–728. 
  7. Protein synthesis inhibitors: macrolides mechanism of action animation. Classification of agents Pharmamotion. Author: Gary Kaiser. The Community College of Baltimore County. Retrieved on July 31, 2009
  8. The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome Martin Lovmar and Måns Ehrenberg

Vanjske veze[uredi - уреди]