GPI (gen)

Glukoza fosfat izomeraza
	; PDB prikaz baziran na 1dqr.
Dostupne strukture
	1dqr, 1g98, 1gzd, 1gzv, 1hm5, 1hox, 1iat, 1iri, 1jiq, 1jlh, 1koj, 1n8t, 1nuh, 1xtb
Identifikatori
Simboli	GPI; PGI; AMF; GNPI; NLK; PHI; SA-36
Vanjski ID	OMIM: 172400 MGI: 95797 HomoloGene: 145 GeneCards: GPI Gene
EC broj	5.3.1.9
Ontologija gena
Molekularna funkcija	• aktivnost glukoza-6-fosfat izomeraze; • citokinska aktivnost; • aktivnost faktora rasta; • aktivnost izomeraze;
Celularna komponenta	• ekstracelularni prostor;
Biološki proces	• ugljenohidratni metabolički proces; • glukoneogeneza; • glikoliza; • humoralni imunski respons; • razvoj nervnog sistema; • hemotaksa;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Glukoza fosfat izomeraza‎, takođe poznata kao GPI, je ljudski protein kodiran GPI genom.^[1]

Funkcije[uredi | uredi kod]

Ovaj gen pripada GPI familiji čiji članovi kodiraju multifunkcionalne fosfoglukozne izomeraze koje učestvuje u energetskim putevima. Protein kodiran ovim genom je dimerni enzim koji katalizuje reverzibilne izomerizacije glukoze 6-fosfata i fruktoze 6-fosfata.

glukoza 6-fosfat <=> fruktoza 6-fosfat

GPI ima različite funkcije unutar i izvan ćelije. U citoplazmi, ovaj protein učestvuje u glikolizi i glukoneogenezi, dok van ćelije on funkcioniše kao neurotrofilni faktor za kičmene i senzorske neurone. Identičan protein izlučuju ćelije raka. Protein izlučen iz tih ćelija je poznat kao autokrini faktor motiliteta^[2]. On stimuliše metastazu.^[3] Defekti ovog gena mogu da prouzrokuju nonsferocitnu hemolitičku anemiju, i jaka enzimska deficijencija može biti asocirana sa hydrops fetalis, brzom neonatalnom smrću i neurološkim oštećenjima.^[1]

Reference[uredi | uredi kod]

↑ ^1,0 ^1,1 „Entrez Gene: GPI glucose phosphate isomerase”.
↑ Dobashi Y, Watanabe H, Sato Y, et al. (December 2006). „Differential expression and pathological significance of autocrine motility factor/glucose-6-phosphate isomerase expression in human lung carcinomas”. J. Pathol. 210 (4): 431–40. DOI:10.1002/path.2069. PMID 17029220.
↑ Watanabe H, Takehana K, Date M, Shinozaki T, Raz A (1996-07-01). „Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide”. Cancer Res. 56 (13): 2960–3. PMID 8674049.

Literatura[uredi | uredi kod]

Kugler W, Lakomek M (2000). „Glucose-6-phosphate isomerase deficiency.”. Baillieres Best Pract. Res. Clin. Haematol. 13 (1): 89–101. PMID 10916680.
Walker JI, Faik P, Morgan MJ (1990). „Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI).”. Genomics 7 (4): 638–43. DOI:10.1016/0888-7543(90)90212-D. PMID 2387591.
Brownstein BH, Silverman GA, Little RD, et al. (1989). „Isolation of single-copy human genes from a library of yeast artificial chromosome clones.”. Science 244 (4910): 1348–51. DOI:10.1126/science.2544027. PMID 2544027.
Mizrachi Y (1989). „Neurotrophic activity of monomeric glucophosphoisomerase was blocked by human immunodeficiency virus (HIV-1) and peptides from HIV-1 envelope glycoprotein.”. J. Neurosci. Res. 23 (2): 217–24. DOI:10.1002/jnr.490230212. PMID 2547084.
Gurney ME, Apatoff BR, Spear GT, et al. (1986). „Neuroleukin: a lymphokine product of lectin-stimulated T cells.”. Science 234 (4776): 574–81. DOI:10.1126/science.3020690. PMID 3020690.
Faik P, Walker JI, Redmill AA, Morgan MJ (1988). „Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences.”. Nature 332 (6163): 455–7. DOI:10.1038/332455a0. PMID 3352745.
Zanella A, Izzo C, Rebulla P, et al. (1981). „The first stable variant of erythrocyte glucose-phosphate isomerase associated with severe hemolytic anemia.”. Am. J. Hematol. 9 (1): 1–11. DOI:10.1002/ajh.2830090102. PMID 7435496.
Faik P, Walker JI, Morgan MJ (1994). „Identification of a novel tandemly repeated sequence present in an intron of the glucose phosphate isomerase (GPI) gene in mouse and man.”. Genomics 21 (1): 122–7. DOI:10.1006/geno.1994.1233. PMID 7545951.
Xu W, Beutler E (1995). „The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia.”. J. Clin. Invest. 94 (6): 2326–9. DOI:10.1172/JCI117597. PMC 330061. PMID 7989588.
Walker JI, Layton DM, Bellingham AJ, et al. (1993). „DNA sequence abnormalities in human glucose 6-phosphate isomerase deficiency.”. Hum. Mol. Genet. 2 (3): 327–9. DOI:10.1093/hmg/2.3.327. PMID 8499925.
Xu W, Lee P, Beutler E (1996). „Human glucose phosphate isomerase: exon mapping and gene structure.”. Genomics 29 (3): 732–9. DOI:10.1006/geno.1995.9944. PMID 8575767.
Baronciani L, Zanella A, Bianchi P, et al. (1996). „Study of the molecular defects in glucose phosphate isomerase-deficient patients affected by chronic hemolytic anemia.”. Blood 88 (6): 2306–10. PMID 8822952.
Kanno H, Fujii H, Hirono A, et al. (1996). „Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia.”. Blood 88 (6): 2321–5. PMID 8822954.
Beutler E, West C, Britton HA, et al. (1998). „Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA).”. Blood Cells Mol. Dis. 23 (3): 402–9. DOI:10.1006/bcmd.1997.0157. PMID 9446754.
Kanno H, Fujii H, Miwa S (1998). „Expression and enzymatic characterization of human glucose phosphate isomerase (GPI) variants accounting for GPI deficiency.”. Blood Cells Mol. Dis. 24 (1): 54–61. DOI:10.1006/bcmd.1998.0170. PMID 9616041.
Kugler W, Breme K, Laspe P, et al. (1998). „Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency.”. Hum. Genet. 103 (4): 450–4. DOI:10.1007/s004390050849. PMID 9856489.
Belyaeva OV, Balanovsky OP, Ashworth LK, et al. (1999). „Fine mapping of a polymorphic CA repeat marker on human chromosome 19 and its use in population studies.”. Gene 230 (2): 259–66. DOI:10.1016/S0378-1119(99)00056-6. PMID 10216265.
Yakirevich E, Naot Y (2000). „Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination.”. Biol. Reprod. 62 (4): 1016–23. DOI:10.1095/biolreprod62.4.1016. PMID 10727272.
Haga A, Niinaka Y, Raz A (2000). „Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.”. Biochim. Biophys. Acta 1480 (1-2): 235–44. PMID 11004567.