Interleukin 12B

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Interleukin 12B (stimulacioni faktor 2 prirodnih ubica ćelija, faktor sazrevanja 2 citotoksičnih limfocita, p40)

PDB prikaz baziran na 1f42.
Dostupne strukture
1f42, 1f45
Identifikatori
SimboliIL12B; CLMF; CLMF2; IL-12B; NKSF; NKSF2
Vanjski IDOMIM161561 MGI96540 HomoloGene1648 GeneCards: IL12B Gene
Pregled RNK izražavanja
PBB GE IL12B 207901 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez359316160
EnsemblENSG00000113302ENSMUSG00000004296
UniProtP29460Q3ZAX5
Ref. Sekv. (iRNK)NM_002187NM_008352
Ref. Sekv. (protein)NP_002178NP_032378
Lokacija (UCSC)Chr 5:
158.67 - 158.69 Mb
Chr 11:
44.24 - 44.26 Mb
PubMed pretraga[1][2]

Interleukin 12 podjedinica beta (isto poznat kao stimulacioni faktor 2 prirodnih ubica ćelija, ili faktor sazrevanja 2 citotoksičnih limfocita, p40) (ljudski gen IL12B) je podjedinica ljudskog interleukina 12.

Ovaj gen kodira podjedinicu interleukina 12, citokina koji dejstvuje na T i prirodni ubica ćelijama, i ima dugačak niz bioloških aktivnosti. Interleukin 12 je disulfidno-vezan heterodimer koji se sastoji od 40 kD podjedinice koja je slična citokin receptoru i kodirana ovim genom, i 35 kD podjedinice kodirane IL12A genom. Ovaj citokin je izražen u aktiviranim makrofagama koje služe kao esencijalni pobuđivač razvoja Th1 ćelija.[1] Za ovaj citokin je nađeno da je važan za održavanje dovoljnog broja memorijskih/efektorskih Th1 ćelija čime posreduje dugoročnu zaštitu od intracelularnih patogena. Pre-izražavanje ovog gena je primećeno u centralnom nervnom sistemu pacijenata sa multiplom sklerozom (MS), što sugerira da ovaj citokin igra ulogu u patogenezi bolesti. Promotor gen polimorfizam ovog gena se zna da je asociran sa ozbiljnošću astme kod dece.[2][3]

Interakcije[uredi - уреди | uredi izvor]

Interleukin-12 podjedinica beta je pokazan da ostvaruje interakciju sa interleukinom 23.[4]

Reference[uredi - уреди | uredi izvor]

  1. Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4. http://bcs.whfreeman.com/immunology6e/default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0. 
  2. "Entrez Gene: IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3593. 
  3. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. http://www.sciencedirect.com/science/book/9780124983403. 
  4. Oppmann, B; Lesley R, Blom B, Timans J C, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams J S, Moore K W, Rennick D, de Waal-Malefyt R, Hannum C, Bazan J F, Kastelein R A (November 2000). "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12". Immunity (UNITED STATES) 13 (5): 715–25. ISSN 1074-7613. PMID 11114383. 

Literatura[uredi - уреди | uredi izvor]

  • Airoldi I, Guglielmino R, Carra G et al. (2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes.". Haematologica 87 (4): 434–42. PMID 11940489. 
  • Abdi K (2002). "IL-12: the role of p40 versus p75.". Scand. J. Immunol. 56 (1): 1–11. PMID 12100467. doi:10.1046/j.1365-3083.2002.01101.x. 
  • Sieburth D, Jabs EW, Warrington JA et al. (1992). "Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.". Genomics 14 (1): 59–62. PMID 1358798. doi:10.1016/S0888-7543(05)80283-6. 
  • Wolf SF, Temple PA, Kobayashi M et al. (1991). "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.". J. Immunol. 146 (9): 3074–81. PMID 1673147. 
  • Gubler U, Chua AO, Schoenhaut DS et al. (1991). "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4143–7. PMID 1674604. doi:10.1073/pnas.88.10.4143. 
  • Gearing DP, Cosman D (1991). "Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor.". Cell 66 (1): 9–10. PMID 2070420. doi:10.1016/0092-8674(91)90131-H. 
  • Stern AS, Podlaski FJ, Hulmes JD et al. (1990). "Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.". Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6808–12. PMID 2204066. doi:10.1073/pnas.87.17.6808. 
  • Aragane Y, Riemann H, Bhardwaj RS et al. (1995). "IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines.". J. Immunol. 153 (12): 5366–72. PMID 7527439. 
  • Ling P, Gately MK, Gubler U et al. (1995). "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.". J. Immunol. 154 (1): 116–27. PMID 7527811. 
  • Murphy TL, Cleveland MG, Kulesza P et al. (1995). "Regulation of interleukin 12 p40 expression through an NF-kappa B half-site.". Mol. Cell. Biol. 15 (10): 5258–67. PMID 7565674. 
  • Sharma V, Knobloch TJ, Benjamin D (1995). "Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines.". Biochem. Biophys. Res. Commun. 208 (2): 704–13. PMID 7695626. doi:10.1006/bbrc.1995.1395. 
  • Warrington JA, Bengtsson U (1995). "High-resolution physical mapping of human 5q31-q33 using three methods: radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresis.". Genomics 24 (2): 395–8. PMID 7698768. doi:10.1006/geno.1994.1636. 
  • D'Andrea A, Ma X, Aste-Amezaga M et al. (1995). "Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.". J. Exp. Med. 181 (2): 537–46. PMID 7836910. doi:10.1084/jem.181.2.537. 
  • Gillessen S, Carvajal D, Ling P et al. (1995). "Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist.". Eur. J. Immunol. 25 (1): 200–6. PMID 7843232. doi:10.1002/eji.1830250133. 
  • Radrizzani M, Accornero P, Amidei A et al. (1995). "IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.". Cell. Immunol. 161 (1): 14–21. PMID 7867080. doi:10.1006/cimm.1995.1003. 
  • Ma X, Chow JM, Gri G et al. (1996). "The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.". J. Exp. Med. 183 (1): 147–57. PMID 8551218. doi:10.1084/jem.183.1.147. 
  • Fantuzzi L, Gessani S, Borghi P et al. (1996). "Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion.". J. Virol. 70 (6): 4121–4. PMID 8648753. 
  • Cella M, Scheidegger D, Palmer-Lehmann K et al. (1996). "Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.". J. Exp. Med. 184 (2): 747–52. PMID 8760829. doi:10.1084/jem.184.2.747. 
  • Kato K, Shimozato O, Hoshi K et al. (1996). "Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection.". Proc. Natl. Acad. Sci. U.S.A. 93 (17): 9085–9. PMID 8799158. doi:10.1073/pnas.93.17.9085. 
  • Taoufik Y, Lantz O, Wallon C et al. (1997). "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect.". Blood 89 (8): 2842–8. PMID 9108403. 

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