DPI-3290

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DPI-3290
(IUPAC) ime
(+)-3-((αR)-α-((2S,5R)-4-Alil-2,5-dimetil-1-piperazinil)-3-hidroksibenzil)-N-(3-fluorofenil)-N-metilbenzamid
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 5242141
Hemijski podaci
Formula C30H34FN3O2 
Mol. masa 487.607 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

DPI-3290 je lek koji se koristi u naučnim istraživanjima. On je potentan analgetik,[3] koji zaziva neznatnu respiratornu depresiju.[4]

DPI-3290 deluje kao agonist μ- i δ-opioidnog receptora, sa IC50 vrednošću od 6.2 nM na μ i 1.0 nM na δ.[5]

Literatura[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gengo, PJ; Pettit, HO; O'Neill, SJ; Wei, K; McNutt, R; Bishop, MJ; Chang, KJ (2003). "DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. I. A mixed opioid agonist with potent antinociceptive activity". The Journal of pharmacology and experimental therapeutics 307 (3): 1221–6. PMID 14534368. doi:10.1124/jpet.103.054361. 
  4. Gengo, PJ; Pettit, HO; O'Neill, SJ; Su, YF; McNutt, R; Chang, KJ (2003). "DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function". The Journal of pharmacology and experimental therapeutics 307 (3): 1227–33. PMID 14534367. doi:10.1124/jpet.103.054429. 
  5. Ananthan S. Opioid ligands with mixed mi/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS Journal. 2006 Mar 10;8(1):E118-25. DOI 10.1208/aapsj080114 PMID 16584118

Spoljašnje veze[uredi - уреди | uredi izvor]


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