CCL21

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Hemokin (C-C motiv) ligand 21
Identifikatori
SimboliCCL21; 6Ckine; CKb9; ECL; MGC34555; SCYA21; SLC; TCA4
Vanjski IDOMIM602737 HomoloGene88457 GeneCards: CCL21 Gene
Pregled RNK izražavanja
PBB GE CCL21 204606 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez6366n/a
EnsemblENSG00000137077n/a
UniProtO00585n/a
RefSeq (mRNA)NM_002989n/a
RefSeq (protein)NP_002980n/a
Lokacija (UCSC)Chr 9:
34.7 - 34.7 Mb
n/a
PubMed pretraga[1]n/a

CCL21, hemokin (C-C motiv) ligand 21, je mali citokin iz CC hemokin familije. Ovaj hemokin je takođe poznat kao 6Ckine (zato što ima šest konzerviranih cisteinskih ostataka umesto četiri cisteina kao što je tipično za hemokine), exodus-2, i sekondarni hemokin limfoidnog-tkiva (SLC).[1][2][3] Gen za CCL21 je lociran na ljudskom hromozom 9. CCL21 dejstvuje putem vezivanja za hemokinski receptor na ćelijskoj površini pod imenom CCR7.[4][5]

Reference[uredi - уреди | uredi izvor]

  1. Hedrick JA, Zlotnik A (1997). "Identification and characterization of a novel beta chemokine containing six conserved cysteines". J. Immunol. 159 (4): 1589–93. PMID 9257816. 
  2. Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (1997). "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension". J. Immunol. 159 (6): 2554–8. PMID 9300671. 
  3. Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". J. Biol. Chem. 272 (31): 19518–24. PMID 9235955. doi:10.1074/jbc.272.31.19518. 
  4. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O (1998). "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7". J. Biol. Chem. 273 (12): 7118–22. PMID 9507024. doi:10.1074/jbc.273.12.7118. 
  5. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 

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