Nalmekson

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Nalmekson
(IUPAC) ime
(5α)-3,14-dihidroksi-17-(3-metil-2-buten-1-il)-4,5-epoksimorfinan-6-on
Klinički podaci
Identifikatori
CAS broj 16676-26-9
16291-05-7 (HCl)
ATC kod nije dodeljen
PubChem[1][2] 5360516
ChemSpider[3] 4514525
Hemijski podaci
Formula C21H25NO4 
Mol. masa 355,428 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Nalmekson (INN; EN-1620A, UM-592, nalmekson hidrohlorid) je semisintetički, mešoviti opioidni agonist-antagonist sa analgetičkim i narkotičnim svojstvima.[4][5][6][7] U kliničkim ispitivanjima utvrđeno je da ima analgetičku efikastnost sličnu morfinu, mada sa nekoliko puta umanjenom potentnošću.[8] Osim toga, nuspojave nalmeksona su pospanost i znojenje, slično morfinu, mada u znatnom većem stepenu i učestalošću.[8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. str. 1395. ISBN 978-0-412-46630-4. http://books.google.com/books?id=A0THacd46ZsC&pg=PA1395. pristupljeno 11. 5. 2012.. 
  5. Casy, Alan F.; Parfitt, Robert T. (1986). Opioid Analgesics: Chemistry and Receptors. Springer. str. 55. ISBN 978-0-306-42130-3. http://books.google.com/books?id=KTWoPZdOwQAC&pg=PA55. pristupljeno 11. 5. 2012.. 
  6. Loew GH, Berkowitz DS (January 1978). "Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics". Journal of Medicinal Chemistry 21 (1): 101–6. PMID 73588. 
  7. Forrest WH, Shroff PF, Mahler DL (1972). "Analgesic and other effects of nalmexone in man". Clinical Pharmacology and Therapeutics 13 (4): 520–5. PMID 4557582. 
  8. 8,0 8,1 National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969*). Bulletin, problems of drug dependence. National Academies. str. 5873. NAP:10503. http://books.google.com/books?id=BUcrAAAAYAAJ&pg=PA5873. pristupljeno 11. 5. 2012.. 

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