Interleukin 11

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Interleukin 11
Identifikatori
SimboliIL11; AGIF; IL-11
Vanjski IDOMIM147681 MGI107613 HomoloGene535 GeneCards: IL11 Gene
Pregled RNK izražavanja
PBB GE IL11 206926 s at tn.png
PBB GE IL11 206924 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez358916156
EnsemblENSG00000095752ENSMUSG00000004371
UniProtP20809Q3V0U3
Ref. Sekv. (iRNK)NM_000641NM_008350
Ref. Sekv. (protein)NP_000632NP_032376
Lokacija (UCSC)Chr 19:
60.57 - 60.57 Mb
Chr 7:
4.38 - 4.38 Mb
PubMed pretraga[1][2]

Interleukin 11 (IL-11) je protein koji je kod ljudi kodiran IL11 genom.[1][2]

IL-11 je multifunkcionalni citokin koji je prvo izolovan 1990. godine iz kičmene moždine-izvedenih stromalnih ćelija. On je ključni regulator of više evenata hematopoeze, pogotovu stimulacije sazrevanja megakariocita.[3] On je isto poznat pod imenima inhibitorni faktor adipogeneze (AGIF)[4] i oprelvekin.

U poređenju sa drugim interleukinima, IL-11 je relativno slabo karakterisan.

Struktura[uredi - уреди | uredi izvor]

LJudski IL-11 gen, koji sadrži 5 eksona i 4 introna, je lociran na hromozomu 19,[1] i kodira 23 kDa protein. IL-11 is je član IL-6 citokinske familije, koja je osobena po upotrebi zajedničkog koreceptora gp130. Signal specifičnost daje IL-11R alfa podjedinica.

Signalizacija[uredi - уреди | uredi izvor]

Prenos signala se inicira nakon IL-11 vezivanja za IL-11R alfa i gp130, što omogućava homodimerizaciju gp130 molekula. Ovo omogućava gp130-asociranoj JAK kinazi da se aktivira i da fosforiliše intracelularne tirozinove ostatke na gp130.[5][6]

Funkcija[uredi - уреди | uredi izvor]

Za IL-11 je bilo pokazano da poboljšava oporavak trombocita nakon hemoterapijom-uzrokovane trombocitopenije, inducira akutnu fazu proteina, modulira antigen-antitelo odziv, učestvuje u regulaciji proliferacije i diferencijacije koštanih ćelija, i možda može biti korišćen kao terapeutik za osteoporozu. IL-11 stimuliše rast određenih limfocita, i u modelu na glodarima, stimuliše povećanje kortikalne debljine i jačanje dugačkih kostiju. Pored toga što ima limfopoetske/hematopoetske i osteotrofske osobine, on funkcioniše u mnogim drugim tkivima, uključujući mozak, creva i testise.

Reference[uredi - уреди | uredi izvor]

  1. 1,0 1,1 McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). "Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)". Genomics 13 (3): 814–9. PMID 1386338. doi:10.1016/0888-7543(92)90158-O. 
  2. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 
  3. Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM, Leary AC, Sibley B, Clark SC, Williams DA (1990). "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512–6. PMID 2145578. doi:10.1073/pnas.87.19.7512. 
  4. Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y (1991). "Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11". FEBS Lett. 283 (2): 199–202. PMID 1828438. doi:10.1016/0014-5793(91)80587-S. 
  5. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F (August 2003). "Principles of interleukin (IL)-6-type cytokine signalling and its regulation". Biochem. J. 374 (Pt 1): 1–20. PMC 1223585. PMID 12773095. doi:10.1042/BJ20030407. 
  6. Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4. http://bcs.whfreeman.com/immunology6e/default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0. 

Literatura[uredi - уреди | uredi izvor]

  • Yang YC, Yin T (1993). "Interleukin-11 and its receptor.". Biofactors 4 (1): 15–21. PMID 1292471. 
  • Bhatia M, Davenport V, Cairo MS (2007). "The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes.". Leuk. Lymphoma 48 (1): 9–15. PMID 17325843. doi:10.1080/10428190600909115. 
  • McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). "Genomic sequence and chromosomal location of human interleukin-11 gene (IL11).". Genomics 13 (3): 814–9. PMID 1386338. doi:10.1016/0888-7543(92)90158-O. 
  • Kawashima I, Ohsumi J, Mita-Honjo K et al. (1991). "Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.". FEBS Lett. 283 (2): 199–202. PMID 1828438. doi:10.1016/0014-5793(91)80587-S. 
  • Paul SR, Bennett F, Calvetti JA et al. (1990). "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512–6. PMID 2145578. doi:10.1073/pnas.87.19.7512. 
  • Wang XY, Fuhrer DK, Marshall MS, Yang YC (1996). "Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.". J. Biol. Chem. 270 (47): 27999–8002. PMID 7499280. 
  • Chérel M, Sorel M, Lebeau B et al. (1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11.". Blood 86 (7): 2534–40. PMID 7670098. 
  • Yamaguchi M, Miki N, Ono M et al. (1995). "Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer.". Endocrinology 136 (3): 1072–8. PMID 7867561. doi:10.1210/en.136.3.1072. 
  • Mehler MF, Rozental R, Dougherty M et al. (1993). "Cytokine regulation of neuronal differentiation of hippocampal progenitor cells.". Nature 362 (6415): 62–5. PMID 8383296. doi:10.1038/362062a0. 
  • Morris JC, Neben S, Bennett F et al. (1996). "Molecular cloning and characterization of murine interleukin-11.". Exp. Hematol. 24 (12): 1369–76. PMID 8913282. 
  • Neddermann P, Graziani R, Ciliberto G, Paonessa G (1997). "Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130.". J. Biol. Chem. 271 (48): 30986–91. PMID 8940087. doi:10.1074/jbc.271.48.30986. 
  • Barton VA, Hudson KR, Heath JK (1999). "Identification of three distinct receptor binding sites of murine interleukin-11.". J. Biol. Chem. 274 (9): 5755–61. PMID 10026196. doi:10.1074/jbc.274.9.5755. 
  • Tacken I, Dahmen H, Boisteau O et al. (1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.". Eur. J. Biochem. 265 (2): 645–55. PMID 10504396. doi:10.1046/j.1432-1327.1999.00755.x. 
  • Mahboubi K, Biedermann BC, Carroll JM, Pober JS (2000). "IL-11 activates human endothelial cells to resist immune-mediated injury.". J. Immunol. 164 (7): 3837–46. PMID 10725745. 
  • Barton VA, Hall MA, Hudson KR, Heath JK (2000). "Interleukin-11 signals through the formation of a hexameric receptor complex.". J. Biol. Chem. 275 (46): 36197–203. PMID 10948192. doi:10.1074/jbc.M004648200. 
  • Curti A, Tafuri A, Ricciardi MR et al. (2002). "Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1).". Haematologica 87 (4): 373–80. PMID 11940481. 
  • Van der Meeren A, Mouthon MA, Gaugler MH et al. (2002). "Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin.". Radiat. Res. 157 (6): 642–9. PMID 12005542. doi:10.1667/0033-7587(2002)157[0642:AORHIA]2.0.CO;2. 
  • McCloy MP, Roberts IA, Howarth LJ et al. (2002). "Interleukin-11 levels in healthy and thrombocytopenic neonates.". Pediatr. Res. 51 (6): 756–60. PMID 12032273. 
  • Bartz H, Büning-Pfaue F, Türkel O, Schauer U (2002). "Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells.". Clin. Exp. Immunol. 129 (3): 438–45. PMID 12197884. doi:10.1046/j.1365-2249.2002.01927.x. 

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