ICI-204,448

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ICI-204,448
(IUPAC) ime
2-(3-[1-([2-(3,4-dichlorophenyl)acetyl]-methylamino)-2-pyrrolidin-1-ylethyl]phenoxy)acetic acid
Klinički podaci
Identifikatori
CAS broj 121264-04-8
ATC kod ?
PubChem[1][2] 3683
Hemijski podaci
Formula C23H26Cl2N2O4 
Mol. masa 465.368 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

ICI-204,448 je lek koji deluje kao potentan i periferno selektivan κ-opioidni agonist, sa mogućom primenom u lečenju srčanog udara kao i antisvrabnih efekata.[3][4] On se koristi u istraživanjima za uočavanje razlike između centralnih od periferno posredovanih efekata kapa opioidnog receptora.[5][6]

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Peart JN, Gross ER, Gross GJ (March 2004). „Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction”. Journal of Cardiovascular Pharmacology 43 (3): 410–5. PMID 15076225. 
  4. Inan S, Cowan A (October 2004). „Kappa opioid agonists suppress chloroquine-induced scratching in mice”. European Journal of Pharmacology 502 (3): 233–7. DOI:10.1016/j.ejphar.2004.09.010. PMID 15476749. 
  5. Schindler CW, Graczyk Z, Gilman JP, Negus SS, Bergman J, Mello NK, Goldberg SR (December 2007). „Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys”. European Journal of Pharmacology 576 (1-3): 107–13. DOI:10.1016/j.ejphar.2007.07.053. PMID 17707792. 
  6. Shannon HE, Eberle EL, Mitch CH, McKinzie DL, Statnick MA (December 2007). „Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats”. Neuropharmacology 53 (8): 930–41. DOI:10.1016/j.neuropharm.2007.09.002. PMID 17959202. 

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