CCL11

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Hemokin (C-C motiv) ligand 11

PDB prikaz baziran na 1eot.
Dostupne strukture
1eot, 2eot
Identifikatori
Simboli CCL11; MGC22554; SCYA11
Vanjski ID OMIM601156 MGI103576 HomoloGene7929 GeneCards: CCL11 Gene
Pregled RNK izražavanja
PBB GE CCL11 210133 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6356 20292
Ensembl ENSG00000172156 ENSMUSG00000020676
UniProt P51671 Q5SVB5
RefSeq (mRNA) NM_002986 NM_011330
RefSeq (protein) NP_002977 NP_035460
Lokacija (UCSC) Chr 17:
29.64 - 29.64 Mb
Chr 11:
81.87 - 81.88 Mb
PubMed pretraga [1] [2]

CCL11, hemokin (C-C motiv) ligand 11, je mali citokin iz CC hemokin familije. On je takođe poznat kao eotaksin-1. CCL11 selektivno regrutuje eozinofile putem indukovanja njihove hemotakse, i zato je impliciran u alergijske response.[1][2][3]

Efekti CCL11 su posredovani njegovim vezivanjem za G-protein spregnuti hemokin receptor. Hemokin receptori CCL11 liganda su CCR2[4], CCR3[5] i CCR5.[4] Međutim, bilo je ustanovljeno da eotaksin-1 (CCL11) ima visok stepen selektivnosti za CCR3 receptor, tako da je neaktivan na neutrofilima i monocitima, koji ne izražavaju CCR3.[6] Gen ljudskog CCL11 (SCYA11) je kodiran sa tri eksona i lociran je na hromozomu 17.[7][5]

Reference[uredi - уреди | uredi izvor]

  1. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". J. Clin. Invest. 97 (3): 604–12. PMC 507095. PMID 8609214. doi:10.1172/JCI118456. 
  2. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nat. Med. 2 (4): 449–56. PMID 8597956. doi:10.1038/nm0496-449. 
  3. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 
  4. 4,0 4,1 Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (2001). "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5". Blood 97 (7): 1920–4. PMID 11264152. doi:10.1182/blood.V97.7.1920. 
  5. 5,0 5,1 Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". J. Biol. Chem. 271 (13): 7725–30. PMID 8631813. doi:10.1074/jbc.271.13.7725. 
  6. Baggiolini M, Dewald B, Moser B (1997). "Human chemokines: an update". Annu. Rev. Immunol. 15: 675–705. PMID 9143704. doi:10.1146/annurev.immunol.15.1.675. 
  7. Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochem. Biophys. Res. Commun. 237 (3): 537–42. PMID 9299399. doi:10.1006/bbrc.1997.7169. 

Literatura[uredi - уреди | uredi izvor]

  • Garcia-Zepeda EA, Rothenberg ME, Ownbey RT et al. (1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.". Nat. Med. 2 (4): 449–56. PMID 8597956. doi:10.1038/nm0496-449. 
  • Ponath PD, Qin S, Ringler DJ et al. (1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.". J. Clin. Invest. 97 (3): 604–12. PMC 507095. PMID 8609214. doi:10.1172/JCI118456. 
  • Kitaura M, Nakajima T, Imai T et al. (1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.". J. Biol. Chem. 271 (13): 7725–30. PMID 8631813. doi:10.1074/jbc.271.13.7725. 
  • Daugherty BL, Siciliano SJ, DeMartino JA et al. (1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor.". J. Exp. Med. 183 (5): 2349–54. PMC 2192548. PMID 8642344. doi:10.1084/jem.183.5.2349. 
  • Choe H, Farzan M, Sun Y et al. (1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.". Cell 85 (7): 1135–48. PMID 8674119. doi:10.1016/S0092-8674(00)81313-6. 
  • Ponath PD, Qin S, Post TW et al. (1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.". J. Exp. Med. 183 (6): 2437–48. PMC 2192612. PMID 8676064. doi:10.1084/jem.183.6.2437. 
  • Bartels J, Schlüter C, Richter E et al. (1996). "Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.". Biochem. Biophys. Res. Commun. 225 (3): 1045–51. PMID 8780731. doi:10.1006/bbrc.1996.1292. 
  • Garcia-Zepeda EA, Rothenberg ME, Weremowicz S et al. (1997). "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.". Genomics 41 (3): 471–6. PMID 9169149. doi:10.1006/geno.1997.4656. 
  • Hein H, Schlüter C, Kulke R et al. (1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.". Biochem. Biophys. Res. Commun. 237 (3): 537–42. PMID 9299399. doi:10.1006/bbrc.1997.7169. 
  • Nibbs RJ, Wylie SM, Yang J et al. (1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.". J. Biol. Chem. 272 (51): 32078–83. PMID 9405404. doi:10.1074/jbc.272.51.32078. 
  • Rubbert A, Combadiere C, Ostrowski M et al. (1998). "Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.". J. Immunol. 160 (8): 3933–41. PMID 9558100. 
  • Noso N, Bartels J, Mallet AI et al. (1998). "Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.". Eur. J. Biochem. 253 (1): 114–22. PMID 9578468. doi:10.1046/j.1432-1327.1998.2530114.x. 
  • Crump MP, Rajarathnam K, Kim KS et al. (1998). "Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.". J. Biol. Chem. 273 (35): 22471–9. PMID 9712872. doi:10.1074/jbc.273.35.22471. 
  • Sabroe I, Hartnell A, Jopling LA et al. (1999). "Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.". J. Immunol. 162 (5): 2946–55. PMID 10072545. 
  • Jinquan T, Quan S, Feili G et al. (1999). "Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4.". J. Immunol. 162 (7): 4285–92. PMID 10201960. 
  • Klein RS, Williams KC, Alvarez-Hernandez X et al. (1999). "Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.". J. Immunol. 163 (3): 1636–46. PMID 10415069. 
  • Blanpain C, Migeotte I, Lee B et al. (1999). "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.". Blood 94 (6): 1899–905. PMID 10477718. 
  • Zhang J, Lathbury LJ, Salamonsen LA (2000). "Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium.". Biol. Reprod. 62 (2): 404–11. PMID 10642580. doi:10.1095/biolreprod62.2.404. 
  • Kampen GT, Stafford S, Adachi T et al. (2000). "Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.". Blood 95 (6): 1911–7. PMID 10706854. 
  • Huber MA, Kraut N, Addicks T, Peter RU (2000). "Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation.". Biochem. Biophys. Res. Commun. 269 (2): 546–52. PMID 10708591. doi:10.1006/bbrc.2000.2287. 

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