NNC 63-0532

NNC 63-0532
(IUPAC) ime
	methyl [8-(1-naphthylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl)acetate
Klinički podaci
Identifikatori
CAS broj	250685-44-0
ATC kod	?
PubChem	9803475
Hemijski podaci
Formula	C27H29N3O3
Mol. masa	443.536 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3 ; Key: AQMPIDSGLFVVPL-UHFFFAOYSA-N
Sinonimi	NNC 63-0532
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

NNC 63-0532 je nociceptinski lek koji se koristi u naučnim istraživanjima. On deluje kao potentan i selektivan agonist nociceptinskog receptora (ORL-1).^[3]^[4] Funkcija ovog receptor je još uvek nedovoljno istražena. Smatra se da učestvuje mnoštvu poremećaja kao što je bol, zavisnost od droga, razvoj tolerancije na opioidne lekove, i psihološkim poremećajima poput anksioznosti i depresija. Istraživanje funkcije ovog receptora je jedan od važnih fokusa današnjeg farmaceutiskog razvoja, i selektivni ligandi kao što je NNC 63-0532 su esencijalni u tom radu.^[5]

Literatura[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Thomsen C, Hohlweg R. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. British Journal of Pharmacology. 2000 Nov;131(5):903-8. PMID 11053209
↑ Guerrini R, Carra' G, Calo' G, Trapella C, Marzola E, Rizzi D, Regoli D, Salvadori S. Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity. Journal of Peptide Research. 2004 Jun;63(6):477-84. PMID 15175020
↑ Chiou LC, Liao YY, Fan PC, Kuo PH, Wang CH, Riemer C, Prinssen EP. Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications. Current Drug Targets. 2007 Jan;8(1):117-35. PMID 17266536

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Thomsen C, Hohlweg R. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. British Journal of Pharmacology. 2000 Nov;131(5):903-8. PMID 11053209

[4] Guerrini R, Carra' G, Calo' G, Trapella C, Marzola E, Rizzi D, Regoli D, Salvadori S. Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity. Journal of Peptide Research. 2004 Jun;63(6):477-84. PMID 15175020

[5] Chiou LC, Liao YY, Fan PC, Kuo PH, Wang CH, Riemer C, Prinssen EP. Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications. Current Drug Targets. 2007 Jan;8(1):117-35. PMID 17266536

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NNC 63-0532

Literatura[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

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