Interleukin 16

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Interleukin 16 (limfocit hemoatraktant faktor)

PDB prikaz baziran na 1i16.
Dostupne strukture
1i16, 1x6d
Identifikatori
SimboliIL16; FLJ16806; FLJ42735; FLJ44234; HsT19289; IL-16; LCF; prIL-16
Vanjski IDOMIM603035 MGI1270855 HomoloGene18157 GeneCards: IL16 Gene
Pregled RNK izražavanja
PBB GE IL16 209827 s at tn.png
PBB GE IL16 209828 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez360316170
EnsemblENSG00000172349ENSMUSG00000001741
UniProtQ14005Q3UZ81
Ref. Sekv. (iRNK)NM_004513NM_010551
Ref. Sekv. (protein)NP_004504NP_034681
Lokacija (UCSC)Chr 15:
79.26 - 79.39 Mb
Chr 7:
83.52 - 83.61 Mb
PubMed pretraga[1][2]

Prointerleukin 16 je protein koji je kod ljudi kodiran IL16 genom.[1][2] Ovaj gen su otkrili 1982. godine Dr. David Center i Dr. William Cruikshank sa Bostonskog univerziteta.[3][4]

Protein kodiran ovim genom je pliotropski citokin koji funkcioniše kao hemoatraktant, modulator aktivacije T ćelija, i inhibitor HIV replikacije. Signalni prenos ovog citokin posreduje CD4. Proizvod ovog gena se podvrgava proteolitičkoj obradi, za koju je nađeno da proizvodi dva funkcionalna proteina. Citokinska funkcija se isključivo pripisuje izlučenom C-terminalnom peptidu, dok N-terminalni proizvod možda igra ulogu u kontroli đelijskog ciklusa. Za kaspazu 3 se zna da učestvuje u proteolitičkoj obradi ovog proteina. Dve alternativno splajsovane transkripcione varijante koje kodiraju dve različite izoforme su bile objavljene.[2]

Interleukin 16 (IL-16) je citokin koga oslobađaju mnoge vrste ćelija (uključujući limfocite i neke od epitelijalnih ćelija). On je karakterisan kao hemoatraktant za određene imune ćelije koje izražavaju na ćelijskoj površini molekul CD4.[5]

IL-16 je bio originalno opisan kao faktor koje može da privuče T ćelije kod ljudi, i on se ranije zvao limfocit hemoatraktant faktor (LCF).[3] Od tog vremena, za ovaj interleukin je bilo pokazano da može da regrutuje mnoge druge ćelije koje izražavaju CD4 molekul, uključujući monocite, eosinofile, i dendritske ćelije.[6]

Struktura[uredi - уреди | uredi izvor]

IL-16 struktura je bila određena nakon kloniranja 1994. godine.[7] Ovoj citokin se proizvodi kao prekusor peptida (pro-IL-16) koji se mora skratiti enzimom kaspaza-3 da bi se aktivirao. CD4 je signalizacioni receptor za IL-16.

Interakcije[uredi - уреди | uredi izvor]

Za interleukin 16 pokazano da formira interakcije sa Kir2.1,[8] KCNJ10,[8] GRIN2D,[8] GRIN2A,[8] PPP1R12B,[9] PPP1R12A[9] and KCNJ15.[8]

Reference[uredi - уреди | uredi izvor]

  1. Baier M, Bannert N, Werner A, Lang K, Kurth R (Jun 1997). "Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor". Proc Natl Acad Sci U S A 94 (10): 5273–7. PMC 24668. PMID 9144227.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3603. 
  3. 3,0 3,1 Cruikshank W, Center DM (1982). "Modulation of lymphocyte migration by human lymphokines. II. Purification of a lymphotactic factor (LCF)". J. Immunol. 128 (6): 2569–74. PMID 7042841. 
  4. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 
  5. Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4. http://bcs.whfreeman.com/immunology6e/default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0. 
  6. Cruikshank WW, Kornfeld H, Center DM (2000). "Interleukin-16". J. Leukoc. Biol. 67 (6): 757–66. PMID 10857846. 
  7. Cruikshank WW, Center DM, Nisar N, Wu M, Natke B, Theodore AC, Kornfeld H (1994). "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5109–13. PMID 7910967. doi:10.1073/pnas.91.11.5109. 
  8. 8,0 8,1 8,2 8,3 8,4 Kurschner, C; Yuzaki M (September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. (UNITED STATES) 19 (18): 7770–80. PMID 10479680. 
  9. 9,0 9,1 Bannert, Norbert; Vollhardt Karin, Asomuddinov Bakhtier, Haag Marion, König Herbert, Norley Stephen, Kurth Reinhard (October 2003). "PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits". J. Biol. Chem. (United States) 278 (43): 42190–9. ISSN 0021-9258. PMID 12923170. doi:10.1074/jbc.M306669200. 

Literatura[uredi - уреди | uredi izvor]

  • Wilson KC, Center DM, Cruikshank WW (2005). "The effect of interleukin-16 and its precursor on T lymphocyte activation and growth.". Growth Factors 22 (2): 97–104. PMID 15253385. doi:10.1080/08977190410001704679. 
  • Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093–101. PMID 16375755. doi:10.2174/138955705774933383. 
  • Rand TH, Cruikshank WW, Center DM, Weller PF (1991). "CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration.". J. Exp. Med. 173 (6): 1521–8. PMID 1851800. doi:10.1084/jem.173.6.1521. 
  • Ryan TC, Cruikshank WW, Kornfeld H et al. (1995). "The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration.". J. Biol. Chem. 270 (29): 17081–6. PMID 7615501. doi:10.1074/jbc.270.29.17081. 
  • Cruikshank WW, Center DM, Nisar N et al. (1994). "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5109–13. PMID 7910967. doi:10.1073/pnas.91.11.5109. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Parada NA, Cruikshank WW, Danis HL et al. (1996). "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.". Cell. Immunol. 168 (1): 100–6. PMID 8599832. doi:10.1006/cimm.1996.0054. 
  • Bannert N, Baier M, Werner A, Kurth R (1996). "Interleukin-16 or not?". Nature 381 (6577): 30. PMID 8609984. doi:10.1038/381030a0. 
  • Maciaszek JW, Parada NA, Cruikshank WW et al. (1997). "IL-16 represses HIV-1 promoter activity.". J. Immunol. 158 (1): 5–8. PMID 8977168. 
  • Laberge S, Ernst P, Ghaffar O et al. (1997). "Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma.". Am. J. Respir. Cell Mol. Biol. 17 (2): 193–202. PMID 9271307. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
  • Zhang Y, Center DM, Wu DM et al. (1998). "Processing and activation of pro-interleukin-16 by caspase-3.". J. Biol. Chem. 273 (2): 1144–9. PMID 9422780. doi:10.1074/jbc.273.2.1144. 
  • Mühlhahn P, Zweckstetter M, Georgescu J et al. (1998). "Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site.". Nat. Struct. Biol. 5 (8): 682–6. PMID 9699630. doi:10.1038/1376. 
  • Chupp GL, Wright EA, Wu D et al. (1998). "Tissue and T cell distribution of precursor and mature IL-16.". J. Immunol. 161 (6): 3114–9. PMID 9743378. 
  • Bannert N, Avots A, Baier M et al. (1999). "GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1541–6. PMID 9990060. doi:10.1073/pnas.96.4.1541. 
  • Kim HS (1999). "Assignment of human interleukin 16 (IL16) to chromosome 15q26.3 by radiation hybrid mapping.". Cytogenet. Cell Genet. 84 (1-2): 93. PMID 10343113. doi:10.1159/000015224. 
  • Liu Y, Cruikshank WW, O'Loughlin T et al. (1999). "Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation.". J. Biol. Chem. 274 (33): 23387–95. PMID 10438516. doi:10.1074/jbc.274.33.23387. 
  • Kaser A, Dunzendorfer S, Offner FA et al. (1999). "A role for IL-16 in the cross-talk between dendritic cells and T cells.". J. Immunol. 163 (6): 3232–8. PMID 10477592. 
  • Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.". J. Neurosci. 19 (18): 7770–80. PMID 10479680. 

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