ERBB3

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V-erb-b2 ptičiji eritroblastni leukemijski viralni onkogeni homolog 3
PDB prikaz baziran na 1m6b.
Dostupne strukture
1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59
Identifikatori
Simboli	ERBB3; ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3
Vanjski ID	OMIM: 190151 MGI: 95411 HomoloGene: 20457 GeneCards: ERBB3 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost proteinske tirozinske kinaze • aktivnost transmembranskog signalnog receptora • proteinsko vezivanje Ćelijska komponenta • ekstracelularni prostor • ćelijska membrana • integralna komponenta ćelijske membrane Biološki proces • proteinska fosforilacija • negativna regulacija ćelijske adhezije • prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2065	13867
Ensembl	ENSG00000065361	ENSMUSG00000018166
UniProt	P21860	Q61526
Ref. Sekv. (iRNK)	NM_001005915	NM_010153
Ref. Sekv. (protein)	NP_001005915	NP_034283
Lokacija (UCSC)	Chr 12: 56.47 - 56.5 Mb	Chr 10: 128.57 - 128.59 Mb
PubMed pretraga	[1]	[2]

Receptorska tirozinska proteinska kinaza erbB-3 (HER3, receptor 3 ljudskog epidermalnog faktora rasta) membranski je protein koji je kod ljudi kodiran ERBB3 genom. ErbB3 je član familjie receptora epidermalnog faktora rasta (EGFR/ERBB) koji su receptorske tirozinske kinaze.

Gen i izražavanje

Ljudski ERBB3 gen je lociran na dugačkoj ruci hromozoma 12 (12q13). On je kodiran sa 23,651 parova baza i translira se u 1342 aminokiselina.

Tokom razvića čoveka, ERBB3 je izražen u koži, kostima, mišićima, nervnom sistemu, srcu, plućima, i intestinalnom epitelu. ERBB3 je izražed kod normalnih odraslih ljudi u gastrointestinalnom traktu, reproduktivnom sistemu, koži, nervnom sistemu, urinarnom trakti, i endokrinom sistemu.

Povezano

• Receptoraska familjia epidermalnih faktora rasta
• Receptor epidermalnog faktora rasta
• Receptorska tirozinska kinaza

Literatura

• Corfas G, Roy K, Buxbaum JD (2004). „Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia”. Nat. Neurosci. 7 (6): 575–80. DOI:10.1038/nn1258. PMID 15162166. 
• Plowman GD, Whitney GS, Neubauer MG, et al. (1990). „Molecular cloning and expression of an additional epidermal growth factor receptor-related gene”. Proc. Natl. Acad. Sci. U.S.A. 87 (13): 4905–9. DOI:10.1073/pnas.87.13.4905. PMC 54229. PMID 2164210. 
• Kraus MH, Issing W, Miki T, et al. (1990). „Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors”. Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9193–7. DOI:10.1073/pnas.86.23.9193. PMC 298460. PMID 2687875. 
• Alimandi M, Romano A, Curia MC, et al. (1995). „Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas”. Oncogene 10 (9): 1813–21. PMID 7538656. 
• Wallasch C, Weiss FU, Niederfellner G, et al. (1995). „Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3”. EMBO J. 14 (17): 4267–75. PMC 394510. PMID 7556068. 
• Horan T, Wen J, Arakawa T, et al. (1995). „Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3”. J. Biol. Chem. 270 (41): 24604–8. DOI:10.1074/jbc.270.41.24604. PMID 7592681. 
• Shintani S, Funayama T, Yoshihama Y, et al. (1995). „Prognostic significance of ERBB3 overexpression in oral squamous cell carcinoma”. Cancer Lett. 95 (1–2): 79–83. DOI:10.1016/0304-3835(95)03866-U. PMID 7656248. 
• Katoh M, Yazaki Y, Sugimura T, Terada M (1993). „c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase”. Biochem. Biophys. Res. Commun. 192 (3): 1189–97. DOI:10.1006/bbrc.1993.1542. PMID 7685162. 
• Culouscou JM, Plowman GD, Carlton GW, et al. (1993). „Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor”. J. Biol. Chem. 268 (25): 18407–10. PMID 7689552. 
• Zelada-Hedman M, Werer G, Collins P, et al. (1995). „High expression of the EGFR in fibroadenomas compared to breast carcinomas”. Anticancer Res. 14 (5A): 1679–88. PMID 7847801. 
• Carraway KL, Sliwkowski MX, Akita R, et al. (1994). „The erbB3 gene product is a receptor for heregulin”. J. Biol. Chem. 269 (19): 14303–6. PMID 8188716. 
• Shintani S, Funayama T, Yoshihama Y, et al. (1996). „Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study”. Anticancer Res. 15 (6B): 2623–6. PMID 8669836. 
• Chang H, Riese DJ, Gilbert W, et al. (1997). „Ligands for ErbB-family receptors encoded by a neuregulin-like gene”. Nature 387 (6632): 509–12. DOI:10.1038/387509a0. PMID 9168114. 
• Carraway KL, Weber JL, Unger MJ, et al. (1997). „Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases”. Nature 387 (6632): 512–6. DOI:10.1038/387512a0. PMID 9168115. 
• Fiddes RJ, Campbell DH, Janes PW, et al. (1998). „Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3”. J. Biol. Chem. 273 (13): 7717–24. DOI:10.1074/jbc.273.13.7717. PMID 9516479. 
• Jones JT, Ballinger MD, Pisacane PI, et al. (1998). „Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis”. J. Biol. Chem. 273 (19): 11667–74. DOI:10.1074/jbc.273.19.11667. PMID 9565587. 
• Lee H, Maihle NJ (1998). „Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues”. Oncogene 16 (25): 3243–52. DOI:10.1038/sj.onc.1201866. PMID 9681822. 
• Vijapurkar U, Cheng K, Koland JG (1998). „Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase”. J. Biol. Chem. 273 (33): 20996–1002. DOI:10.1074/jbc.273.33.20996. PMID 9694850. 
• Yoo JY, Hamburger AW (1999). „Interaction of the p23/p198 protein with ErbB-3”. Gene 229 (1–2): 215–21. DOI:10.1016/S0378-1119(98)00604-0. PMID 10095121. 
• Lin J, Adam RM, Santiestevan E, Freeman MR (1999). „The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells”. Cancer Res. 59 (12): 2891–7. PMID 10383151.