CCL11

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Hemokin (C-C motiv) ligand 11

PDB prikaz baziran na 1eot.
Dostupne strukture
1eot, 2eot
Identifikatori
SimboliCCL11; MGC22554; SCYA11
Vanjski IDOMIM601156 MGI103576 HomoloGene7929 GeneCards: CCL11 Gene
Pregled RNK izražavanja
PBB GE CCL11 210133 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez635620292
EnsemblENSG00000172156ENSMUSG00000020676
UniProtP51671Q5SVB5
RefSeq (mRNA)NM_002986NM_011330
RefSeq (protein)NP_002977NP_035460
Lokacija (UCSC)Chr 17:
29.64 - 29.64 Mb
Chr 11:
81.87 - 81.88 Mb
PubMed pretraga[1][2]

CCL11, hemokin (C-C motiv) ligand 11, je mali citokin iz CC hemokin familije. On je takođe poznat kao eotaksin-1. CCL11 selektivno regrutuje eozinofile putem indukovanja njihove hemotakse, i zato je impliciran u alergijske response.[1][2][3]

Efekti CCL11 su posredovani njegovim vezivanjem za G-protein spregnuti hemokin receptor. Hemokin receptori CCL11 liganda su CCR2[4], CCR3[5] i CCR5.[4] Međutim, bilo je ustanovljeno da eotaksin-1 (CCL11) ima visok stepen selektivnosti za CCR3 receptor, tako da je neaktivan na neutrofilima i monocitima, koji ne izražavaju CCR3.[6] Gen ljudskog CCL11 (SCYA11) je kodiran sa tri eksona i lociran je na hromozomu 17.[7][5]

Reference[uredi - уреди | uredi kôd]

  1. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (1996). „Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils”. J. Clin. Invest. 97 (3): 604–12. DOI:10.1172/JCI118456. PMC 507095. PMID 8609214. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8609214. 
  2. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996). „Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia”. Nat. Med. 2 (4): 449–56. DOI:10.1038/nm0496-449. PMID 8597956. 
  3. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 
  4. 4,0 4,1 Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (2001). „Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5”. Blood 97 (7): 1920–4. DOI:10.1182/blood.V97.7.1920. PMID 11264152. 
  5. 5,0 5,1 Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (1996). „Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3”. J. Biol. Chem. 271 (13): 7725–30. DOI:10.1074/jbc.271.13.7725. PMID 8631813. 
  6. Baggiolini M, Dewald B, Moser B (1997). „Human chemokines: an update”. Annu. Rev. Immunol. 15: 675–705. DOI:10.1146/annurev.immunol.15.1.675. PMID 9143704. 
  7. Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (1997). „Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene”. Biochem. Biophys. Res. Commun. 237 (3): 537–42. DOI:10.1006/bbrc.1997.7169. PMID 9299399. 

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