CXCL3
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| Hemokine (C-X-C motif) ligand 3 | |
|---|---|
| Identifikatori | |
| Simbol | CXCL3 |
| Alt. simboli | SCYB3, GRO3, GROg, MIP-2b, CINC-2b |
| Entrez | 2921 |
| HUGO | 4604 |
| OMIM | 139111 |
| RefSeq | NM_002090 |
| UniProt | P19876 |
| Drugi podaci | |
| Lokus | Hromozom 4 q21 |
CXCL3, hemokin (C-X-C motiv) ligand 3, je mali citokin iz CXC hemokin familije koji je poznat kao GRO3 onkogen (GRO3), GRO protein gama (GROg) i makrofagni inflamatorni protein-2-beta (MIP2b). CXCL3 kontroliše migraciju i adheziju monocit. Ovaj hemokin ostvaruje efekte na svojim ciljnim ćelijama putem interakcije sa hemokin receptorom na ćelijskoj površini koji se zove CXCR2.[1][2] CXCL3 gen je lociran na hromozomu 4 u klusteru sa drugim CXC hemokinima.[3][4]
Reference[uredi | uredi kod]
- ↑ Smith DF, Galkina E, Ley K, Huo Y. GRO family chemokines are specialized for monocyte arrest from flow. Am J Physiol Heart Circ Physiol. 2005, 289(5):H1976-84. PMID: 15937099
- ↑ Ahuja SK, Murphy PM. The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. J Biol Chem. 1996, 23;271(34):20545-50. PMID: 8702798
- ↑ O'Donovan, N., Galvin, M. Morgan, J.G. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999. PMID: 10343098
- ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.