CCL24
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| Hemokin (C-C motiv) ligand 24 | |
|---|---|
| Identifikatori | |
| Simbol | CCL24 |
| Alt. simboli | SCYA24, Ckb-6, MPIF-2, eotaxin-2 |
| Entrez | 6369 |
| HUGO | 10623 |
| OMIM | 602495 |
| PDB | 1EIG |
| RefSeq | NM_002991 |
| UniProt | O00175 |
| Drugi podaci | |
| Lokus | Hromozom 7 q11.23 |
CCL24, hemokin (C-C motiv) ligand 24, takođe poznat kao mijeloidni progenitor inhibitorni faktor 2 (MPIF-2), ili eozinofilni hemotaksni protein 2 (eotaksin-2), je protein koji je kod ljudi kodiran CCL24 genom.[1] Taj gen je lociran na ljudskom hromozomu 7.[2][3]
Funkcija[uredi | uredi kod]
CCL24 je mali citokin iz CC hemokin familije. CCL24 interaguje sa hemokinskim receptorom CCR3 i indukuje hemotaksu eozinofila.[4] Ovaj hemokin je takođe snažno hemotaksan za neaktivirane T limfocite, i u manjoj meri privlači neutrofile.[1]
Klinički značaj[uredi | uredi kod]
Povišeni nivoi eotaksina-2 su promećeni kod pacijenata sa aspirin pogoršanim respiratornim bolestima, kao što je astma. Ljudi kod kojh su nivoi eotaksina-2 u plazmi niži nisu pokazivali tendenciju ka razvijanju aspirin uzrokovane astme.[5]
Reference[uredi | uredi kod]
- ↑ 1,0 1,1 Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). „Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors”. J. Exp. Med. 185 (7): 1163–72. PMC 2196270. PMID 9104803.
- ↑ Hillier LW, Fulton RS, Fulton LA, et al. (July 2003). „The DNA sequence of human chromosome 7”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
- ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
- ↑ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). „Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils”. J. Leukoc. Biol. 62 (5): 667–75. PMID 9365122.
- ↑ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). „Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease”. Allergy. DOI:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.