BRL-52537

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BRL-52537
(IUPAC) ime
2-(3,4-diclorofenil)-1-[(2S)-2-(pirolidin-1-ilmetil)piperidin-1-il]etanon
Klinički podaci
Identifikatori
CAS broj 130497-33-5
ATC kod nije dodeljen
PubChem[1][2] 6603740
Hemijski podaci
Formula C18H24Cl2N2O 
Mol. masa 355.301 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

BRL-52537 je lek koji deluje kao potentan i visoko selektivan κ-opioidni agonist.[3] On je pokazao neuroprotektivno dejstvo u studijama na životinjama,[4][5] i koristi se za istraživanje potencijalnih tretmana za moždani i srčani udar, kao i za neka uopštenija istraživanja mozga.[6][7][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD (January 1991). "(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics". Journal of Medicinal Chemistry 34 (1): 397–403. PMID 1846921. 
  4. Goyagi T, Toung TJ, Kirsch JR, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A (June 2003). "Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats". Stroke; a Journal of Cerebral Circulation 34 (6): 1533–8. PMID 12738895. doi:10.1161/01.STR.0000072512.30658.E7. 
  5. Zhang Z, Chen TY, Kirsch JR, Toung TJ, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A (December 2003). "Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats". Anesthesia and Analgesia 97 (6): 1776–83. PMID 14633559. 
  6. Chen TY, Goyagi T, Toung TJ, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A (May 2004). "Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats". Stroke; a Journal of Cerebral Circulation 35 (5): 1180–5. PMID 15031456. doi:10.1161/01.STR.0000125011.93188.c6. 
  7. Peart JN, Gross ER, Gross GJ (March 2004). "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction". Journal of Cardiovascular Pharmacology 43 (3): 410–5. PMID 15076225. 
  8. Britt JP, McGehee DS (February 2008). "Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens". The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 28 (7): 1672–81. PMID 18272687. doi:10.1523/JNEUROSCI.4275-07.2008. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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