N-Acetilglukozamin

N-Acetilglukozamin
	2-(Acetylamino)-2-deoxy-D-glucose
Drugi nazivi	N-Acetyl-D-Glucosamine; GlcNAc; NAG
Identifikacija
CAS registarski broj	7512-17-6
PubChem	24139
ChemSpider	22563
UNII	V956696549
ChEBI	28009
ChEMBL	CHEMBL447878
Jmol-3D slike	Slika 1
SMILES
	O=C(N[C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@H]1O)CO)C
InChI
	InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1 ; Kod: OVRNDRQMDRJTHS-FMDGEEDCSA-N
Svojstva
Molekulska formula	C8H15NO6
Molarna masa	221.21
Tačka topljenja	211
Opasnost
S-oznake	S24/25
Srodna jedinjenja
Srodna Monosaharidi	N-Acetilgalaktozamin
Srodna jedinjenja	Glukozamin; Glukoza
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

N-Acetilglukozamin (N-acetil-D-glukozamin, GlcNAc, NAG) je monosaharidni derivat glukoze. On je amid između glukozamina i sirćetne kiseline. Njegova molekulska formula je C₈H₁₅N O₆, i molarna masa je 221.21 g/mol. On je značajan u više bioloških sistema.^[5]

On je deo biopolimera bakterijskog ćelijskog zida, izgraćenog od alternirajućih jedinica GlcNAc i N-acetilmuraminske kiseline (MurNAc), umrežene sa oligopeptidima na laktatnim ostacima MurNAc. Ova slojasta struktura se naziva peptidoglikan.

GlcNAc je monomerna jedinica polimera hitina, koji formira spoljašnji pokrivač insekata i rakova.

Polimerizovan sa glukuronskom kiselinom on formira hialuronan.

Medicinska upotreba

Smatra se da može da nađe primenu u lečenju autoimunih bolesti.^[6]

Povezano

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell. New York: Garlard Science. ISBN 0-8153-3218-1.
↑ „Sugar supplement may treat immune disease - health - 07 June 2007 - New Scientist”. Pristupljeno 8. 6. 2007.

Vanjske veze

N-Acetilglukozamin Arhivirano 2011-09-07 na Wayback Machine-u
Multipla Skleroza Arhivirano 2012-02-13 na Wayback Machine-u

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[AlbertsMolecularBiology4th-5] Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell. New York: Garlard Science. ISBN 0-8153-3218-1.

[6] „Sugar supplement may treat immune disease - health - 07 June 2007 - New Scientist”. Pristupljeno 8. 6. 2007.

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