7-Spiroindaniloksimorfon

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7-Spiroindaniloksimorfon
(IUPAC) ime
(4aR-(4aα,7aα,8α,9cα))- 1',3',7,7a,8,9- Hexahydro- 3,7a-dihydroxy- 12-methylspiro (6H-8,9c- (iminoethano) phenanthro (4,5-bcd) furan- 6,2'- (2H)inden)- 5(4aH)- one
Klinički podaci
Identifikatori
CAS broj 150380-34-0
ATC kod  ?
PubChem[1][2] 5487084
ChemSpider[3] 8176808
Hemijski podaci
Formula C25H25NO4 
Mol. masa 403.470 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

7-Spiroindaniloksimorfon (SIOM) je lek koji se koristi u naučnim istraživanjima. On je selektivni δ-opioidni agonist.[4][5][6][7][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Portoghese PS, Moe ST, Takemori AE (1993). "A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists". Journal of medicinal chemistry 36 (17): 2572–4. PMID 8394935. 
  5. Fang X, Larson DL, Portoghese PS (1997). "7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands". Journal of medicinal chemistry 40 (19): 3064–70. PMID 9301669. doi:10.1021/jm970283e. 
  6. Ohkawa S, Digiacomo B, Larson DL, Takemori AE, Portoghese PS (1997). "7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors". Journal of medicinal chemistry 40 (11): 1720–5. PMID 9171881. doi:10.1021/jm9700880. 
  7. Kshirsagar TA, Fang X, Portoghese PS (1998). "14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors". Journal of medicinal chemistry 41 (14): 2657–60. PMID 9651172. doi:10.1021/jm980209b. 
  8. Shenderovich MD, Liao S, Qian X, Hruby VJ (2000). "A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands". Biopolymers 53 (7): 565–80. PMID 10766952. doi:10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5. 

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