N-Fenetil-14-etoksimetopon

N-Fenetil-14-etoksimetopon
(IUPAC) ime
	(5α)-14-etoksi- 3-hidroksi- 5-metil- 17-(2-feniletil)- 4,5-epoksimorfinan- 6-on
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	11049533
Hemijski podaci
Formula	C27H31NO4
Mol. masa	433,538 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C27H31NO4/c1-3-31-27-13-11-22(30)25(2)26(27)14-16-28(15-12-18-7-5-4-6-8-18)21(27)17-19-9-10-20(29)24(32-25)23(19)26/h4-10,21,29H,3,11-17H2,1-2H3 ; Key: YNNFSTLAUJEYHI-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

N-Fenetil-14-etoksimetopon je lek koji je derivat metopona. On je potentan analgetik, oko 60 puta jači nego morfin i proizvodi konstipaciju u znatno manjoj meri.^[3]

N-fenetil-14-etoksimetopon deluje kao agonist na μ- i δ-opioidnim receptorima, sa Ki od 0.16nM na μ i 3.14nM na δ.^[4]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Ananthan, S (2006). „Opioid ligands with mixed mi/delta opioid receptor interactions: an emerging approach to novel analgesics”. The AAPS journal 8 (1): E118–25. DOI:10.1208/aapsj080114. PMC 2751430. PMID 16584118.
↑ Lattanzi, R; Spetea, M; Schüllner, F; Rief, SB; Krassnig, R; Negri, L; Schmidhammer, H (2005). „Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities”. Journal of medicinal chemistry 48 (9): 3372–8. DOI:10.1021/jm040894o. PMID 15857143.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Ananthan, S (2006). „Opioid ligands with mixed mi/delta opioid receptor interactions: an emerging approach to novel analgesics”. The AAPS journal 8 (1): E118–25. DOI:10.1208/aapsj080114. PMC 2751430. PMID 16584118.

[4] Lattanzi, R; Spetea, M; Schüllner, F; Rief, SB; Krassnig, R; Negri, L; Schmidhammer, H (2005). „Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities”. Journal of medicinal chemistry 48 (9): 3372–8. DOI:10.1021/jm040894o. PMID 15857143.

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N-Fenetil-14-etoksimetopon

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