CCL4

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Hemokin (C-C motiv) ligand 4

PDB prikaz baziran na 1hum.
Dostupne strukture
1hum, 1hun, 1je4, 2ffk, 2fin
Identifikatori
SimboliCCL4; SCYA4; ACT2; AT744.1; G-26; LAG1; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP1B
Vanjski IDOMIM182284 MGI98261 HomoloGene48153 GeneCards: CCL4 Gene
Pregled RNK izražavanja
PBB GE CCL4 204103 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez635120303
EnsemblENSG00000129277ENSMUSG00000018930
UniProtP13236Q5QNV9
RefSeq (mRNA)NM_002984NM_013652
RefSeq (protein)NP_002975NP_038680
Lokacija (UCSC)Chr 17:
31.46 - 31.46 Mb
Chr 11:
83.48 - 83.48 Mb
PubMed pretraga[1][2]

CCL4, hemokin (C-C motiv) ligand 4, je protein koji je kod ljudi kodiran CCL4 genom.[1][2]

Funkcija[uredi - уреди | uredi izvor]

CCL4 je CC chemokin koji je specifičan za CCR5 receptore. On je hemoatraktant za NK ćelije, monocite i niz drugih imunskih ćelija.[3]

CCL4 je značajan HIV-supresujući faktor koji proizvode CD8+ T ćelije.[4] Perforin memorijske CD8+ T ćelije normalno sintetišu MIP-1-beta.[5]

Interakcije[uredi - уреди | uredi izvor]

Za CCL4 je bilo pokazano da interaguje sa CCL3.[6]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. PMC 330932. PMID 1972563. doi:10.1093/nar/18.11.3261. 
  2. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 
  3. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nat. Immunol. 2 (12): 1126–32. PMID 11702067. doi:10.1038/ni735. 
  4. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science (journal) 270 (5243): 1811–5. PMID 8525373. 
  5. Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9283–8. PMC 55412. PMID 11470920. doi:10.1073/pnas.161298998. 
  6. Guan, E; Wang J, Norcross M A (April 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". J. Biol. Chem. (United States) 276 (15): 12404–9. ISSN 0021-9258. PMID 11278300. doi:10.1074/jbc.M006327200. 

Literatura[uredi - уреди | uredi izvor]

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  • Muthumani K, Desai BM, Hwang DS et al. (2004). "HIV-1 Vpr and anti-inflammatory activity.". DNA Cell Biol. 23 (4): 239–47. PMID 15142381. doi:10.1089/104454904773819824. 
  • Conti L, Fantuzzi L, Del Cornò M et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1-2): 99–115. PMID 15481145. doi:10.1016/j.imbio.2004.02.008. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013. 
  • Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143–9. PMID 15780175. doi:10.1038/sj.cr.7290279. 
  • Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944. 
  • Li L, Li HS, Pauza CD et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11-12): 923–34. PMID 16354571. doi:10.1038/sj.cr.7290370. 
  • King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity.". Microbes Infect. 8 (5): 1347–57. PMID 16697675. doi:10.1016/j.micinf.2005.11.014. 
  • Napolitano M, Modi WS, Cevario SJ et al. (1991). "The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization.". J. Biol. Chem. 266 (26): 17531–6. PMID 1894635. 
  • Irving SG, Zipfel PF, Balke J et al. (1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q.". Nucleic Acids Res. 18 (11): 3261–70. PMC 330932. PMID 1972563. doi:10.1093/nar/18.11.3261. 
  • Baixeras E, Roman-Roman S, Jitsukawa S et al. (1991). "Cloning and expression of a lymphocyte activation gene (LAG-1).". Mol. Immunol. 27 (11): 1091–102. PMID 2247088. doi:10.1016/0161-5890(90)90097-J. 
  • Lipes MA, Napolitano M, Jeang KT et al. (1989). "Identification, cloning, and characterization of an immune activation gene.". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9704–8. PMC 282843. PMID 2462251. doi:10.1073/pnas.85.24.9704. 
  • Brown KD, Zurawski SM, Mosmann TR, Zurawski G (1989). "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.". J. Immunol. 142 (2): 679–87. PMID 2521353. 
  • Zipfel PF, Balke J, Irving SG et al. (1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.". J. Immunol. 142 (5): 1582–90. PMID 2521882. 
  • Chang HC, Reinherz EL (1989). "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes.". Eur. J. Immunol. 19 (6): 1045–51. PMID 2568930. doi:10.1002/eji.1830190614. 
  • Miller MD, Hata S, De Waal Malefyt R, Krangel MS (1989). "A novel polypeptide secreted by activated human T lymphocytes.". J. Immunol. 143 (9): 2907–16. PMID 2809212. 
  • Adams MD, Kerlavage AR, Fleischmann RD et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098. 
  • Post TW, Bozic CR, Rothenberg ME et al. (1995). "Molecular characterization of two murine eosinophil beta chemokine receptors.". J. Immunol. 155 (11): 5299–305. PMID 7594543. 
  • Combadiere C, Ahuja SK, Murphy PM (1995). "Cloning and functional expression of a human eosinophil CC chemokine receptor.". J. Biol. Chem. 270 (28): 16491–4. PMID 7622448. doi:10.1074/jbc.270.28.16491. 
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