14-Cinamoiloksikodeinon

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14-Cinamoiloksikodeinon
(IUPAC) ime
7,8-didehidro-4,5α-epoksi-14-cinamoil-3-metoksi-17-metilmorfinan-6-on
Klinički podaci
Identifikatori
CAS broj 751-01-9
ATC kod nije dodeljen
PubChem[1][2] 6438241
ChemSpider[3] 4942728
Hemijski podaci
Formula C27H25NO5 
Mol. masa 443,490 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

14-Cinamoiloksikodeinon je najpotentniji primer u seriji opijatnih analgetika. On je otkriven tokom 1960-tih i oko 100 puta je potentniji od morfina.[4] On je derivat hidroksikodeinona, koji sadrži 14-cinamatni estar.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Lien, E. J.; Tong, G. L.; Srulevitch, D. B.; Dias, C. (1978). "QSAR of Narcotic Analgetic Agents" (PDF). NIDA Research Monograph 1978 (22): 186–196. PMID 30907. 
  5. Buckett, W. R. (1965). "Some Pharmacological Studies With 14-Cinnamoyloxycodeinone". The Journal of Pharmacy and Pharmacology 17 (11): 759–760. PMID 4379812.